Evaluation of Salivary Nitric Oxide Levels in Smokers, Tobacco Chewers and Patients with Oral Lichenoid Reactions
Introduction: Nitric oxide (NO), a free radical, acts as a signalling molecule affecting numerous physiological and pathological processes. Role of nitric oxide as a mediator in tobacco related habits and the resultant oral lichenoid reactions was assessed. Aim: The aim of the study is to evalua...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-01-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/7126/16517_CE[Ra]_F(Sh)_PF1(VSUAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Introduction: Nitric oxide (NO), a free radical, acts as a signalling
molecule affecting numerous physiological and pathological
processes. Role of nitric oxide as a mediator in tobacco related
habits and the resultant oral lichenoid reactions was assessed.
Aim: The aim of the study is to evaluate and compare the salivary
nitric oxide levels in normal patients with that of smokers,
tobacco chewers and patients with oral lichenoid reactions.
Materials and Methods: One hundred and twenty patients
were enrolled in the study which included 30 healthy patients
without any chronic inflammatory lesion and habit as controls
(group I), 30 smokers without the habit of tobacco/betel nut
chewing and any oral lesion (group II), 30 tobacco chewers
without the habit of smoking and any oral lesion (group III) and
30 histologically confirmed cases of oral lichenoid reaction with
the habit of tobacco usage (group IV). Saliva from these patients
was collected and the nitrite concentration was assessed.
Results: Our results concluded that there was highly significant
increase in the nitric oxide levels in smokers, tobacco chewers
and patients with oral lichenoid reactions compared to that of
controls. Also, there was a significant increase in nitric oxide
levels in patients with smoking associated oral lichenoid
reactions in comparison with smokers and in patients with
lichenoid reactions associated with tobacco chewing in
comparison with tobacco chewers.
Conclusion: Estimation of salivary nitric oxide levels is a simple,
non-invasive procedure and could be analysed to suggest the
role of nitric oxide in the pathogenesis of these lesions. The
increased activity of the enzyme may indicate that nitric oxide
has a pathophysiological role in these lesions. |
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| ISSN: | 2249-782X 0973-709X |