Senescent cells form nuclear foci that contain the 26S proteasome

Senescent cells form nuclear foci that contain the 26S proteasome

Summary: The proteasome plays a central role in intracellular protein degradation. Age-dependent decline in proteasome activity is associated with cellular senescence and organismal aging; however, the mechanism by which the proteasome plays a role in senescent cells remains elusive. Here, we show t...

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Bibliographic Details
Main Authors: Tomohiro Iriki, Hiroaki Iio, Shu Yasuda, Shun Masuta, Masakazu Kato, Hidetaka Kosako, Shoshiro Hirayama, Akinori Endo, Fumiaki Ohtake, Mako Kamiya, Yasuteru Urano, Yasushi Saeki, Jun Hamazaki, Shigeo Murata
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Cell Reports
Subjects:
CP: Cell biology
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723008914

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