Polysaccharide Layer-by-Layer Coating for Polyimide-Based Neural Interfaces
Implantable flexible neural interfaces (IfNIs) are capable of directly modulating signals of the central and peripheral nervous system by stimulating or recording the action potential. Despite outstanding results in acute experiments on animals and humans, their long-term biocompatibility is hampere...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Micromachines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-666X/13/5/692 |
| _version_ | 1827667806504615936 |
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| author | Eugenio Redolfi Riva Angela D’Alessio Silvestro Micera |
| author_facet | Eugenio Redolfi Riva Angela D’Alessio Silvestro Micera |
| author_sort | Eugenio Redolfi Riva |
| collection | DOAJ |
| description | Implantable flexible neural interfaces (IfNIs) are capable of directly modulating signals of the central and peripheral nervous system by stimulating or recording the action potential. Despite outstanding results in acute experiments on animals and humans, their long-term biocompatibility is hampered by the effects of foreign body reactions that worsen electrical performance and cause tissue damage. We report on the fabrication of a polysaccharide nanostructured thin film as a coating of polyimide (PI)-based IfNIs. The layer-by-layer technique was used to coat the PI surface due to its versatility and ease of manufacturing. Two different LbL deposition techniques were tested and compared: dip coating and spin coating. Morphological and physiochemical characterization showed the presence of a very smooth and nanostructured thin film coating on the PI surface that remarkably enhanced surface hydrophilicity with respect to the bare PI surface for both the deposition techniques. However, spin coating offered more control over the fabrication properties, with the possibility to tune the coating’s physiochemical and morphological properties. Overall, the proposed coating strategies allowed the deposition of a biocompatible nanostructured film onto the PI surface and could represent a valid tool to enhance long-term IfNI biocompatibility by improving tissue/electrode integration. |
| first_indexed | 2024-03-10T03:24:27Z |
| format | Article |
| id | doaj.art-d0619b48e0c34ca9b8142ec0327b63f1 |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-10T03:24:27Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-d0619b48e0c34ca9b8142ec0327b63f12023-11-23T12:11:40ZengMDPI AGMicromachines2072-666X2022-04-0113569210.3390/mi13050692Polysaccharide Layer-by-Layer Coating for Polyimide-Based Neural InterfacesEugenio Redolfi Riva0Angela D’Alessio1Silvestro Micera2The BioRobotics Institute, Department of Excellence in Robotics and AI, Scuola Superiore Sant’Anna, 56127 Pisa, ItalyThe BioRobotics Institute, Department of Excellence in Robotics and AI, Scuola Superiore Sant’Anna, 56127 Pisa, ItalyThe BioRobotics Institute, Department of Excellence in Robotics and AI, Scuola Superiore Sant’Anna, 56127 Pisa, ItalyImplantable flexible neural interfaces (IfNIs) are capable of directly modulating signals of the central and peripheral nervous system by stimulating or recording the action potential. Despite outstanding results in acute experiments on animals and humans, their long-term biocompatibility is hampered by the effects of foreign body reactions that worsen electrical performance and cause tissue damage. We report on the fabrication of a polysaccharide nanostructured thin film as a coating of polyimide (PI)-based IfNIs. The layer-by-layer technique was used to coat the PI surface due to its versatility and ease of manufacturing. Two different LbL deposition techniques were tested and compared: dip coating and spin coating. Morphological and physiochemical characterization showed the presence of a very smooth and nanostructured thin film coating on the PI surface that remarkably enhanced surface hydrophilicity with respect to the bare PI surface for both the deposition techniques. However, spin coating offered more control over the fabrication properties, with the possibility to tune the coating’s physiochemical and morphological properties. Overall, the proposed coating strategies allowed the deposition of a biocompatible nanostructured film onto the PI surface and could represent a valid tool to enhance long-term IfNI biocompatibility by improving tissue/electrode integration.https://www.mdpi.com/2072-666X/13/5/692nanostructured coatinglayer-by-layerneural interfacelong-term biocompatibilitybioelectronic medicineelectrode–tissue interface |
| spellingShingle | Eugenio Redolfi Riva Angela D’Alessio Silvestro Micera Polysaccharide Layer-by-Layer Coating for Polyimide-Based Neural Interfaces Micromachines nanostructured coating layer-by-layer neural interface long-term biocompatibility bioelectronic medicine electrode–tissue interface |
| title | Polysaccharide Layer-by-Layer Coating for Polyimide-Based Neural Interfaces |
| title_full | Polysaccharide Layer-by-Layer Coating for Polyimide-Based Neural Interfaces |
| title_fullStr | Polysaccharide Layer-by-Layer Coating for Polyimide-Based Neural Interfaces |
| title_full_unstemmed | Polysaccharide Layer-by-Layer Coating for Polyimide-Based Neural Interfaces |
| title_short | Polysaccharide Layer-by-Layer Coating for Polyimide-Based Neural Interfaces |
| title_sort | polysaccharide layer by layer coating for polyimide based neural interfaces |
| topic | nanostructured coating layer-by-layer neural interface long-term biocompatibility bioelectronic medicine electrode–tissue interface |
| url | https://www.mdpi.com/2072-666X/13/5/692 |
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