Two cases report of a malignant germ cell tumour of ovary and a granulosa cell tumour:Interest of tumoral immunochemistry in the identification and management.
Abstract <br/>Objective: <br/>In this article, we present two case reports. The first case was a malignant germ cell tumor of the right ovary in a 23 year old female and a case of a bilateral undifferentiated granulosa cell tumor in a 71 year old female. The aim of these reports is to i...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014-05-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00097/full |
| _version_ | 1818298937500499968 |
|---|---|
| author | Jean eBouquet De Jolinière |
| author_facet | Jean eBouquet De Jolinière |
| author_sort | Jean eBouquet De Jolinière |
| collection | DOAJ |
| description | Abstract <br/>Objective: <br/>In this article, we present two case reports. The first case was a malignant germ cell tumor of the right ovary in a 23 year old female and a case of a bilateral undifferentiated granulosa cell tumor in a 71 year old female. The aim of these reports is to illustrate the interest of the immuno-histochemical analysis to define the correct diagnosis, to better classify these ovarian tumours and improve their management. <br/>Methods: <br/>This study we report two cases. The first case concern a 23 years old woman (A) with a mixed germ cell tumour of the right ovary (dysgerminoma (75%), yolk sac tumour (20%), and a mature teratoma (5%), and the second case (B) a bilateral non differentiated and necrotic granulosa cell tumour of both ovaries concerning a 71 year old patient. <br/>The staging system used was according to both classifications, the one of International Federation of Gynaecology and Obstetrics (FIGO) 1987 for ovarian cancer, and the one of TNM code 2009. <br/> Results: <br/>The immunostaining establish the malignancy and the immunochemistry contribute to confirm effectively the right diagnosis (Table 2 and 3). <br/>Conclusion: <br/>An immuno-histochemical analysis is mandatory for the choice of chemotherapy to obtain the better response of the disease and improve the survival prognosis. The efficiency of the chemotherapy authorizes a conservative surgery including a unilateral salpingo-oophorectomy preserving fertility (A). <br/>Concerning the non-dysgerminoma tumour (B), and after a surgical staging and debulking, chemotherapy was recommended. <br/>The type of tumour and its histological feature conditioned the choice of treatment. The benefit of the immunohistological analysis in this case allowed the right adjuvant treatment. <br/>Key words: germ cell tumours, dysgerminoma, teratoma, yolk sac, ovarian cell tumour, and immunohistochemistry. <br/> <br/> |
| first_indexed | 2024-12-13T04:43:16Z |
| format | Article |
| id | doaj.art-d064b167f35c43a7bf33b97a7a3796af |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-13T04:43:16Z |
| publishDate | 2014-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-d064b167f35c43a7bf33b97a7a3796af2022-12-21T23:59:15ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2014-05-01410.3389/fonc.2014.0009785776Two cases report of a malignant germ cell tumour of ovary and a granulosa cell tumour:Interest of tumoral immunochemistry in the identification and management.Jean eBouquet De Jolinière0HFR Hôpital cantonal Fribourg switzerlandAbstract <br/>Objective: <br/>In this article, we present two case reports. The first case was a malignant germ cell tumor of the right ovary in a 23 year old female and a case of a bilateral undifferentiated granulosa cell tumor in a 71 year old female. The aim of these reports is to illustrate the interest of the immuno-histochemical analysis to define the correct diagnosis, to better classify these ovarian tumours and improve their management. <br/>Methods: <br/>This study we report two cases. The first case concern a 23 years old woman (A) with a mixed germ cell tumour of the right ovary (dysgerminoma (75%), yolk sac tumour (20%), and a mature teratoma (5%), and the second case (B) a bilateral non differentiated and necrotic granulosa cell tumour of both ovaries concerning a 71 year old patient. <br/>The staging system used was according to both classifications, the one of International Federation of Gynaecology and Obstetrics (FIGO) 1987 for ovarian cancer, and the one of TNM code 2009. <br/> Results: <br/>The immunostaining establish the malignancy and the immunochemistry contribute to confirm effectively the right diagnosis (Table 2 and 3). <br/>Conclusion: <br/>An immuno-histochemical analysis is mandatory for the choice of chemotherapy to obtain the better response of the disease and improve the survival prognosis. The efficiency of the chemotherapy authorizes a conservative surgery including a unilateral salpingo-oophorectomy preserving fertility (A). <br/>Concerning the non-dysgerminoma tumour (B), and after a surgical staging and debulking, chemotherapy was recommended. <br/>The type of tumour and its histological feature conditioned the choice of treatment. The benefit of the immunohistological analysis in this case allowed the right adjuvant treatment. <br/>Key words: germ cell tumours, dysgerminoma, teratoma, yolk sac, ovarian cell tumour, and immunohistochemistry. <br/> <br/>http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00097/fullDysgerminomaTeratomaYolk Sacgerm cell tumoursovarian cell tumourand immunohistochemistry. |
| spellingShingle | Jean eBouquet De Jolinière Two cases report of a malignant germ cell tumour of ovary and a granulosa cell tumour:Interest of tumoral immunochemistry in the identification and management. Frontiers in Oncology Dysgerminoma Teratoma Yolk Sac germ cell tumours ovarian cell tumour and immunohistochemistry. |
| title | Two cases report of a malignant germ cell tumour of ovary and a granulosa cell tumour:Interest of tumoral immunochemistry in the identification and management. |
| title_full | Two cases report of a malignant germ cell tumour of ovary and a granulosa cell tumour:Interest of tumoral immunochemistry in the identification and management. |
| title_fullStr | Two cases report of a malignant germ cell tumour of ovary and a granulosa cell tumour:Interest of tumoral immunochemistry in the identification and management. |
| title_full_unstemmed | Two cases report of a malignant germ cell tumour of ovary and a granulosa cell tumour:Interest of tumoral immunochemistry in the identification and management. |
| title_short | Two cases report of a malignant germ cell tumour of ovary and a granulosa cell tumour:Interest of tumoral immunochemistry in the identification and management. |
| title_sort | two cases report of a malignant germ cell tumour of ovary and a granulosa cell tumour interest of tumoral immunochemistry in the identification and management |
| topic | Dysgerminoma Teratoma Yolk Sac germ cell tumours ovarian cell tumour and immunohistochemistry. |
| url | http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00097/full |
| work_keys_str_mv | AT jeanebouquetdejoliniere twocasesreportofamalignantgermcelltumourofovaryandagranulosacelltumourinterestoftumoralimmunochemistryintheidentificationandmanagement |