Salvaging hope: Is increasing NAD+ a key to treating mitochondrial myopathy?
Mitochondrial diseases can arise from mutations either in mitochondrial DNA or in nuclear DNA encoding mitochondrially destined proteins. Currently, there is no cure for these diseases although treatments to ameliorate a subset of the symptoms are being developed. In this issue of EMBO Molecular Med...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Springer Nature
2014-06-01
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| Series: | EMBO Molecular Medicine |
| Online Access: | https://doi.org/10.15252/emmm.201404179 |
| _version_ | 1797225444793122816 |
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| author | Robert N Lightowlers Zofia MA Chrzanowska‐Lightowlers |
| author_facet | Robert N Lightowlers Zofia MA Chrzanowska‐Lightowlers |
| author_sort | Robert N Lightowlers |
| collection | DOAJ |
| description | Mitochondrial diseases can arise from mutations either in mitochondrial DNA or in nuclear DNA encoding mitochondrially destined proteins. Currently, there is no cure for these diseases although treatments to ameliorate a subset of the symptoms are being developed. In this issue of EMBO Molecular Medicine, Khan et al () use a mouse model to test the efficacy of a simple dietary supplement of nicotinamide riboside to treat and prevent mitochondrial myopathies. |
| first_indexed | 2024-03-13T03:11:16Z |
| format | Article |
| id | doaj.art-d0643ca2729248e09f1029479a3a756c |
| institution | Directory Open Access Journal |
| issn | 1757-4676 1757-4684 |
| language | English |
| last_indexed | 2024-04-24T14:09:07Z |
| publishDate | 2014-06-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj.art-d0643ca2729248e09f1029479a3a756c2024-04-03T09:38:21ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842014-06-016670570710.15252/emmm.201404179Salvaging hope: Is increasing NAD+ a key to treating mitochondrial myopathy?Robert N Lightowlers0Zofia MA Chrzanowska‐Lightowlers1Wellcome Trust Centre for Mitochondrial Research Institute for Cell and Molecular Biosciences Medical School Newcastle University Newcastle upon Tyne UKWellcome Trust Centre for Mitochondrial Research Institute for Cell and Molecular Biosciences Medical School Newcastle University Newcastle upon Tyne UKMitochondrial diseases can arise from mutations either in mitochondrial DNA or in nuclear DNA encoding mitochondrially destined proteins. Currently, there is no cure for these diseases although treatments to ameliorate a subset of the symptoms are being developed. In this issue of EMBO Molecular Medicine, Khan et al () use a mouse model to test the efficacy of a simple dietary supplement of nicotinamide riboside to treat and prevent mitochondrial myopathies.https://doi.org/10.15252/emmm.201404179 |
| spellingShingle | Robert N Lightowlers Zofia MA Chrzanowska‐Lightowlers Salvaging hope: Is increasing NAD+ a key to treating mitochondrial myopathy? EMBO Molecular Medicine |
| title | Salvaging hope: Is increasing NAD+ a key to treating mitochondrial myopathy? |
| title_full | Salvaging hope: Is increasing NAD+ a key to treating mitochondrial myopathy? |
| title_fullStr | Salvaging hope: Is increasing NAD+ a key to treating mitochondrial myopathy? |
| title_full_unstemmed | Salvaging hope: Is increasing NAD+ a key to treating mitochondrial myopathy? |
| title_short | Salvaging hope: Is increasing NAD+ a key to treating mitochondrial myopathy? |
| title_sort | salvaging hope is increasing nad a key to treating mitochondrial myopathy |
| url | https://doi.org/10.15252/emmm.201404179 |
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