Complementing canonical fMRI with functional Quantitative Susceptibility Mapping (fQSM) in modern neuroimaging research
Functional Quantitative Susceptibility Mapping (fQSM) allows for the quantitative measurement of time-varying magnetic susceptibility across cortical and subcortical brain structures with a potentially higher spatial specificity than conventional fMRI. While the usefulness of fQSM with General Linea...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-12-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811921008478 |
| _version_ | 1819005326965342208 |
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| author | Marta Lancione Mauro Costagli Giacomo Handjaras Michela Tosetti Emiliano Ricciardi Pietro Pietrini Luca Cecchetti |
| author_facet | Marta Lancione Mauro Costagli Giacomo Handjaras Michela Tosetti Emiliano Ricciardi Pietro Pietrini Luca Cecchetti |
| author_sort | Marta Lancione |
| collection | DOAJ |
| description | Functional Quantitative Susceptibility Mapping (fQSM) allows for the quantitative measurement of time-varying magnetic susceptibility across cortical and subcortical brain structures with a potentially higher spatial specificity than conventional fMRI. While the usefulness of fQSM with General Linear Model and “On/Off” paradigms has been assessed, little is known about the potential applications and limitations of this technique in more sophisticated experimental paradigms and analyses, such as those currently used in modern neuroimaging.To thoroughly characterize fQSM activations, here we used 7T MRI, tonotopic mapping, as well as univariate (i.e., GLM and population Receptive Field) and multivariate (Representational Similarity Analysis; RSA) analyses.Although fQSM detected less tone-responsive voxels than fMRI, they were more consistently localized in gray matter. Also, the majority of active gray matter voxels exhibited negative fQSM response, signaling the expected oxyhemoglobin increase, whereas positive fQSM activations were mainly in white matter. Though fMRI- and fQSM-based tonotopic maps were overall comparable, the representation of frequency tunings in tone-sensitive regions was significantly more balanced for fQSM. Lastly, RSA revealed that frequency information from the auditory cortex could be successfully retrieved by using either methods.Overall, fQSM produces complementary results to conventional fMRI, as it captures small-scale variations in the activation pattern which inform multivariate measures. Although positive fQSM responses deserve further investigation, they do not impair the interpretation of contrasts of interest. The quantitative nature of fQSM, its spatial specificity and the possibility to simultaneously acquire canonical fMRI support the use of this technique for longitudinal and multicentric studies and pre-surgical mapping. |
| first_indexed | 2024-12-20T23:51:01Z |
| format | Article |
| id | doaj.art-d068904bae15477393627762e96de585 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-12-20T23:51:01Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-d068904bae15477393627762e96de5852022-12-21T19:22:50ZengElsevierNeuroImage1095-95722021-12-01244118574Complementing canonical fMRI with functional Quantitative Susceptibility Mapping (fQSM) in modern neuroimaging researchMarta Lancione0Mauro Costagli1Giacomo Handjaras2Michela Tosetti3Emiliano Ricciardi4Pietro Pietrini5Luca Cecchetti6MoMiLab, IMT School for Advanced Studies Lucca, Piazza San Francesco, 19, Lucca 55100, Italy; IMAGO7 Foundation, Pisa, Italy; Corresponding author at: MoMiLab, IMT School for Advanced Studies Lucca, Piazza San Francesco, 19, Lucca 55100, Italy.Laboratory of Medical Physics and Magnetic Resonance, IRCCS Fondazione Stella Maris, Pisa, Italy; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Sciences (DINOGMI), University of Genoa, Genoa, ItalySocial and Affective Neuroscience (SANe) Group, MoMiLab, IMT School for Advanced Studies Lucca, Lucca, ItalyIMAGO7 Foundation, Pisa, Italy; Laboratory of Medical Physics and Magnetic Resonance, IRCCS Fondazione Stella Maris, Pisa, ItalyMoMiLab, IMT School for Advanced Studies Lucca, Piazza San Francesco, 19, Lucca 55100, ItalyMoMiLab, IMT School for Advanced Studies Lucca, Piazza San Francesco, 19, Lucca 55100, ItalySocial and Affective Neuroscience (SANe) Group, MoMiLab, IMT School for Advanced Studies Lucca, Lucca, ItalyFunctional Quantitative Susceptibility Mapping (fQSM) allows for the quantitative measurement of time-varying magnetic susceptibility across cortical and subcortical brain structures with a potentially higher spatial specificity than conventional fMRI. While the usefulness of fQSM with General Linear Model and “On/Off” paradigms has been assessed, little is known about the potential applications and limitations of this technique in more sophisticated experimental paradigms and analyses, such as those currently used in modern neuroimaging.To thoroughly characterize fQSM activations, here we used 7T MRI, tonotopic mapping, as well as univariate (i.e., GLM and population Receptive Field) and multivariate (Representational Similarity Analysis; RSA) analyses.Although fQSM detected less tone-responsive voxels than fMRI, they were more consistently localized in gray matter. Also, the majority of active gray matter voxels exhibited negative fQSM response, signaling the expected oxyhemoglobin increase, whereas positive fQSM activations were mainly in white matter. Though fMRI- and fQSM-based tonotopic maps were overall comparable, the representation of frequency tunings in tone-sensitive regions was significantly more balanced for fQSM. Lastly, RSA revealed that frequency information from the auditory cortex could be successfully retrieved by using either methods.Overall, fQSM produces complementary results to conventional fMRI, as it captures small-scale variations in the activation pattern which inform multivariate measures. Although positive fQSM responses deserve further investigation, they do not impair the interpretation of contrasts of interest. The quantitative nature of fQSM, its spatial specificity and the possibility to simultaneously acquire canonical fMRI support the use of this technique for longitudinal and multicentric studies and pre-surgical mapping.http://www.sciencedirect.com/science/article/pii/S1053811921008478Quantitative Susceptibility MappingFunctional QSMfMRISpatial specificityQuantitative BOLDTonotopic mapping |
| spellingShingle | Marta Lancione Mauro Costagli Giacomo Handjaras Michela Tosetti Emiliano Ricciardi Pietro Pietrini Luca Cecchetti Complementing canonical fMRI with functional Quantitative Susceptibility Mapping (fQSM) in modern neuroimaging research NeuroImage Quantitative Susceptibility Mapping Functional QSM fMRI Spatial specificity Quantitative BOLD Tonotopic mapping |
| title | Complementing canonical fMRI with functional Quantitative Susceptibility Mapping (fQSM) in modern neuroimaging research |
| title_full | Complementing canonical fMRI with functional Quantitative Susceptibility Mapping (fQSM) in modern neuroimaging research |
| title_fullStr | Complementing canonical fMRI with functional Quantitative Susceptibility Mapping (fQSM) in modern neuroimaging research |
| title_full_unstemmed | Complementing canonical fMRI with functional Quantitative Susceptibility Mapping (fQSM) in modern neuroimaging research |
| title_short | Complementing canonical fMRI with functional Quantitative Susceptibility Mapping (fQSM) in modern neuroimaging research |
| title_sort | complementing canonical fmri with functional quantitative susceptibility mapping fqsm in modern neuroimaging research |
| topic | Quantitative Susceptibility Mapping Functional QSM fMRI Spatial specificity Quantitative BOLD Tonotopic mapping |
| url | http://www.sciencedirect.com/science/article/pii/S1053811921008478 |
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