New Nitrogen Compounds Coupled to Phenolic Units with Antioxidant and Antifungal Activities: Synthesis and Structure–Activity Relationship

New Nitrogen Compounds Coupled to Phenolic Units with Antioxidant and Antifungal Activities: Synthesis and Structure–Activity Relationship

A selection of 1-amino-2-arylidenamine-1,2-(dicyano)ethenes 3 was synthesized and cyclized to 2-aryl-4,5-dicyano-1H-imidazoles 4 upon reflux in ethyl acetate/acetonitrile, in the presence of manganese dioxide. These compounds were tested for their antioxidant capacity by cyclic voltammetry, 2,2-diph...

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Bibliographic Details
Main Authors: Ana Bettencourt, Marián Castro, João Silva, Francisco Fernandes, Olga Coutinho, M. João Sousa, M. Fernanda Proença, Filipe Areias
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Molecules
Subjects:
Imidazoles
phenolic compounds
antifungal activity
MIC
antioxidant capacity
structure-activity relationship
Online Access:http://www.mdpi.com/1420-3049/23/10/2530

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