Association between trauma exposure and respiratory disease-A Mendelian randomization study
BackgroundTrauma is a well-known risk factor for many disease, but the effect of trauma on respiratory disease is unclarified. In the present study, we aimed to evaluate the association between trauma and respiratory disease.MethodUsing both United Kingdom biobank and Finnish biobank genome-wide ass...
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| Format: | Article |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1001223/full |
| _version_ | 1798037204673495040 |
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| author | Yuchao Ma Changjiang Meng Liang Weng Liang Weng Liang Weng Liang Weng Liang Weng |
| author_facet | Yuchao Ma Changjiang Meng Liang Weng Liang Weng Liang Weng Liang Weng Liang Weng |
| author_sort | Yuchao Ma |
| collection | DOAJ |
| description | BackgroundTrauma is a well-known risk factor for many disease, but the effect of trauma on respiratory disease is unclarified. In the present study, we aimed to evaluate the association between trauma and respiratory disease.MethodUsing both United Kingdom biobank and Finnish biobank genome-wide association study data (GWAS), we performed a two-sample Mendelian randomization (MR) analysis to evaluate the relationship between trauma and respiratory disease. We used four methods including inverse-variance weighted (IVW), weighted median, Maximum likelihood, and MR-Egger in this MR analysis. The IVW MR was selected as the main method. We also performed multivariable Mendelian randomization (MVMR) to simultaneously assess the independent impact of trauma exposure on respiratory disease.ResultsIn the main two-sample MR analysis, trauma exposure was significantly associated with increased risk of respiratory disease (OR 1.15, 95%CI: 1.05-1.25). Besides, there was no heterogeneity and horizontal pleiotropy observed in the sensitivity analysis. After adjusting for pack years of smoking and body mass index (BMI), trauma exposure retained its association with respiratory disease (OR, 1.13, 95%CI, 1.04-1.23 adjusted by pack years of smoking; and OR, 1.11, 95%CI, 1.04-1.18 adjusted by BMI).ConclusionOur study discovered the association between trauma exposure and the increased risk of respiratory disease, suggesting the prevention and treatment with trauma to reduce the risk of respiratory disease. |
| first_indexed | 2024-04-11T21:23:25Z |
| format | Article |
| id | doaj.art-d05348b1b8b3417ebab7ea4a7c9b1c14 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T21:23:25Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-d05348b1b8b3417ebab7ea4a7c9b1c142022-12-22T04:02:31ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-09-011310.3389/fendo.2022.10012231001223Association between trauma exposure and respiratory disease-A Mendelian randomization studyYuchao Ma0Changjiang Meng1Liang Weng2Liang Weng3Liang Weng4Liang Weng5Liang Weng6Department of Cardiothoracic Surgery, Third Xiangya Hospital, Central South University, Changsha, ChinaClinical Research Center, Third Xiangya Hospital, Central South University, Changsha, ChinaXiangya Cancer Center, Xiangya Hospital, Central South University, Changsha, ChinaKey Laboratory of Molecular Radiation Oncology Hunan Province, Xiangya Hospital, Central South University, Changsha, ChinaHunan International Science and Technology Collaboration Base of Precision Medicine for Cancer, Xiangya Hospital, Central South University, Changsha, ChinaInstitute of Gerontological Cancer Research, National Clinical Research Center for Gerontology, Changsha, ChinaXiangya Lung Cancer Center, Xiangya Hospital, Central South University, Changsha, ChinaBackgroundTrauma is a well-known risk factor for many disease, but the effect of trauma on respiratory disease is unclarified. In the present study, we aimed to evaluate the association between trauma and respiratory disease.MethodUsing both United Kingdom biobank and Finnish biobank genome-wide association study data (GWAS), we performed a two-sample Mendelian randomization (MR) analysis to evaluate the relationship between trauma and respiratory disease. We used four methods including inverse-variance weighted (IVW), weighted median, Maximum likelihood, and MR-Egger in this MR analysis. The IVW MR was selected as the main method. We also performed multivariable Mendelian randomization (MVMR) to simultaneously assess the independent impact of trauma exposure on respiratory disease.ResultsIn the main two-sample MR analysis, trauma exposure was significantly associated with increased risk of respiratory disease (OR 1.15, 95%CI: 1.05-1.25). Besides, there was no heterogeneity and horizontal pleiotropy observed in the sensitivity analysis. After adjusting for pack years of smoking and body mass index (BMI), trauma exposure retained its association with respiratory disease (OR, 1.13, 95%CI, 1.04-1.23 adjusted by pack years of smoking; and OR, 1.11, 95%CI, 1.04-1.18 adjusted by BMI).ConclusionOur study discovered the association between trauma exposure and the increased risk of respiratory disease, suggesting the prevention and treatment with trauma to reduce the risk of respiratory disease.https://www.frontiersin.org/articles/10.3389/fendo.2022.1001223/fulltraumarespiratory diseaseMendelian randomizationMVMRinstrumental variable (IV) |
| spellingShingle | Yuchao Ma Changjiang Meng Liang Weng Liang Weng Liang Weng Liang Weng Liang Weng Association between trauma exposure and respiratory disease-A Mendelian randomization study Frontiers in Endocrinology trauma respiratory disease Mendelian randomization MVMR instrumental variable (IV) |
| title | Association between trauma exposure and respiratory disease-A Mendelian randomization study |
| title_full | Association between trauma exposure and respiratory disease-A Mendelian randomization study |
| title_fullStr | Association between trauma exposure and respiratory disease-A Mendelian randomization study |
| title_full_unstemmed | Association between trauma exposure and respiratory disease-A Mendelian randomization study |
| title_short | Association between trauma exposure and respiratory disease-A Mendelian randomization study |
| title_sort | association between trauma exposure and respiratory disease a mendelian randomization study |
| topic | trauma respiratory disease Mendelian randomization MVMR instrumental variable (IV) |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1001223/full |
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