Regulation of Mitochondrial Respiration by Hydrogen Sulfide
Hydrogen sulfide (H<sub>2</sub>S), the third gasotransmitter, has positive roles in animals and plants. Mitochondria are the source and the target of H<sub>2</sub>S and the regulatory hub in metabolism, stress, and disease. Mitochondrial bioenergetics is a vital process that...
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| Format: | Article |
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MDPI AG
2023-08-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/8/1644 |
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| author | Dandan Huang Guangqin Jing Shuhua Zhu |
| author_facet | Dandan Huang Guangqin Jing Shuhua Zhu |
| author_sort | Dandan Huang |
| collection | DOAJ |
| description | Hydrogen sulfide (H<sub>2</sub>S), the third gasotransmitter, has positive roles in animals and plants. Mitochondria are the source and the target of H<sub>2</sub>S and the regulatory hub in metabolism, stress, and disease. Mitochondrial bioenergetics is a vital process that produces ATP and provides energy to support the physiological and biochemical processes. H<sub>2</sub>S regulates mitochondrial bioenergetic functions and mitochondrial oxidative phosphorylation. The article summarizes the recent knowledge of the chemical and biological characteristics, the mitochondrial biosynthesis of H<sub>2</sub>S, and the regulatory effects of H<sub>2</sub>S on the tricarboxylic acid cycle and the mitochondrial respiratory chain complexes. The roles of H<sub>2</sub>S on the tricarboxylic acid cycle and mitochondrial respiratory complexes in mammals have been widely studied. The biological function of H<sub>2</sub>S is now a hot topic in plants. Mitochondria are also vital organelles regulating plant processes. The regulation of H<sub>2</sub>S in plant mitochondrial functions is gaining more and more attention. This paper mainly summarizes the current knowledge on the regulatory effects of H<sub>2</sub>S on the tricarboxylic acid cycle (TCA) and the mitochondrial respiratory chain. A study of the roles of H<sub>2</sub>S in mitochondrial respiration in plants to elucidate the botanical function of H<sub>2</sub>S in plants would be highly desirable. |
| first_indexed | 2024-03-11T00:10:56Z |
| format | Article |
| id | doaj.art-d0538faaca0e4c32afc0c2bf1dfa9b70 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T00:10:56Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-d0538faaca0e4c32afc0c2bf1dfa9b702023-11-19T00:03:13ZengMDPI AGAntioxidants2076-39212023-08-01128164410.3390/antiox12081644Regulation of Mitochondrial Respiration by Hydrogen SulfideDandan Huang0Guangqin Jing1Shuhua Zhu2College of Chemistry and Material Science, Shandong Agricultural University, Taian 271018, ChinaCollege of Chemistry and Material Science, Shandong Agricultural University, Taian 271018, ChinaCollege of Chemistry and Material Science, Shandong Agricultural University, Taian 271018, ChinaHydrogen sulfide (H<sub>2</sub>S), the third gasotransmitter, has positive roles in animals and plants. Mitochondria are the source and the target of H<sub>2</sub>S and the regulatory hub in metabolism, stress, and disease. Mitochondrial bioenergetics is a vital process that produces ATP and provides energy to support the physiological and biochemical processes. H<sub>2</sub>S regulates mitochondrial bioenergetic functions and mitochondrial oxidative phosphorylation. The article summarizes the recent knowledge of the chemical and biological characteristics, the mitochondrial biosynthesis of H<sub>2</sub>S, and the regulatory effects of H<sub>2</sub>S on the tricarboxylic acid cycle and the mitochondrial respiratory chain complexes. The roles of H<sub>2</sub>S on the tricarboxylic acid cycle and mitochondrial respiratory complexes in mammals have been widely studied. The biological function of H<sub>2</sub>S is now a hot topic in plants. Mitochondria are also vital organelles regulating plant processes. The regulation of H<sub>2</sub>S in plant mitochondrial functions is gaining more and more attention. This paper mainly summarizes the current knowledge on the regulatory effects of H<sub>2</sub>S on the tricarboxylic acid cycle (TCA) and the mitochondrial respiratory chain. A study of the roles of H<sub>2</sub>S in mitochondrial respiration in plants to elucidate the botanical function of H<sub>2</sub>S in plants would be highly desirable.https://www.mdpi.com/2076-3921/12/8/1644hydrogen sulfidemitochondriaoxidative phosphorylationtricarboxylic acid cyclemitochondrial respiratory complex |
| spellingShingle | Dandan Huang Guangqin Jing Shuhua Zhu Regulation of Mitochondrial Respiration by Hydrogen Sulfide Antioxidants hydrogen sulfide mitochondria oxidative phosphorylation tricarboxylic acid cycle mitochondrial respiratory complex |
| title | Regulation of Mitochondrial Respiration by Hydrogen Sulfide |
| title_full | Regulation of Mitochondrial Respiration by Hydrogen Sulfide |
| title_fullStr | Regulation of Mitochondrial Respiration by Hydrogen Sulfide |
| title_full_unstemmed | Regulation of Mitochondrial Respiration by Hydrogen Sulfide |
| title_short | Regulation of Mitochondrial Respiration by Hydrogen Sulfide |
| title_sort | regulation of mitochondrial respiration by hydrogen sulfide |
| topic | hydrogen sulfide mitochondria oxidative phosphorylation tricarboxylic acid cycle mitochondrial respiratory complex |
| url | https://www.mdpi.com/2076-3921/12/8/1644 |
| work_keys_str_mv | AT dandanhuang regulationofmitochondrialrespirationbyhydrogensulfide AT guangqinjing regulationofmitochondrialrespirationbyhydrogensulfide AT shuhuazhu regulationofmitochondrialrespirationbyhydrogensulfide |