Morphodynamics facilitate cancer cells to navigate 3D extracellular matrix

Abstract Cell shape is linked to cell function. The significance of cell morphodynamics, namely the temporal fluctuation of cell shape, is much less understood. Here we study the morphodynamics of MDA-MB-231 cells in type I collagen extracellular matrix (ECM). We systematically vary ECM physical pro...

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Bibliographic Details
Main Authors: Christopher Z. Eddy, Helena Raposo, Aayushi Manchanda, Ryan Wong, Fuxin Li, Bo Sun
Format: Article
Language:English
Published: Nature Portfolio 2021-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-99902-9