Houttuynia cordata polysaccharide alleviates chronic vascular inflammation by suppressing calcium-sensing receptor in rats
The present study explored activities of orally administrated Houttuynia cordata polysaccharide (HCP) on vascular chronic inflammation which was established by a tail-vein injection of lipopolysaccharide (LPS) once weekly for 6 weeks in rats. Results showed that administration of HCP significantly a...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622002420 |
| _version_ | 1818180488442937344 |
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| author | Teng Li Ting Sang Ye-Hao Song Xun-Jiao Hu Qiong Wu Yu-Fei Yao Wen-Juan Li |
| author_facet | Teng Li Ting Sang Ye-Hao Song Xun-Jiao Hu Qiong Wu Yu-Fei Yao Wen-Juan Li |
| author_sort | Teng Li |
| collection | DOAJ |
| description | The present study explored activities of orally administrated Houttuynia cordata polysaccharide (HCP) on vascular chronic inflammation which was established by a tail-vein injection of lipopolysaccharide (LPS) once weekly for 6 weeks in rats. Results showed that administration of HCP significantly alleviated chronic inflammation by reducing white blood cell and monocyte counts, together with repairing histological impairment of vascular tissue. Furthermore, vascular protections of HCP were in association with decrease of MDA content, pro-inflammatory cytokines interleukin-1beta (IL-1β) and tumor necrosis factor-α (TNF-α), and enhancement of the activities of antioxidant enzyme superoxide dismutase, catalase, glutathione peroxidase activities. Moreover, HCP exhibited anti-inflammatory responses evidenced by reducing the expressions of Toll-like receptor 4 (TLR4) and NF-kB P65. Meanwhile, the combination of HCP and LPS reduced calcium concentration and CaSR mRNA expression in the vascular tissue. Collectively, these results indicated that HCP suppressed LPS-induced chronic vascular inflammation via calcium-sensing receptor and TLR4/NF-kB pathways in rats. |
| first_indexed | 2024-12-11T21:20:34Z |
| format | Article |
| id | doaj.art-d0628601947c4968bacc636e75da78c0 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-11T21:20:34Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-d0628601947c4968bacc636e75da78c02022-12-22T00:50:29ZengElsevierJournal of Functional Foods1756-46462022-08-0195105172Houttuynia cordata polysaccharide alleviates chronic vascular inflammation by suppressing calcium-sensing receptor in ratsTeng Li0Ting Sang1Ye-Hao Song2Xun-Jiao Hu3Qiong Wu4Yu-Fei Yao5Wen-Juan Li6State Key Laboratory of Food Science and Technology, Nanchang University, 235 Nanjing East Road, Nanchang 330047, ChinaThe Affiliated Stomatological Hospital of Nanchang University & The Key Laboratory of Oral Biomedicine, Nanchang 330006, ChinaState Key Laboratory of Food Science and Technology, Nanchang University, 235 Nanjing East Road, Nanchang 330047, ChinaCollege of Pharmacy, Nanchang University, Nanchang, 999 Xuefu Road, Nanchang 330031, ChinaThe Second Affiliated Hospital of Nanchang University, 1 Minde Road, Nanchang 330006, ChinaDepartment of Critical Care Medicine, The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China; Corresponding authors.State Key Laboratory of Food Science and Technology, Nanchang University, 235 Nanjing East Road, Nanchang 330047, China; Corresponding authors.The present study explored activities of orally administrated Houttuynia cordata polysaccharide (HCP) on vascular chronic inflammation which was established by a tail-vein injection of lipopolysaccharide (LPS) once weekly for 6 weeks in rats. Results showed that administration of HCP significantly alleviated chronic inflammation by reducing white blood cell and monocyte counts, together with repairing histological impairment of vascular tissue. Furthermore, vascular protections of HCP were in association with decrease of MDA content, pro-inflammatory cytokines interleukin-1beta (IL-1β) and tumor necrosis factor-α (TNF-α), and enhancement of the activities of antioxidant enzyme superoxide dismutase, catalase, glutathione peroxidase activities. Moreover, HCP exhibited anti-inflammatory responses evidenced by reducing the expressions of Toll-like receptor 4 (TLR4) and NF-kB P65. Meanwhile, the combination of HCP and LPS reduced calcium concentration and CaSR mRNA expression in the vascular tissue. Collectively, these results indicated that HCP suppressed LPS-induced chronic vascular inflammation via calcium-sensing receptor and TLR4/NF-kB pathways in rats.http://www.sciencedirect.com/science/article/pii/S1756464622002420Houttuynia cordata polysaccharideChronic inflammationBlood vesselOxidative stressCalcium sensitive receptor |
| spellingShingle | Teng Li Ting Sang Ye-Hao Song Xun-Jiao Hu Qiong Wu Yu-Fei Yao Wen-Juan Li Houttuynia cordata polysaccharide alleviates chronic vascular inflammation by suppressing calcium-sensing receptor in rats Journal of Functional Foods Houttuynia cordata polysaccharide Chronic inflammation Blood vessel Oxidative stress Calcium sensitive receptor |
| title | Houttuynia cordata polysaccharide alleviates chronic vascular inflammation by suppressing calcium-sensing receptor in rats |
| title_full | Houttuynia cordata polysaccharide alleviates chronic vascular inflammation by suppressing calcium-sensing receptor in rats |
| title_fullStr | Houttuynia cordata polysaccharide alleviates chronic vascular inflammation by suppressing calcium-sensing receptor in rats |
| title_full_unstemmed | Houttuynia cordata polysaccharide alleviates chronic vascular inflammation by suppressing calcium-sensing receptor in rats |
| title_short | Houttuynia cordata polysaccharide alleviates chronic vascular inflammation by suppressing calcium-sensing receptor in rats |
| title_sort | houttuynia cordata polysaccharide alleviates chronic vascular inflammation by suppressing calcium sensing receptor in rats |
| topic | Houttuynia cordata polysaccharide Chronic inflammation Blood vessel Oxidative stress Calcium sensitive receptor |
| url | http://www.sciencedirect.com/science/article/pii/S1756464622002420 |
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