Preparation and Properties of Double-Crosslinked Hydroxyapatite Composite Hydrogels
Natural polymer hydrogels have good mechanical properties and biocompatibility. This study designed hydroxyapatite-enhanced photo-oxidized double-crosslinked hydrogels. Hyaluronic acid (HA) and gelatin (Gel) were modified with methacrylate anhydride. The catechin group was further introduced into th...
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| Format: | Article |
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MDPI AG
2022-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/17/9962 |
| _version_ | 1797495102310973440 |
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| author | Benbo Zhao Mingda Zhao Liming Li Shixiong Sun Heping Yu Yuan Cheng Yuedi Yang Yujiang Fan Yong Sun |
| author_facet | Benbo Zhao Mingda Zhao Liming Li Shixiong Sun Heping Yu Yuan Cheng Yuedi Yang Yujiang Fan Yong Sun |
| author_sort | Benbo Zhao |
| collection | DOAJ |
| description | Natural polymer hydrogels have good mechanical properties and biocompatibility. This study designed hydroxyapatite-enhanced photo-oxidized double-crosslinked hydrogels. Hyaluronic acid (HA) and gelatin (Gel) were modified with methacrylate anhydride. The catechin group was further introduced into the HA chain inspired by the adhesion chemistry of marine mussels. Hence, the double-crosslinked hydrogel (HG) was formed by the photo-crosslinking of double bonds and the oxidative-crosslinking of catechins. Moreover, hydroxyapatite was introduced into HG to form hydroxyapatite-enhanced hydrogels (HGH). The results indicate that, with an increase in crosslinking network density, the stiffness of hydrogels became higher; these hydrogels have more of a compact pore structure, their anti-degradation property is improved, and swelling property is reduced. The introduction of hydroxyapatite greatly improved the mechanical properties of hydrogels, but there is no change in the stability and crosslinking network structure of hydrogels. These inorganic phase-enhanced hydrogels were expected to be applied to tissue engineering scaffolds. |
| first_indexed | 2024-03-10T01:43:38Z |
| format | Article |
| id | doaj.art-d05ce9f04f74406190a50e6bbff626e5 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:43:38Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d05ce9f04f74406190a50e6bbff626e52023-11-23T13:20:18ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-09-012317996210.3390/ijms23179962Preparation and Properties of Double-Crosslinked Hydroxyapatite Composite HydrogelsBenbo Zhao0Mingda Zhao1Liming Li2Shixiong Sun3Heping Yu4Yuan Cheng5Yuedi Yang6Yujiang Fan7Yong Sun8School of Chemical Engineering and Technology, North University of China, Taiyuan 030051, ChinaNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, ChinaSchool of Chemical Engineering and Technology, North University of China, Taiyuan 030051, ChinaSchool of Chemical Engineering and Technology, North University of China, Taiyuan 030051, ChinaGuangdong Provincial Key Laboratory of Natural Rubber Processing, Agricultural Products Processing Research Institute, Chinese Academy of Tropical Sciences, Zhanjiang 524001, ChinaSchool of Chemical Engineering and Technology, North University of China, Taiyuan 030051, ChinaNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, ChinaNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, ChinaNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, ChinaNatural polymer hydrogels have good mechanical properties and biocompatibility. This study designed hydroxyapatite-enhanced photo-oxidized double-crosslinked hydrogels. Hyaluronic acid (HA) and gelatin (Gel) were modified with methacrylate anhydride. The catechin group was further introduced into the HA chain inspired by the adhesion chemistry of marine mussels. Hence, the double-crosslinked hydrogel (HG) was formed by the photo-crosslinking of double bonds and the oxidative-crosslinking of catechins. Moreover, hydroxyapatite was introduced into HG to form hydroxyapatite-enhanced hydrogels (HGH). The results indicate that, with an increase in crosslinking network density, the stiffness of hydrogels became higher; these hydrogels have more of a compact pore structure, their anti-degradation property is improved, and swelling property is reduced. The introduction of hydroxyapatite greatly improved the mechanical properties of hydrogels, but there is no change in the stability and crosslinking network structure of hydrogels. These inorganic phase-enhanced hydrogels were expected to be applied to tissue engineering scaffolds.https://www.mdpi.com/1422-0067/23/17/9962hyaluronic acidgelatindopaminedouble crosslinkedhydroxyapatite-enhanced hydrogel |
| spellingShingle | Benbo Zhao Mingda Zhao Liming Li Shixiong Sun Heping Yu Yuan Cheng Yuedi Yang Yujiang Fan Yong Sun Preparation and Properties of Double-Crosslinked Hydroxyapatite Composite Hydrogels International Journal of Molecular Sciences hyaluronic acid gelatin dopamine double crosslinked hydroxyapatite-enhanced hydrogel |
| title | Preparation and Properties of Double-Crosslinked Hydroxyapatite Composite Hydrogels |
| title_full | Preparation and Properties of Double-Crosslinked Hydroxyapatite Composite Hydrogels |
| title_fullStr | Preparation and Properties of Double-Crosslinked Hydroxyapatite Composite Hydrogels |
| title_full_unstemmed | Preparation and Properties of Double-Crosslinked Hydroxyapatite Composite Hydrogels |
| title_short | Preparation and Properties of Double-Crosslinked Hydroxyapatite Composite Hydrogels |
| title_sort | preparation and properties of double crosslinked hydroxyapatite composite hydrogels |
| topic | hyaluronic acid gelatin dopamine double crosslinked hydroxyapatite-enhanced hydrogel |
| url | https://www.mdpi.com/1422-0067/23/17/9962 |
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