DNA Repair Gene Polymorphisms May Be Associated with Prognosis of Upper Urinary Tract Transitional Cell Carcinoma
Upper urinary tract transitional cell carcinoma (UUT-TCC) is quite an uncommon disease, and its prognosis differs among individuals irrespective of tumor stage. DNA repair gene polymorphisms are reported to result in the modulation of the repair capacity and might influence the prognosis of UUT-TCC....
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2008-03-01
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| Series: | Neoplasia: An International Journal for Oncology Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1476558608801224 |
| _version_ | 1818542225586388992 |
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| author | Miwa Sasaki Shigeru Sakano Naoko Okayama Jumpei Akao Tomohiko Hara Yoshihisa Kawai Chietaka Ohmi Yuji Hinoda Katsusuke Naito |
| author_facet | Miwa Sasaki Shigeru Sakano Naoko Okayama Jumpei Akao Tomohiko Hara Yoshihisa Kawai Chietaka Ohmi Yuji Hinoda Katsusuke Naito |
| author_sort | Miwa Sasaki |
| collection | DOAJ |
| description | Upper urinary tract transitional cell carcinoma (UUT-TCC) is quite an uncommon disease, and its prognosis differs among individuals irrespective of tumor stage. DNA repair gene polymorphisms are reported to result in the modulation of the repair capacity and might influence the prognosis of UUT-TCC. We examined the associations between functional polymorphisms in five DNA repair genes, and the prognosis of UUT-TCC in 103 UUT-TCC patients. Variant alleles in xeroderma pigmentosum complementation group C, more than three total variant alleles in all DNA repair genes studied and more than two total variant alleles in three nucleotide excision repair genes were independently associated with improved overall and disease-specific survival of UUT-TCC patients in multivariate analysis (P = .0063 and P = .0005 for xeroderma pigmentosum complementation group C, P = .016 and P = .0016 for all genes, and P = .0053 and P = .018 for nucleotide excision repair genes, respectively). These results suggest that some DNA repair gene polymorphisms may preoperatively be valuable as prognostic factors for UUT-TCC beyond tumor stage and grade, helping to provide optimal treatment strategies for individual patients. |
| first_indexed | 2024-12-11T22:19:19Z |
| format | Article |
| id | doaj.art-d066c1fd29bc42d9b1adaa677105383a |
| institution | Directory Open Access Journal |
| issn | 1476-5586 1522-8002 |
| language | English |
| last_indexed | 2024-12-11T22:19:19Z |
| publishDate | 2008-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neoplasia: An International Journal for Oncology Research |
| spelling | doaj.art-d066c1fd29bc42d9b1adaa677105383a2022-12-22T00:48:31ZengElsevierNeoplasia: An International Journal for Oncology Research1476-55861522-80022008-03-0110325526510.1593/neo.07982DNA Repair Gene Polymorphisms May Be Associated with Prognosis of Upper Urinary Tract Transitional Cell CarcinomaMiwa Sasaki0Shigeru Sakano1Naoko Okayama2Jumpei Akao3Tomohiko Hara4Yoshihisa Kawai5Chietaka Ohmi6Yuji Hinoda7Katsusuke Naito8Department of Urology, Graduate School of Medicine, Yamaguchi University, Ube, JapanDepartment of Urology, Graduate School of Medicine, Yamaguchi University, Ube, JapanDepartment of Laboratory Medicine, Graduate School of Medicine, Yamaguchi University, Ube, JapanDepartment of Urology, Graduate School of Medicine, Yamaguchi University, Ube, JapanDepartment of Urology, Graduate School of Medicine, Yamaguchi University, Ube, JapanDepartment of Urology, Graduate School of Medicine, Yamaguchi University, Ube, JapanDepartment of Urology, Graduate School of Medicine, Yamaguchi University, Ube, JapanDepartment of Laboratory Medicine, Graduate School of Medicine, Yamaguchi University, Ube, JapanDepartment of Urology, Graduate School of Medicine, Yamaguchi University, Ube, JapanUpper urinary tract transitional cell carcinoma (UUT-TCC) is quite an uncommon disease, and its prognosis differs among individuals irrespective of tumor stage. DNA repair gene polymorphisms are reported to result in the modulation of the repair capacity and might influence the prognosis of UUT-TCC. We examined the associations between functional polymorphisms in five DNA repair genes, and the prognosis of UUT-TCC in 103 UUT-TCC patients. Variant alleles in xeroderma pigmentosum complementation group C, more than three total variant alleles in all DNA repair genes studied and more than two total variant alleles in three nucleotide excision repair genes were independently associated with improved overall and disease-specific survival of UUT-TCC patients in multivariate analysis (P = .0063 and P = .0005 for xeroderma pigmentosum complementation group C, P = .016 and P = .0016 for all genes, and P = .0053 and P = .018 for nucleotide excision repair genes, respectively). These results suggest that some DNA repair gene polymorphisms may preoperatively be valuable as prognostic factors for UUT-TCC beyond tumor stage and grade, helping to provide optimal treatment strategies for individual patients.http://www.sciencedirect.com/science/article/pii/S1476558608801224 |
| spellingShingle | Miwa Sasaki Shigeru Sakano Naoko Okayama Jumpei Akao Tomohiko Hara Yoshihisa Kawai Chietaka Ohmi Yuji Hinoda Katsusuke Naito DNA Repair Gene Polymorphisms May Be Associated with Prognosis of Upper Urinary Tract Transitional Cell Carcinoma Neoplasia: An International Journal for Oncology Research |
| title | DNA Repair Gene Polymorphisms May Be Associated with Prognosis of Upper Urinary Tract Transitional Cell Carcinoma |
| title_full | DNA Repair Gene Polymorphisms May Be Associated with Prognosis of Upper Urinary Tract Transitional Cell Carcinoma |
| title_fullStr | DNA Repair Gene Polymorphisms May Be Associated with Prognosis of Upper Urinary Tract Transitional Cell Carcinoma |
| title_full_unstemmed | DNA Repair Gene Polymorphisms May Be Associated with Prognosis of Upper Urinary Tract Transitional Cell Carcinoma |
| title_short | DNA Repair Gene Polymorphisms May Be Associated with Prognosis of Upper Urinary Tract Transitional Cell Carcinoma |
| title_sort | dna repair gene polymorphisms may be associated with prognosis of upper urinary tract transitional cell carcinoma |
| url | http://www.sciencedirect.com/science/article/pii/S1476558608801224 |
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