The 3′ Pol II pausing at replication-dependent histone genes is regulated by Mediator through Cajal bodies’ association with histone locus bodies
Transcription termination is generally accompanied by the 3′-end processing of transcripts. Here the authors demonstrate a role for Mediator in transcript end site proximal pausing of replication-dependent histone genes.
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30632-w |
| _version_ | 1811253580430049280 |
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| author | Hidefumi Suzuki Ryota Abe Miho Shimada Tomonori Hirose Hiroko Hirose Keisuke Noguchi Yoko Ike Nanami Yasui Kazuki Furugori Yuki Yamaguchi Atsushi Toyoda Yutaka Suzuki Tatsuro Yamamoto Noriko Saitoh Shigeo Sato Chieri Tomomori-Sato Ronald C. Conaway Joan W. Conaway Hidehisa Takahashi |
| author_facet | Hidefumi Suzuki Ryota Abe Miho Shimada Tomonori Hirose Hiroko Hirose Keisuke Noguchi Yoko Ike Nanami Yasui Kazuki Furugori Yuki Yamaguchi Atsushi Toyoda Yutaka Suzuki Tatsuro Yamamoto Noriko Saitoh Shigeo Sato Chieri Tomomori-Sato Ronald C. Conaway Joan W. Conaway Hidehisa Takahashi |
| author_sort | Hidefumi Suzuki |
| collection | DOAJ |
| description | Transcription termination is generally accompanied by the 3′-end processing of transcripts. Here the authors demonstrate a role for Mediator in transcript end site proximal pausing of replication-dependent histone genes. |
| first_indexed | 2024-04-12T16:53:08Z |
| format | Article |
| id | doaj.art-d064a681bc454dca9b24cf1a9cc949a4 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T16:53:08Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d064a681bc454dca9b24cf1a9cc949a42022-12-22T03:24:19ZengNature PortfolioNature Communications2041-17232022-05-0113112410.1038/s41467-022-30632-wThe 3′ Pol II pausing at replication-dependent histone genes is regulated by Mediator through Cajal bodies’ association with histone locus bodiesHidefumi Suzuki0Ryota Abe1Miho Shimada2Tomonori Hirose3Hiroko Hirose4Keisuke Noguchi5Yoko Ike6Nanami Yasui7Kazuki Furugori8Yuki Yamaguchi9Atsushi Toyoda10Yutaka Suzuki11Tatsuro Yamamoto12Noriko Saitoh13Shigeo Sato14Chieri Tomomori-Sato15Ronald C. Conaway16Joan W. Conaway17Hidehisa Takahashi18Department of Molecular Biology, Yokohama City University Graduate School of Medical ScienceDepartment of Molecular Biology, Yokohama City University Graduate School of Medical ScienceDepartment of Molecular Biology, Yokohama City University Graduate School of Medical ScienceDepartment of Molecular Biology, Yokohama City University Graduate School of Medical ScienceDepartment of Molecular Biology, Yokohama City University Graduate School of Medical ScienceDepartment of Molecular Biology, Yokohama City University Graduate School of Medical ScienceDepartment of Molecular Biology, Yokohama City University Graduate School of Medical ScienceDepartment of Molecular Biology, Yokohama City University Graduate School of Medical ScienceDepartment of Molecular Biology, Yokohama City University Graduate School of Medical ScienceSchool of Life Science and Technology, Tokyo Institute of TechnologyComparative Genomics Laboratory, National Institute of GeneticsLaboratory of Systems Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of TokyoDivision of Cancer Biology, The Cancer Institute of JFCRDivision of Cancer Biology, The Cancer Institute of JFCRStowers Institute for Medical ResearchStowers Institute for Medical ResearchStowers Institute for Medical ResearchStowers Institute for Medical ResearchDepartment of Molecular Biology, Yokohama City University Graduate School of Medical ScienceTranscription termination is generally accompanied by the 3′-end processing of transcripts. Here the authors demonstrate a role for Mediator in transcript end site proximal pausing of replication-dependent histone genes.https://doi.org/10.1038/s41467-022-30632-w |
| spellingShingle | Hidefumi Suzuki Ryota Abe Miho Shimada Tomonori Hirose Hiroko Hirose Keisuke Noguchi Yoko Ike Nanami Yasui Kazuki Furugori Yuki Yamaguchi Atsushi Toyoda Yutaka Suzuki Tatsuro Yamamoto Noriko Saitoh Shigeo Sato Chieri Tomomori-Sato Ronald C. Conaway Joan W. Conaway Hidehisa Takahashi The 3′ Pol II pausing at replication-dependent histone genes is regulated by Mediator through Cajal bodies’ association with histone locus bodies Nature Communications |
| title | The 3′ Pol II pausing at replication-dependent histone genes is regulated by Mediator through Cajal bodies’ association with histone locus bodies |
| title_full | The 3′ Pol II pausing at replication-dependent histone genes is regulated by Mediator through Cajal bodies’ association with histone locus bodies |
| title_fullStr | The 3′ Pol II pausing at replication-dependent histone genes is regulated by Mediator through Cajal bodies’ association with histone locus bodies |
| title_full_unstemmed | The 3′ Pol II pausing at replication-dependent histone genes is regulated by Mediator through Cajal bodies’ association with histone locus bodies |
| title_short | The 3′ Pol II pausing at replication-dependent histone genes is regulated by Mediator through Cajal bodies’ association with histone locus bodies |
| title_sort | 3 pol ii pausing at replication dependent histone genes is regulated by mediator through cajal bodies association with histone locus bodies |
| url | https://doi.org/10.1038/s41467-022-30632-w |
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