The brain mechanism of awakening dysfunction in children with primary nocturnal enuresis based on PVT-NAc neural pathway: a resting-state fMRI study
Abstract Primary nocturnal enuresis (PNE) affects children’s physical and mental health with a high rate. However, its neural mechanism is still unclear. Studies have found that the paraventricular thalamus (PVT) is among the key brain regions implicated with awakening regulation and its control of...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-96519-w |
| _version_ | 1818851596370444288 |
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| author | Kaihua Jiang Peng Xue Yue Xu Yang Yi Jie Zhu Li Ding Aibin Zheng |
| author_facet | Kaihua Jiang Peng Xue Yue Xu Yang Yi Jie Zhu Li Ding Aibin Zheng |
| author_sort | Kaihua Jiang |
| collection | DOAJ |
| description | Abstract Primary nocturnal enuresis (PNE) affects children’s physical and mental health with a high rate. However, its neural mechanism is still unclear. Studies have found that the paraventricular thalamus (PVT) is among the key brain regions implicated with awakening regulation and its control of the transition between sleep and wakening is dependent on signaling through the PVT-nucleus accumbens (NAc) pathway. So this study analyzed the function of brain regions and their connectivity of PVT and NAc. A total of twenty-six PNE and typically developing (TD) children were involved in the study and the methods of amplitude of low frequency fluctuation (ALFF), degree centrality (DC) and functional connectivity (FC) based on resting-state functional magnetic resonance imaging (rs-fMRI) were used to analyze the brain functions. Results showed that there was no statistical significant difference in ALFF and DC between PNE and TD children in bilateral PVT and NAc. And there was statistical significant difference of the comparison of the FC of left PVT (lPVT) and left NAc (lNAc) between PNE and TD children. Meanwhile, there was negative correlation between awakening score and the FC of rPVT and lNAc, and no obvious correlation between awakening score and the FC of lPVT and lNAc in PNE children. Meanwhile, there was both negative correlation between awakening score and the FC of lPVT, rPTV and lNAc in TD children. Therefore, the FC between rPVT and lNAc was more reliable in assessing the degree of awakening ability in PNE children. This finding could help establish the evaluation index of PNE. |
| first_indexed | 2024-12-19T07:07:32Z |
| format | Article |
| id | doaj.art-d0628d02060541ee881e5e9d0618d429 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T07:07:32Z |
| publishDate | 2021-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-d0628d02060541ee881e5e9d0618d4292022-12-21T20:31:15ZengNature PortfolioScientific Reports2045-23222021-08-011111710.1038/s41598-021-96519-wThe brain mechanism of awakening dysfunction in children with primary nocturnal enuresis based on PVT-NAc neural pathway: a resting-state fMRI studyKaihua Jiang0Peng Xue1Yue Xu2Yang Yi3Jie Zhu4Li Ding5Aibin Zheng6Department of Pediatrics, Changzhou Children’s Hospital of Nantong UniversityDepartment of Pediatrics, Changzhou Children’s Hospital of Nantong UniversityDepartment of Pediatrics, Changzhou Children’s Hospital of Nantong UniversityDepartment of Pediatrics, Changzhou Children’s Hospital of Nantong UniversityDepartment of Pediatrics, Changzhou Children’s Hospital of Nantong UniversityDepartment of Pediatrics, Changzhou Children’s Hospital of Nantong UniversityDepartment of Pediatrics, Changzhou Children’s Hospital of Nantong UniversityAbstract Primary nocturnal enuresis (PNE) affects children’s physical and mental health with a high rate. However, its neural mechanism is still unclear. Studies have found that the paraventricular thalamus (PVT) is among the key brain regions implicated with awakening regulation and its control of the transition between sleep and wakening is dependent on signaling through the PVT-nucleus accumbens (NAc) pathway. So this study analyzed the function of brain regions and their connectivity of PVT and NAc. A total of twenty-six PNE and typically developing (TD) children were involved in the study and the methods of amplitude of low frequency fluctuation (ALFF), degree centrality (DC) and functional connectivity (FC) based on resting-state functional magnetic resonance imaging (rs-fMRI) were used to analyze the brain functions. Results showed that there was no statistical significant difference in ALFF and DC between PNE and TD children in bilateral PVT and NAc. And there was statistical significant difference of the comparison of the FC of left PVT (lPVT) and left NAc (lNAc) between PNE and TD children. Meanwhile, there was negative correlation between awakening score and the FC of rPVT and lNAc, and no obvious correlation between awakening score and the FC of lPVT and lNAc in PNE children. Meanwhile, there was both negative correlation between awakening score and the FC of lPVT, rPTV and lNAc in TD children. Therefore, the FC between rPVT and lNAc was more reliable in assessing the degree of awakening ability in PNE children. This finding could help establish the evaluation index of PNE.https://doi.org/10.1038/s41598-021-96519-w |
| spellingShingle | Kaihua Jiang Peng Xue Yue Xu Yang Yi Jie Zhu Li Ding Aibin Zheng The brain mechanism of awakening dysfunction in children with primary nocturnal enuresis based on PVT-NAc neural pathway: a resting-state fMRI study Scientific Reports |
| title | The brain mechanism of awakening dysfunction in children with primary nocturnal enuresis based on PVT-NAc neural pathway: a resting-state fMRI study |
| title_full | The brain mechanism of awakening dysfunction in children with primary nocturnal enuresis based on PVT-NAc neural pathway: a resting-state fMRI study |
| title_fullStr | The brain mechanism of awakening dysfunction in children with primary nocturnal enuresis based on PVT-NAc neural pathway: a resting-state fMRI study |
| title_full_unstemmed | The brain mechanism of awakening dysfunction in children with primary nocturnal enuresis based on PVT-NAc neural pathway: a resting-state fMRI study |
| title_short | The brain mechanism of awakening dysfunction in children with primary nocturnal enuresis based on PVT-NAc neural pathway: a resting-state fMRI study |
| title_sort | brain mechanism of awakening dysfunction in children with primary nocturnal enuresis based on pvt nac neural pathway a resting state fmri study |
| url | https://doi.org/10.1038/s41598-021-96519-w |
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