Recent insights into the biology of pancreatic cancer
Pancreatic cancer (PDAC) is one of the deadliest types of human cancers, owing to late stage at presentation and pervasive therapeutic resistance. The extensive tumour heterogeneity, as well as substantial crosstalk between the neoplastic epithelium and components within the microenvironment are the...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-03-01
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| Series: | EBioMedicine |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S235239642030030X |
| _version_ | 1818926108000649216 |
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| author | Wantong Yao Anirban Maitra Haoqiang Ying |
| author_facet | Wantong Yao Anirban Maitra Haoqiang Ying |
| author_sort | Wantong Yao |
| collection | DOAJ |
| description | Pancreatic cancer (PDAC) is one of the deadliest types of human cancers, owing to late stage at presentation and pervasive therapeutic resistance. The extensive tumour heterogeneity, as well as substantial crosstalk between the neoplastic epithelium and components within the microenvironment are the defining features of PDAC biology that dictate the dismal natural history. Recent advances in genomic and molecular profiling have informed on the genetic makeup and evolutionary patterns of tumour progression, leading to treatment breakthroughs in minor subsets of patients with specific tumour mutational profiles. The nature and function of tumour heterogeneity, including stromal heterogeneity, in PDAC development and therapeutic resistance, are increasingly being elucidated. Deep insight has been gained regarding the metabolic and immunological deregulation, which further sheds light on the complex biology and the observed treatment recalcitrance. Here we will summarize these recent achievements and offer our perspective on the path forward. Keywords: Pancreatic cancer, Genetics, Ttumour heterogeneity, Cancer metabolism, Immune, Evasion, Immunotherapy |
| first_indexed | 2024-12-20T02:51:52Z |
| format | Article |
| id | doaj.art-d060416207424f1bbbc673ba0c93fbc8 |
| institution | Directory Open Access Journal |
| issn | 2352-3964 |
| language | English |
| last_indexed | 2024-12-20T02:51:52Z |
| publishDate | 2020-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EBioMedicine |
| spelling | doaj.art-d060416207424f1bbbc673ba0c93fbc82022-12-21T19:56:00ZengElsevierEBioMedicine2352-39642020-03-0153Recent insights into the biology of pancreatic cancerWantong Yao0Anirban Maitra1Haoqiang Ying2Department of Translational Molecular Pathology, Houston, TX, USADepartment of Translational Molecular Pathology, Houston, TX, USA; Sheikh Ahmed Center for Pancreatic Cancer Research, Houston, TX, USADepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Corresponding author.Pancreatic cancer (PDAC) is one of the deadliest types of human cancers, owing to late stage at presentation and pervasive therapeutic resistance. The extensive tumour heterogeneity, as well as substantial crosstalk between the neoplastic epithelium and components within the microenvironment are the defining features of PDAC biology that dictate the dismal natural history. Recent advances in genomic and molecular profiling have informed on the genetic makeup and evolutionary patterns of tumour progression, leading to treatment breakthroughs in minor subsets of patients with specific tumour mutational profiles. The nature and function of tumour heterogeneity, including stromal heterogeneity, in PDAC development and therapeutic resistance, are increasingly being elucidated. Deep insight has been gained regarding the metabolic and immunological deregulation, which further sheds light on the complex biology and the observed treatment recalcitrance. Here we will summarize these recent achievements and offer our perspective on the path forward. Keywords: Pancreatic cancer, Genetics, Ttumour heterogeneity, Cancer metabolism, Immune, Evasion, Immunotherapyhttp://www.sciencedirect.com/science/article/pii/S235239642030030X |
| spellingShingle | Wantong Yao Anirban Maitra Haoqiang Ying Recent insights into the biology of pancreatic cancer EBioMedicine |
| title | Recent insights into the biology of pancreatic cancer |
| title_full | Recent insights into the biology of pancreatic cancer |
| title_fullStr | Recent insights into the biology of pancreatic cancer |
| title_full_unstemmed | Recent insights into the biology of pancreatic cancer |
| title_short | Recent insights into the biology of pancreatic cancer |
| title_sort | recent insights into the biology of pancreatic cancer |
| url | http://www.sciencedirect.com/science/article/pii/S235239642030030X |
| work_keys_str_mv | AT wantongyao recentinsightsintothebiologyofpancreaticcancer AT anirbanmaitra recentinsightsintothebiologyofpancreaticcancer AT haoqiangying recentinsightsintothebiologyofpancreaticcancer |