Screening Biomarkers for Systemic Lupus Erythematosus Based on Machine Learning and Exploring Their Expression Correlations With the Ratios of Various Immune Cells

Screening Biomarkers for Systemic Lupus Erythematosus Based on Machine Learning and Exploring Their Expression Correlations With the Ratios of Various Immune Cells

BackgroundSystemic lupus erythematosus (SLE) is an autoimmune illness caused by a malfunctioning immunomodulatory system. China has the second highest prevalence of SLE in the world, from 0.03% to 0.07%. SLE is diagnosed using a combination of immunological markers, clinical symptoms, and even invas...

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Bibliographic Details
Main Authors: Yafang Zhong, Wei Zhang, Xiaoping Hong, Zhipeng Zeng, Yumei Chen, Shengyou Liao, Wanxia Cai, Yong Xu, Gang Wang, Dongzhou Liu, Donge Tang, Yong Dai
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
machine learning
diagnostic biomarker
systemic lupus erythematosus
immune cell disturbance
CIBERSORT
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.873787/full

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