Synthesis, Drug Release, and Antibacterial Properties of Novel Dendritic CHX-SrCl<sub>2</sub> and CHX-ZnCl<sub>2</sub> Particles
This work demonstrated for the first time the synthesis of novel chlorhexidine particles containing strontium and zinc, to provide an effective, affordable, and safe intervention in the treatment of recurrent infections found in Medicine and Dentistry. The CHX-SrCl<sub>2</sub> and CHX-Zn...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/11/1799 |
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| author | Rui Sun Jiaxin Zhang Robert A. Whiley Gleb B. Sukhorukov Michael J. Cattell |
| author_facet | Rui Sun Jiaxin Zhang Robert A. Whiley Gleb B. Sukhorukov Michael J. Cattell |
| author_sort | Rui Sun |
| collection | DOAJ |
| description | This work demonstrated for the first time the synthesis of novel chlorhexidine particles containing strontium and zinc, to provide an effective, affordable, and safe intervention in the treatment of recurrent infections found in Medicine and Dentistry. The CHX-SrCl<sub>2</sub> and CHX-ZnCl<sub>2</sub> particles were synthesized by co-precipitation of chlorhexidine diacetate (CHXD) and zinc chloride or strontium chloride, where particle size was manipulated by controlling processing time and temperature. The CHX-ZnCl<sub>2</sub> and CHX-SrCl<sub>2</sub> particles were characterized using SEM, FTIR, and XRD. UV-Vis using artificial saliva (pH 4 and pH 7) was used to measure the drug release and ICP-OES ion release. The antibacterial properties were examined against <i>P. gingivalis</i>, <i>A. actinomycetemcomitans</i>, and <i>F. nucleatum subsp. Polymorphum</i>, and cytotoxicity was evaluated using mouse fibroblast L929 cells. The novel particles were as safe as commercial CHXD, with antibacterial activity against a range of oral pathogens. UV-Vis results run in artificial saliva (pH 4 and pH 7) indicated a higher release rate in acidic rather than neutral conditions. The CHX-ZnCl<sub>2</sub> particles provided the functionality of a smart Zinc and CHX release, with respect to environmental pH, allowing responsive antibacterial applications in the field of medicine and dentistry. |
| first_indexed | 2024-03-10T05:09:21Z |
| format | Article |
| id | doaj.art-d06b65a938ef4316945fc2c2410df21b |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T05:09:21Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-d06b65a938ef4316945fc2c2410df21b2023-11-23T00:57:48ZengMDPI AGPharmaceutics1999-49232021-10-011311179910.3390/pharmaceutics13111799Synthesis, Drug Release, and Antibacterial Properties of Novel Dendritic CHX-SrCl<sub>2</sub> and CHX-ZnCl<sub>2</sub> ParticlesRui Sun0Jiaxin Zhang1Robert A. Whiley2Gleb B. Sukhorukov3Michael J. Cattell4Centre for Oral Bioengineering, Bart’s and the London, School of Medicine and Dentistry, Queen Mary University of London, Turner Street, London E1 2AD, UKSchool of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, UKCentre for Oral Immunobiology and Regenerative Medicine, Bart’s and the London, School of Medicine and Dentistry, Queen Mary University of London, Blizzard Building, 4 Newark Street, London E1 2AT, UKSchool of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, UKCentre for Oral Bioengineering, Bart’s and the London, School of Medicine and Dentistry, Queen Mary University of London, Turner Street, London E1 2AD, UKThis work demonstrated for the first time the synthesis of novel chlorhexidine particles containing strontium and zinc, to provide an effective, affordable, and safe intervention in the treatment of recurrent infections found in Medicine and Dentistry. The CHX-SrCl<sub>2</sub> and CHX-ZnCl<sub>2</sub> particles were synthesized by co-precipitation of chlorhexidine diacetate (CHXD) and zinc chloride or strontium chloride, where particle size was manipulated by controlling processing time and temperature. The CHX-ZnCl<sub>2</sub> and CHX-SrCl<sub>2</sub> particles were characterized using SEM, FTIR, and XRD. UV-Vis using artificial saliva (pH 4 and pH 7) was used to measure the drug release and ICP-OES ion release. The antibacterial properties were examined against <i>P. gingivalis</i>, <i>A. actinomycetemcomitans</i>, and <i>F. nucleatum subsp. Polymorphum</i>, and cytotoxicity was evaluated using mouse fibroblast L929 cells. The novel particles were as safe as commercial CHXD, with antibacterial activity against a range of oral pathogens. UV-Vis results run in artificial saliva (pH 4 and pH 7) indicated a higher release rate in acidic rather than neutral conditions. The CHX-ZnCl<sub>2</sub> particles provided the functionality of a smart Zinc and CHX release, with respect to environmental pH, allowing responsive antibacterial applications in the field of medicine and dentistry.https://www.mdpi.com/1999-4923/13/11/1799chlorhexidinedrug deliverycontrolled releaseparticulate delivery systemsantibacterial |
| spellingShingle | Rui Sun Jiaxin Zhang Robert A. Whiley Gleb B. Sukhorukov Michael J. Cattell Synthesis, Drug Release, and Antibacterial Properties of Novel Dendritic CHX-SrCl<sub>2</sub> and CHX-ZnCl<sub>2</sub> Particles Pharmaceutics chlorhexidine drug delivery controlled release particulate delivery systems antibacterial |
| title | Synthesis, Drug Release, and Antibacterial Properties of Novel Dendritic CHX-SrCl<sub>2</sub> and CHX-ZnCl<sub>2</sub> Particles |
| title_full | Synthesis, Drug Release, and Antibacterial Properties of Novel Dendritic CHX-SrCl<sub>2</sub> and CHX-ZnCl<sub>2</sub> Particles |
| title_fullStr | Synthesis, Drug Release, and Antibacterial Properties of Novel Dendritic CHX-SrCl<sub>2</sub> and CHX-ZnCl<sub>2</sub> Particles |
| title_full_unstemmed | Synthesis, Drug Release, and Antibacterial Properties of Novel Dendritic CHX-SrCl<sub>2</sub> and CHX-ZnCl<sub>2</sub> Particles |
| title_short | Synthesis, Drug Release, and Antibacterial Properties of Novel Dendritic CHX-SrCl<sub>2</sub> and CHX-ZnCl<sub>2</sub> Particles |
| title_sort | synthesis drug release and antibacterial properties of novel dendritic chx srcl sub 2 sub and chx zncl sub 2 sub particles |
| topic | chlorhexidine drug delivery controlled release particulate delivery systems antibacterial |
| url | https://www.mdpi.com/1999-4923/13/11/1799 |
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