Pinpointing Neural Correlates of Attachment in Poly-Drug Use: A Diffusion Tensor Imaging Study
An increasing amount of evidence indicates the significance of attachment in the etiology of poly-drug use disorder (PUD). The aim of this study was to investigate associations between PUD and adult attachment in particular, with a focus on white matter (WM) fiber tract integrity. For this purpose,...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2020.00596/full |
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| author | J. Fuchshuber J. Fuchshuber H. F. Unterrainer H. F. Unterrainer H. F. Unterrainer M. Hiebler-Ragger M. Hiebler-Ragger K. Koschutnig I. Papousek E. M. Weiss A. Fink |
| author_facet | J. Fuchshuber J. Fuchshuber H. F. Unterrainer H. F. Unterrainer H. F. Unterrainer M. Hiebler-Ragger M. Hiebler-Ragger K. Koschutnig I. Papousek E. M. Weiss A. Fink |
| author_sort | J. Fuchshuber |
| collection | DOAJ |
| description | An increasing amount of evidence indicates the significance of attachment in the etiology of poly-drug use disorder (PUD). The aim of this study was to investigate associations between PUD and adult attachment in particular, with a focus on white matter (WM) fiber tract integrity. For this purpose, we selected several regions-of-interest based on previous findings which were examined for their role in PUD and estimated whole-brain associations between adult attachment and WM integrity. A total sample of 144 right-handed males were investigated (Age: M = 27; SD = 4.66). This included a group of patients diagnosed with PUD (n = 70) and a group of healthy controls (HC; n = 74). The Adult Attachment Scales (AAS) was applied to assess attachment attitudes in participants. Diffusion Tensor Imaging was used to investigate differences in WM integrity. The findings suggest substantially less attachment security in PUD patients compared to HC. Furthermore, PUD patients exhibited reduced integrity in WM fiber tracts, most pronounced in the bilateral corticospinal tract, the fronto-occipital fasciculus, and the right inferior longitudinal fasciculus. However, these results were not controlled for comorbid depressiveness. With regard to associations between adult attachment and WM integrity, the results for PUD patients indicate a negative relationship between “Comfort with Closeness” and the structural integrity of a cluster comprising parts of the right anterior thalamic radiation, the inferior fronto-occipital fasciculus and the uncinate fasciculus. Despite being limited by the cross-sectional design of this study, the results emphasize the significance of attachment in PUD etiology, both at a behavioral and a neurological level. Largely in line with previous research, the findings revealed tentative links between adult attachment and WM fiber tracts related to cognitive and affective functions in PUD patients. |
| first_indexed | 2024-12-11T10:09:30Z |
| format | Article |
| id | doaj.art-d059b9a5e89143f0bdb3328c57f04667 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-11T10:09:30Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-d059b9a5e89143f0bdb3328c57f046672022-12-22T01:11:47ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2020-06-011410.3389/fnins.2020.00596506617Pinpointing Neural Correlates of Attachment in Poly-Drug Use: A Diffusion Tensor Imaging StudyJ. Fuchshuber0J. Fuchshuber1H. F. Unterrainer2H. F. Unterrainer3H. F. Unterrainer4M. Hiebler-Ragger5M. Hiebler-Ragger6K. Koschutnig7I. Papousek8E. M. Weiss9A. Fink10Center for Integrative Addiction Research (CIAR), Grüner Kreis Society, Vienna, AustriaUniversity Clinic for Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, AustriaCenter for Integrative Addiction Research (CIAR), Grüner Kreis Society, Vienna, AustriaUniversity Clinic for Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, AustriaDepartment of Religious Studies, University of Vienna, Vienna, AustriaCenter for Integrative Addiction Research (CIAR), Grüner Kreis Society, Vienna, AustriaUniversity Clinic for Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, AustriaInstitute of Psychology, University of Graz, Graz, AustriaInstitute of Psychology, University of Graz, Graz, AustriaInstitute of Psychology, University of Innsbruck, Innsbruck, AustriaInstitute of Psychology, University of Graz, Graz, AustriaAn increasing amount of evidence indicates the significance of attachment in the etiology of poly-drug use disorder (PUD). The aim of this study was to investigate associations between PUD and adult attachment in particular, with a focus on white matter (WM) fiber tract integrity. For this purpose, we selected several regions-of-interest based on previous findings which were examined for their role in PUD and estimated whole-brain associations between adult attachment and WM integrity. A total sample of 144 right-handed males were investigated (Age: M = 27; SD = 4.66). This included a group of patients diagnosed with PUD (n = 70) and a group of healthy controls (HC; n = 74). The Adult Attachment Scales (AAS) was applied to assess attachment attitudes in participants. Diffusion Tensor Imaging was used to investigate differences in WM integrity. The findings suggest substantially less attachment security in PUD patients compared to HC. Furthermore, PUD patients exhibited reduced integrity in WM fiber tracts, most pronounced in the bilateral corticospinal tract, the fronto-occipital fasciculus, and the right inferior longitudinal fasciculus. However, these results were not controlled for comorbid depressiveness. With regard to associations between adult attachment and WM integrity, the results for PUD patients indicate a negative relationship between “Comfort with Closeness” and the structural integrity of a cluster comprising parts of the right anterior thalamic radiation, the inferior fronto-occipital fasciculus and the uncinate fasciculus. Despite being limited by the cross-sectional design of this study, the results emphasize the significance of attachment in PUD etiology, both at a behavioral and a neurological level. Largely in line with previous research, the findings revealed tentative links between adult attachment and WM fiber tracts related to cognitive and affective functions in PUD patients.https://www.frontiersin.org/article/10.3389/fnins.2020.00596/fullattachmentDiffusion Tensor Imagingpoly-drug useregions of interestwhite matter |
| spellingShingle | J. Fuchshuber J. Fuchshuber H. F. Unterrainer H. F. Unterrainer H. F. Unterrainer M. Hiebler-Ragger M. Hiebler-Ragger K. Koschutnig I. Papousek E. M. Weiss A. Fink Pinpointing Neural Correlates of Attachment in Poly-Drug Use: A Diffusion Tensor Imaging Study Frontiers in Neuroscience attachment Diffusion Tensor Imaging poly-drug use regions of interest white matter |
| title | Pinpointing Neural Correlates of Attachment in Poly-Drug Use: A Diffusion Tensor Imaging Study |
| title_full | Pinpointing Neural Correlates of Attachment in Poly-Drug Use: A Diffusion Tensor Imaging Study |
| title_fullStr | Pinpointing Neural Correlates of Attachment in Poly-Drug Use: A Diffusion Tensor Imaging Study |
| title_full_unstemmed | Pinpointing Neural Correlates of Attachment in Poly-Drug Use: A Diffusion Tensor Imaging Study |
| title_short | Pinpointing Neural Correlates of Attachment in Poly-Drug Use: A Diffusion Tensor Imaging Study |
| title_sort | pinpointing neural correlates of attachment in poly drug use a diffusion tensor imaging study |
| topic | attachment Diffusion Tensor Imaging poly-drug use regions of interest white matter |
| url | https://www.frontiersin.org/article/10.3389/fnins.2020.00596/full |
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