Role of heterotrimeric G proteins in platelet activation and clot formation in platelets treated with integrin αIIbβ3 inhibitor

Role of heterotrimeric G proteins in platelet activation and clot formation in platelets treated with integrin αIIbβ3 inhibitor

Mechanisms of platelet activation are triggered by thrombin, adenosine diphosphate (ADP), epinephrine, thromboxane A2, and other soluble agonists which induce signaling via heterotrimeric Gαq, Gαi, and Gα12/13 proteins. We have undertaken a study addressing the contribution of these G proteins to pl...

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Bibliographic Details
Main Authors: Ivan Budnik, Boris Shenkman, Hagit Hauschner, Isaac Zilinsky, Naphtali Savion
Format: Article
Language:English
Published: Taylor & Francis Group 2018-04-01
Series:Platelets
Subjects:
clot formation
g proteins
platelet activation
rotation thromboelastometry
Online Access:http://dx.doi.org/10.1080/09537104.2017.1295136

Internet

http://dx.doi.org/10.1080/09537104.2017.1295136

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