Adrenergic Signaling-Induced Ultrastructural Strengthening of Intercalated Discs via Plakoglobin Is Crucial for Positive Adhesiotropy in Murine Cardiomyocytes

Adrenergic Signaling-Induced Ultrastructural Strengthening of Intercalated Discs via Plakoglobin Is Crucial for Positive Adhesiotropy in Murine Cardiomyocytes

Intercalated discs (ICDs), which connect adjacent cardiomyocytes, are composed of desmosomes, adherens junctions (AJs) and gap junctions (GJs). Previous data demonstrated that adrenergic signaling enhances cardiac myocyte cohesion, referred to as positive adhesiotropy, via PKA-mediated phosphorylati...

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Bibliographic Details
Main Authors: Sunil Yeruva, Ellen Kempf, Desalegn Tadesse Egu, Heinrich Flaswinkel, Daniela Kugelmann, Jens Waschke
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Physiology
Subjects:
desmosome
arrhythmogenic cardiomyopathy
intercalated disc
intercellular adhesion
positive adhesiotropy
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00430/full

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