FDG PET texture indices as imaging biomarkers for epidermal growth factor receptor mutation status in lung adenocarcinoma
Abstract Identifying the epidermal growth factor receptor (EGFR) mutation status is important for the optimal treatment of patients with EGFR mutations. We investigated the relationship between 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) texture indices and EGFR mutation status i...
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| Format: | Article |
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Nature Portfolio
2023-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-34061-7 |
| _version_ | 1797836442107379712 |
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| author | Mariko Ishimura Takashi Norikane Katsuya Mitamura Yuka Yamamoto Yuri Manabe Mitsumasa Murao Makiko Murota Nobuhiro Kanaji Yoshihiro Nishiyama |
| author_facet | Mariko Ishimura Takashi Norikane Katsuya Mitamura Yuka Yamamoto Yuri Manabe Mitsumasa Murao Makiko Murota Nobuhiro Kanaji Yoshihiro Nishiyama |
| author_sort | Mariko Ishimura |
| collection | DOAJ |
| description | Abstract Identifying the epidermal growth factor receptor (EGFR) mutation status is important for the optimal treatment of patients with EGFR mutations. We investigated the relationship between 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) texture indices and EGFR mutation status in patients with newly diagnosed lung adenocarcinoma. We retrospectively analyzed data of patients with newly diagnosed lung adenocarcinoma who underwent pretreatment FDG PET/computed tomography and EGFR mutation testing between August 2014 and November 2020. Patients were divided into mutated EGFR and wild-type EGFR groups. The maximum standardized uptake value (SUVmax) and 31 texture indices for the primary tumor were calculated from PET images and compared between the two groups. Of the 66 patients included, 22 had mutated EGFR and 44 had wild-type EGFR. The SUVmax did not significantly differ between the two groups. Among the 31 evaluated texture indices, the following five showed a statistically significant difference between the groups: correlation (P = 0.003), gray-level nonuniformity for run (P = 0.042), run length nonuniformity (P = 0.02), coarseness (P = 0.006), and gray-level nonuniformity for zone (P = 0.04). Based on the preliminary results of this study in a small patient population, FDG PET texture indices may be potential imaging biomarkers for the EGFR mutation status in patients with newly diagnosed lung adenocarcinoma. |
| first_indexed | 2024-04-09T15:10:06Z |
| format | Article |
| id | doaj.art-d067c24dd2934512ace42de77cbbf4cc |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T15:10:06Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-d067c24dd2934512ace42de77cbbf4cc2023-04-30T11:17:18ZengNature PortfolioScientific Reports2045-23222023-04-011311710.1038/s41598-023-34061-7FDG PET texture indices as imaging biomarkers for epidermal growth factor receptor mutation status in lung adenocarcinomaMariko Ishimura0Takashi Norikane1Katsuya Mitamura2Yuka Yamamoto3Yuri Manabe4Mitsumasa Murao5Makiko Murota6Nobuhiro Kanaji7Yoshihiro Nishiyama8Department of Radiology, Faculty of Medicine, Kagawa UniversityDepartment of Radiology, Faculty of Medicine, Kagawa UniversityDepartment of Radiology, Faculty of Medicine, Kagawa UniversityDepartment of Radiology, Faculty of Medicine, Kagawa UniversityDepartment of Radiology, Faculty of Medicine, Kagawa UniversityDepartment of Radiology, Faculty of Medicine, Kagawa UniversityDepartment of Radiology, Faculty of Medicine, Kagawa UniversityDivision of Hematology, Rheumatology, and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa UniversityDepartment of Radiology, Faculty of Medicine, Kagawa UniversityAbstract Identifying the epidermal growth factor receptor (EGFR) mutation status is important for the optimal treatment of patients with EGFR mutations. We investigated the relationship between 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) texture indices and EGFR mutation status in patients with newly diagnosed lung adenocarcinoma. We retrospectively analyzed data of patients with newly diagnosed lung adenocarcinoma who underwent pretreatment FDG PET/computed tomography and EGFR mutation testing between August 2014 and November 2020. Patients were divided into mutated EGFR and wild-type EGFR groups. The maximum standardized uptake value (SUVmax) and 31 texture indices for the primary tumor were calculated from PET images and compared between the two groups. Of the 66 patients included, 22 had mutated EGFR and 44 had wild-type EGFR. The SUVmax did not significantly differ between the two groups. Among the 31 evaluated texture indices, the following five showed a statistically significant difference between the groups: correlation (P = 0.003), gray-level nonuniformity for run (P = 0.042), run length nonuniformity (P = 0.02), coarseness (P = 0.006), and gray-level nonuniformity for zone (P = 0.04). Based on the preliminary results of this study in a small patient population, FDG PET texture indices may be potential imaging biomarkers for the EGFR mutation status in patients with newly diagnosed lung adenocarcinoma.https://doi.org/10.1038/s41598-023-34061-7 |
| spellingShingle | Mariko Ishimura Takashi Norikane Katsuya Mitamura Yuka Yamamoto Yuri Manabe Mitsumasa Murao Makiko Murota Nobuhiro Kanaji Yoshihiro Nishiyama FDG PET texture indices as imaging biomarkers for epidermal growth factor receptor mutation status in lung adenocarcinoma Scientific Reports |
| title | FDG PET texture indices as imaging biomarkers for epidermal growth factor receptor mutation status in lung adenocarcinoma |
| title_full | FDG PET texture indices as imaging biomarkers for epidermal growth factor receptor mutation status in lung adenocarcinoma |
| title_fullStr | FDG PET texture indices as imaging biomarkers for epidermal growth factor receptor mutation status in lung adenocarcinoma |
| title_full_unstemmed | FDG PET texture indices as imaging biomarkers for epidermal growth factor receptor mutation status in lung adenocarcinoma |
| title_short | FDG PET texture indices as imaging biomarkers for epidermal growth factor receptor mutation status in lung adenocarcinoma |
| title_sort | fdg pet texture indices as imaging biomarkers for epidermal growth factor receptor mutation status in lung adenocarcinoma |
| url | https://doi.org/10.1038/s41598-023-34061-7 |
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