Three Constituents of <i>Moringa oleifera</i> Seeds Regulate Expression of Th17-Relevant Cytokines and Ameliorate TPA-Induced Psoriasis-Like Skin Lesions in Mice
As a folk medicine, <i>Moringa oleifera</i> L. is used effectively to treat inflammatory conditions and skin diseases. However, its mechanism of action is not well understood, limiting its medical use. We isolated and identified three compounds, namely niazirin, marumoside A and sitoster...
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MDPI AG
2018-12-01
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| Series: | Molecules |
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| author | Nuan Ma Qin Tang Wan-Ting Wu Xin-An Huang Qin Xu Guang-Li Rong Song Chen Jian-Ping Song |
| author_facet | Nuan Ma Qin Tang Wan-Ting Wu Xin-An Huang Qin Xu Guang-Li Rong Song Chen Jian-Ping Song |
| author_sort | Nuan Ma |
| collection | DOAJ |
| description | As a folk medicine, <i>Moringa oleifera</i> L. is used effectively to treat inflammatory conditions and skin diseases. However, its mechanism of action is not well understood, limiting its medical use. We isolated and identified three compounds, namely niazirin, marumoside A and sitosterol-<i>3</i>-<i>O</i>-<i>β</i>-<span style="font-variant: small-caps;">d</span>-glucoside, from the seeds of <i>Moringa oleifera</i>, and studied their effects on the expression of Th17-relevant cytokines (IL-12/IL-23 p40, IL-17A, IL-22 and IL-23 p19) using lipopolysaccharide-stimulated THP-1 cells. Additionally, as Th17 plays a critical role in the pathogenesis of psoriasis, we used a <i>12</i>-<i>O</i>-tetradecanoylphorbol-<i>13</i>-acetate (TPA)-induced psoriasis-like skin lesion mouse model to study their potential therapeutic application in vivo. The compounds suppressed the expression of IL-12/IL-23 p40, IL-17A, IL-22 and IL-23 p19 in vitro, and in vivo they ameliorated psoriasis-like skin lesions, decreased IL-17A mRNA expression, and increased the expression of keratinocyte differentiation markers. To our knowledge, this is the first report regarding the mechanism and therapeutic application of <i>Moringa oleifera</i> seeds to treat psoriasis-like lesions in vivo. |
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| spelling | doaj.art-d05a6e04511b4c4a8a115c925dfce8c52022-12-22T00:08:55ZengMDPI AGMolecules1420-30492018-12-012312325610.3390/molecules23123256molecules23123256Three Constituents of <i>Moringa oleifera</i> Seeds Regulate Expression of Th17-Relevant Cytokines and Ameliorate TPA-Induced Psoriasis-Like Skin Lesions in MiceNuan Ma0Qin Tang1Wan-Ting Wu2Xin-An Huang3Qin Xu4Guang-Li Rong5Song Chen6Jian-Ping Song7Institute of Tropical Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, ChinaInstitute of Tropical Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, ChinaInstitute of Tropical Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, ChinaInstitute of Tropical Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, ChinaInstitute of Tropical Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, ChinaInstitute of Tropical Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, ChinaInstitute of Tropical Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, ChinaInstitute of Tropical Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, ChinaAs a folk medicine, <i>Moringa oleifera</i> L. is used effectively to treat inflammatory conditions and skin diseases. However, its mechanism of action is not well understood, limiting its medical use. We isolated and identified three compounds, namely niazirin, marumoside A and sitosterol-<i>3</i>-<i>O</i>-<i>β</i>-<span style="font-variant: small-caps;">d</span>-glucoside, from the seeds of <i>Moringa oleifera</i>, and studied their effects on the expression of Th17-relevant cytokines (IL-12/IL-23 p40, IL-17A, IL-22 and IL-23 p19) using lipopolysaccharide-stimulated THP-1 cells. Additionally, as Th17 plays a critical role in the pathogenesis of psoriasis, we used a <i>12</i>-<i>O</i>-tetradecanoylphorbol-<i>13</i>-acetate (TPA)-induced psoriasis-like skin lesion mouse model to study their potential therapeutic application in vivo. The compounds suppressed the expression of IL-12/IL-23 p40, IL-17A, IL-22 and IL-23 p19 in vitro, and in vivo they ameliorated psoriasis-like skin lesions, decreased IL-17A mRNA expression, and increased the expression of keratinocyte differentiation markers. To our knowledge, this is the first report regarding the mechanism and therapeutic application of <i>Moringa oleifera</i> seeds to treat psoriasis-like lesions in vivo.https://www.mdpi.com/1420-3049/23/12/3256<i>Moringa oleifera</i>niazirinmarumoside Asitosterol-<i>3</i>-<i>O</i>-<i>β</i>-<span style="font-variant: small-caps">d</span>-glucopyranosideTh17psoriasis |
| spellingShingle | Nuan Ma Qin Tang Wan-Ting Wu Xin-An Huang Qin Xu Guang-Li Rong Song Chen Jian-Ping Song Three Constituents of <i>Moringa oleifera</i> Seeds Regulate Expression of Th17-Relevant Cytokines and Ameliorate TPA-Induced Psoriasis-Like Skin Lesions in Mice Molecules <i>Moringa oleifera</i> niazirin marumoside A sitosterol-<i>3</i>-<i>O</i>-<i>β</i>-<span style="font-variant: small-caps">d</span>-glucopyranoside Th17 psoriasis |
| title | Three Constituents of <i>Moringa oleifera</i> Seeds Regulate Expression of Th17-Relevant Cytokines and Ameliorate TPA-Induced Psoriasis-Like Skin Lesions in Mice |
| title_full | Three Constituents of <i>Moringa oleifera</i> Seeds Regulate Expression of Th17-Relevant Cytokines and Ameliorate TPA-Induced Psoriasis-Like Skin Lesions in Mice |
| title_fullStr | Three Constituents of <i>Moringa oleifera</i> Seeds Regulate Expression of Th17-Relevant Cytokines and Ameliorate TPA-Induced Psoriasis-Like Skin Lesions in Mice |
| title_full_unstemmed | Three Constituents of <i>Moringa oleifera</i> Seeds Regulate Expression of Th17-Relevant Cytokines and Ameliorate TPA-Induced Psoriasis-Like Skin Lesions in Mice |
| title_short | Three Constituents of <i>Moringa oleifera</i> Seeds Regulate Expression of Th17-Relevant Cytokines and Ameliorate TPA-Induced Psoriasis-Like Skin Lesions in Mice |
| title_sort | three constituents of i moringa oleifera i seeds regulate expression of th17 relevant cytokines and ameliorate tpa induced psoriasis like skin lesions in mice |
| topic | <i>Moringa oleifera</i> niazirin marumoside A sitosterol-<i>3</i>-<i>O</i>-<i>β</i>-<span style="font-variant: small-caps">d</span>-glucopyranoside Th17 psoriasis |
| url | https://www.mdpi.com/1420-3049/23/12/3256 |
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