The developmental relationship between specific cognitive domains and grey matter in the cerebellum
There is growing evidence that the cerebellum is involved in cognition and cognitive development, yet little is known about the developmental relationship between cerebellar structure and cognitive subdomains in children. We used voxel-based morphometry to assess the relationship between cerebellar...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-04-01
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| Series: | Developmental Cognitive Neuroscience |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929316301268 |
| _version_ | 1818337601029931008 |
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| author | Dorothea M. Moore Anila M. D’Mello Lauren M. McGrath Catherine J. Stoodley |
| author_facet | Dorothea M. Moore Anila M. D’Mello Lauren M. McGrath Catherine J. Stoodley |
| author_sort | Dorothea M. Moore |
| collection | DOAJ |
| description | There is growing evidence that the cerebellum is involved in cognition and cognitive development, yet little is known about the developmental relationship between cerebellar structure and cognitive subdomains in children. We used voxel-based morphometry to assess the relationship between cerebellar grey matter (GM) and language, reading, working memory, executive function, and processing speed in 110 individuals aged 8–17 years from the Pediatric Imaging, Neurocognition, and Genetics (PING) Study. Further, we examined the effect of age on the relationships between cerebellar GM and cognition. Higher scores on vocabulary, reading, working memory, and set-shifting were associated with increased GM in the posterior cerebellum (lobules VI–IX), in regions which are typically engaged during cognitive tasks in healthy adults. For reading, working memory, and processing speed, the relationship between cerebellar GM and cognitive performance changed with age in specific cerebellar subregions. As in adults, posterior lobe cerebellar GM was associated with cognitive performance in a pediatric population, and this relationship mirrored the known developmental trajectory of posterior cerebellar GM. These findings provide further evidence that specific regions of the cerebellum support cognition and cognitive development, and suggest that the strength of this relationship depends on developmental stage. Keywords: Cerebellum, Developmental imaging, Cognition, Voxel based morphometry, PING, NIH toolbox |
| first_indexed | 2024-12-13T14:57:48Z |
| format | Article |
| id | doaj.art-d072645e27e4408891bc1e0a2b59fbb4 |
| institution | Directory Open Access Journal |
| issn | 1878-9293 |
| language | English |
| last_indexed | 2024-12-13T14:57:48Z |
| publishDate | 2017-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-d072645e27e4408891bc1e0a2b59fbb42022-12-21T23:41:12ZengElsevierDevelopmental Cognitive Neuroscience1878-92932017-04-0124111The developmental relationship between specific cognitive domains and grey matter in the cerebellumDorothea M. Moore0Anila M. D’Mello1Lauren M. McGrath2Catherine J. Stoodley3Department of Psychology, American University, Washington, DC, USADepartment of Psychology, American University, Washington, DC, USASchool of Education, American University, Washington, DC, USA; Center for Behavioral Neuroscience, American University, Washington, DC, USA; Department of Psychology, University of Denver, Denver, CO, USADepartment of Psychology, American University, Washington, DC, USA; Center for Behavioral Neuroscience, American University, Washington, DC, USA; Corresponding author at: Department of Psychology, American University, 4400 Massachusetts Ave, NW, Washington, DC 20016, USA.There is growing evidence that the cerebellum is involved in cognition and cognitive development, yet little is known about the developmental relationship between cerebellar structure and cognitive subdomains in children. We used voxel-based morphometry to assess the relationship between cerebellar grey matter (GM) and language, reading, working memory, executive function, and processing speed in 110 individuals aged 8–17 years from the Pediatric Imaging, Neurocognition, and Genetics (PING) Study. Further, we examined the effect of age on the relationships between cerebellar GM and cognition. Higher scores on vocabulary, reading, working memory, and set-shifting were associated with increased GM in the posterior cerebellum (lobules VI–IX), in regions which are typically engaged during cognitive tasks in healthy adults. For reading, working memory, and processing speed, the relationship between cerebellar GM and cognitive performance changed with age in specific cerebellar subregions. As in adults, posterior lobe cerebellar GM was associated with cognitive performance in a pediatric population, and this relationship mirrored the known developmental trajectory of posterior cerebellar GM. These findings provide further evidence that specific regions of the cerebellum support cognition and cognitive development, and suggest that the strength of this relationship depends on developmental stage. Keywords: Cerebellum, Developmental imaging, Cognition, Voxel based morphometry, PING, NIH toolboxhttp://www.sciencedirect.com/science/article/pii/S1878929316301268 |
| spellingShingle | Dorothea M. Moore Anila M. D’Mello Lauren M. McGrath Catherine J. Stoodley The developmental relationship between specific cognitive domains and grey matter in the cerebellum Developmental Cognitive Neuroscience |
| title | The developmental relationship between specific cognitive domains and grey matter in the cerebellum |
| title_full | The developmental relationship between specific cognitive domains and grey matter in the cerebellum |
| title_fullStr | The developmental relationship between specific cognitive domains and grey matter in the cerebellum |
| title_full_unstemmed | The developmental relationship between specific cognitive domains and grey matter in the cerebellum |
| title_short | The developmental relationship between specific cognitive domains and grey matter in the cerebellum |
| title_sort | developmental relationship between specific cognitive domains and grey matter in the cerebellum |
| url | http://www.sciencedirect.com/science/article/pii/S1878929316301268 |
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