Evaluation of Salivary Nitric Oxide Levels in Smokers, Tobacco Chewers and Patients with Oral Lichenoid Reactions
Introduction: Nitric oxide (NO), a free radical, acts as a signalling molecule affecting numerous physiological and pathological processes. Role of nitric oxide as a mediator in tobacco related habits and the resultant oral lichenoid reactions was assessed. Aim: The aim of the study is to evalua...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2016-01-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/7126/16517_CE[Ra]_F(Sh)_PF1(VSUAK)_PFA(AK)_PF2(PAG).pdf |
| _version_ | 1818907495049986048 |
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| author | S. Preethi Joy Idiculla Jose B. Sivapathasundharam B. Sabarinath |
| author_facet | S. Preethi Joy Idiculla Jose B. Sivapathasundharam B. Sabarinath |
| author_sort | S. Preethi |
| collection | DOAJ |
| description | Introduction: Nitric oxide (NO), a free radical, acts as a signalling
molecule affecting numerous physiological and pathological
processes. Role of nitric oxide as a mediator in tobacco related
habits and the resultant oral lichenoid reactions was assessed.
Aim: The aim of the study is to evaluate and compare the salivary
nitric oxide levels in normal patients with that of smokers,
tobacco chewers and patients with oral lichenoid reactions.
Materials and Methods: One hundred and twenty patients
were enrolled in the study which included 30 healthy patients
without any chronic inflammatory lesion and habit as controls
(group I), 30 smokers without the habit of tobacco/betel nut
chewing and any oral lesion (group II), 30 tobacco chewers
without the habit of smoking and any oral lesion (group III) and
30 histologically confirmed cases of oral lichenoid reaction with
the habit of tobacco usage (group IV). Saliva from these patients
was collected and the nitrite concentration was assessed.
Results: Our results concluded that there was highly significant
increase in the nitric oxide levels in smokers, tobacco chewers
and patients with oral lichenoid reactions compared to that of
controls. Also, there was a significant increase in nitric oxide
levels in patients with smoking associated oral lichenoid
reactions in comparison with smokers and in patients with
lichenoid reactions associated with tobacco chewing in
comparison with tobacco chewers.
Conclusion: Estimation of salivary nitric oxide levels is a simple,
non-invasive procedure and could be analysed to suggest the
role of nitric oxide in the pathogenesis of these lesions. The
increased activity of the enzyme may indicate that nitric oxide
has a pathophysiological role in these lesions. |
| first_indexed | 2024-12-19T21:56:01Z |
| format | Article |
| id | doaj.art-d06f38b14d8044849c1587ed58a1a090 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-19T21:56:01Z |
| publishDate | 2016-01-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-d06f38b14d8044849c1587ed58a1a0902022-12-21T20:04:17ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-01-01101ZC63ZC6610.7860/JCDR/2016/16517.7126Evaluation of Salivary Nitric Oxide Levels in Smokers, Tobacco Chewers and Patients with Oral Lichenoid ReactionsS. Preethi0Joy Idiculla Jose1B. Sivapathasundharam2B. Sabarinath3Senior Lecturer, Department of Oral Pathology, Meenakshi Ammal Dental College, Chennai, India.Head of Department, Department of Oral Pathology, Faculty of Dentistry, Melaka Manipal Medical College, India.Head of the Department, Department of Oral Pathology, Meenakshi Ammal Dental College, Chennai, India.Reader, Department of Oral Pathology, Meenakshi Ammal Dental College, Chennai, India.Introduction: Nitric oxide (NO), a free radical, acts as a signalling molecule affecting numerous physiological and pathological processes. Role of nitric oxide as a mediator in tobacco related habits and the resultant oral lichenoid reactions was assessed. Aim: The aim of the study is to evaluate and compare the salivary nitric oxide levels in normal patients with that of smokers, tobacco chewers and patients with oral lichenoid reactions. Materials and Methods: One hundred and twenty patients were enrolled in the study which included 30 healthy patients without any chronic inflammatory lesion and habit as controls (group I), 30 smokers without the habit of tobacco/betel nut chewing and any oral lesion (group II), 30 tobacco chewers without the habit of smoking and any oral lesion (group III) and 30 histologically confirmed cases of oral lichenoid reaction with the habit of tobacco usage (group IV). Saliva from these patients was collected and the nitrite concentration was assessed. Results: Our results concluded that there was highly significant increase in the nitric oxide levels in smokers, tobacco chewers and patients with oral lichenoid reactions compared to that of controls. Also, there was a significant increase in nitric oxide levels in patients with smoking associated oral lichenoid reactions in comparison with smokers and in patients with lichenoid reactions associated with tobacco chewing in comparison with tobacco chewers. Conclusion: Estimation of salivary nitric oxide levels is a simple, non-invasive procedure and could be analysed to suggest the role of nitric oxide in the pathogenesis of these lesions. The increased activity of the enzyme may indicate that nitric oxide has a pathophysiological role in these lesions.https://jcdr.net/articles/PDF/7126/16517_CE[Ra]_F(Sh)_PF1(VSUAK)_PFA(AK)_PF2(PAG).pdfbetel nutlichen planussalivasmoking |
| spellingShingle | S. Preethi Joy Idiculla Jose B. Sivapathasundharam B. Sabarinath Evaluation of Salivary Nitric Oxide Levels in Smokers, Tobacco Chewers and Patients with Oral Lichenoid Reactions Journal of Clinical and Diagnostic Research betel nut lichen planus saliva smoking |
| title | Evaluation of Salivary Nitric Oxide Levels in Smokers, Tobacco Chewers and Patients with Oral Lichenoid Reactions |
| title_full | Evaluation of Salivary Nitric Oxide Levels in Smokers, Tobacco Chewers and Patients with Oral Lichenoid Reactions |
| title_fullStr | Evaluation of Salivary Nitric Oxide Levels in Smokers, Tobacco Chewers and Patients with Oral Lichenoid Reactions |
| title_full_unstemmed | Evaluation of Salivary Nitric Oxide Levels in Smokers, Tobacco Chewers and Patients with Oral Lichenoid Reactions |
| title_short | Evaluation of Salivary Nitric Oxide Levels in Smokers, Tobacco Chewers and Patients with Oral Lichenoid Reactions |
| title_sort | evaluation of salivary nitric oxide levels in smokers tobacco chewers and patients with oral lichenoid reactions |
| topic | betel nut lichen planus saliva smoking |
| url | https://jcdr.net/articles/PDF/7126/16517_CE[Ra]_F(Sh)_PF1(VSUAK)_PFA(AK)_PF2(PAG).pdf |
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