Radiation-Induced Fibrosis in Patients with Head and Neck Cancer: A Review of Pathogenesis and Clinical Outcomes

Radiotherapy-related fibrosis remains one of the most challenging treatment related side effects encountered by patients with head and neck cancer. Several established and ongoing novel therapies have been studied with paucity of data in how to best treat these patients. This review aims to provide...

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Main Authors: Paul Ramia, Larry Bodgi, Dima Mahmoud, Mohammad A Mohammad, Bassem Youssef, Neil Kopek, Humaid Al-Shamsi, Mona Dagher, Ibrahim Abu-Gheida
Format: Article
Language:English
Published: SAGE Publishing 2022-01-01
Series:Clinical Medicine Insights: Oncology
Online Access:https://doi.org/10.1177/11795549211036898
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author Paul Ramia
Larry Bodgi
Dima Mahmoud
Mohammad A Mohammad
Bassem Youssef
Neil Kopek
Humaid Al-Shamsi
Mona Dagher
Ibrahim Abu-Gheida
author_facet Paul Ramia
Larry Bodgi
Dima Mahmoud
Mohammad A Mohammad
Bassem Youssef
Neil Kopek
Humaid Al-Shamsi
Mona Dagher
Ibrahim Abu-Gheida
author_sort Paul Ramia
collection DOAJ
description Radiotherapy-related fibrosis remains one of the most challenging treatment related side effects encountered by patients with head and neck cancer. Several established and ongoing novel therapies have been studied with paucity of data in how to best treat these patients. This review aims to provide researchers and health care providers with a comprehensive review on the presentation, etiology, and therapeutic options for this serious condition.
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spelling doaj.art-d0570b4d399e473688e8a245d67ba50a2022-12-22T02:38:25ZengSAGE PublishingClinical Medicine Insights: Oncology1179-55492022-01-011610.1177/11795549211036898Radiation-Induced Fibrosis in Patients with Head and Neck Cancer: A Review of Pathogenesis and Clinical OutcomesPaul Ramia0Larry Bodgi1Dima Mahmoud2Mohammad A Mohammad3Bassem Youssef4Neil Kopek5Humaid Al-Shamsi6Mona Dagher7Ibrahim Abu-Gheida8McGill University Health Centre, Montreal, QC, CanadaDepartment of Radiation Oncology, American University of Beirut Medical Center, Beirut, LebanonDepartment of Radiation Oncology, American University of Beirut Medical Center, Beirut, LebanonDepartment of Radiation Oncology, American University of Beirut Medical Center, Beirut, LebanonDepartment of Radiation Oncology, American University of Beirut Medical Center, Beirut, LebanonMcGill University Health Centre, Montreal, QC, CanadaUniversity of Sharjah, Sharjah, United Arab EmiratesDepartment of Radiation Oncology, American University of Beirut Medical Center, Beirut, LebanonUnited Arab Emirates University, Al Ain, United Arab EmiratesRadiotherapy-related fibrosis remains one of the most challenging treatment related side effects encountered by patients with head and neck cancer. Several established and ongoing novel therapies have been studied with paucity of data in how to best treat these patients. This review aims to provide researchers and health care providers with a comprehensive review on the presentation, etiology, and therapeutic options for this serious condition.https://doi.org/10.1177/11795549211036898
spellingShingle Paul Ramia
Larry Bodgi
Dima Mahmoud
Mohammad A Mohammad
Bassem Youssef
Neil Kopek
Humaid Al-Shamsi
Mona Dagher
Ibrahim Abu-Gheida
Radiation-Induced Fibrosis in Patients with Head and Neck Cancer: A Review of Pathogenesis and Clinical Outcomes
Clinical Medicine Insights: Oncology
title Radiation-Induced Fibrosis in Patients with Head and Neck Cancer: A Review of Pathogenesis and Clinical Outcomes
title_full Radiation-Induced Fibrosis in Patients with Head and Neck Cancer: A Review of Pathogenesis and Clinical Outcomes
title_fullStr Radiation-Induced Fibrosis in Patients with Head and Neck Cancer: A Review of Pathogenesis and Clinical Outcomes
title_full_unstemmed Radiation-Induced Fibrosis in Patients with Head and Neck Cancer: A Review of Pathogenesis and Clinical Outcomes
title_short Radiation-Induced Fibrosis in Patients with Head and Neck Cancer: A Review of Pathogenesis and Clinical Outcomes
title_sort radiation induced fibrosis in patients with head and neck cancer a review of pathogenesis and clinical outcomes
url https://doi.org/10.1177/11795549211036898
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