Altered MiRNA Expression in Gastric Cancer: a Systematic Review and Meta-Analysis
Background/Aims: Aberrant microRNA expression has the potential to be used for early diagnosis of gastric cancer or to predict survival and treatment response. This study performed a systematic review and meta-analysis of altered miRNAs in gastric cancer in order to assess the use of miRNAs as novel...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Cell Physiol Biochem Press GmbH & Co KG
2015-01-01
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| Series: | Cellular Physiology and Biochemistry |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/369750 |
| _version_ | 1819266750927077376 |
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| author | Qi-Xian Wang You-Qing Zhu Hu Zhang Jun Xiao |
| author_facet | Qi-Xian Wang You-Qing Zhu Hu Zhang Jun Xiao |
| author_sort | Qi-Xian Wang |
| collection | DOAJ |
| description | Background/Aims: Aberrant microRNA expression has the potential to be used for early diagnosis of gastric cancer or to predict survival and treatment response. This study performed a systematic review and meta-analysis of altered miRNAs in gastric cancer in order to assess the use of miRNAs as novel biomarkers for early detection and prognosis prediction of gastric cancer. Methods: We retrieved published articles from the PubMed online database and obtained different sets of data on miRNAs expression profiling in gastric cancer and highlighted the most frequently dysregulated miRNAs in gastric cancer. We then extracted studies that used quantitative RT-PCR and then pooled them together by using meta-disc software (version 1.4). Results: We found that there were 47 aberrantly expressed miRNAs in gastric cancer (29 up-regulated and 18 down-regulated) that were most frequently reported in the literature. In publications that provided information on specific miRNA expression vs. diagnostic value, the pooled data showed good sensitivity and specificity as well as high levels of overall accuracy. However, specimen types could be a factor that introduces substantial heterogeneity. Published studies also showed association of altered miRNA expression with clinicopathological data from gastric cancer patients. Conclusion: Thus, various miRNAs are differentially expressed in gastric cancer and some of them could be further evaluated as biomarkers for early diagnosis of gastric cancer and prediction of prognosis or treatment response. |
| first_indexed | 2024-12-23T21:06:15Z |
| format | Article |
| id | doaj.art-d075d4dbfe8e449ea9f4563c95fd4670 |
| institution | Directory Open Access Journal |
| issn | 1015-8987 1421-9778 |
| language | English |
| last_indexed | 2024-12-23T21:06:15Z |
| publishDate | 2015-01-01 |
| publisher | Cell Physiol Biochem Press GmbH & Co KG |
| record_format | Article |
| series | Cellular Physiology and Biochemistry |
| spelling | doaj.art-d075d4dbfe8e449ea9f4563c95fd46702022-12-21T17:31:12ZengCell Physiol Biochem Press GmbH & Co KGCellular Physiology and Biochemistry1015-89871421-97782015-01-0135393394410.1159/000369750369750Altered MiRNA Expression in Gastric Cancer: a Systematic Review and Meta-AnalysisQi-Xian WangYou-Qing ZhuHu ZhangJun XiaoBackground/Aims: Aberrant microRNA expression has the potential to be used for early diagnosis of gastric cancer or to predict survival and treatment response. This study performed a systematic review and meta-analysis of altered miRNAs in gastric cancer in order to assess the use of miRNAs as novel biomarkers for early detection and prognosis prediction of gastric cancer. Methods: We retrieved published articles from the PubMed online database and obtained different sets of data on miRNAs expression profiling in gastric cancer and highlighted the most frequently dysregulated miRNAs in gastric cancer. We then extracted studies that used quantitative RT-PCR and then pooled them together by using meta-disc software (version 1.4). Results: We found that there were 47 aberrantly expressed miRNAs in gastric cancer (29 up-regulated and 18 down-regulated) that were most frequently reported in the literature. In publications that provided information on specific miRNA expression vs. diagnostic value, the pooled data showed good sensitivity and specificity as well as high levels of overall accuracy. However, specimen types could be a factor that introduces substantial heterogeneity. Published studies also showed association of altered miRNA expression with clinicopathological data from gastric cancer patients. Conclusion: Thus, various miRNAs are differentially expressed in gastric cancer and some of them could be further evaluated as biomarkers for early diagnosis of gastric cancer and prediction of prognosis or treatment response.http://www.karger.com/Article/FullText/369750DiagnosisGastric cancerMiRNAMicroarrayBiomarker |
| spellingShingle | Qi-Xian Wang You-Qing Zhu Hu Zhang Jun Xiao Altered MiRNA Expression in Gastric Cancer: a Systematic Review and Meta-Analysis Cellular Physiology and Biochemistry Diagnosis Gastric cancer MiRNA Microarray Biomarker |
| title | Altered MiRNA Expression in Gastric Cancer: a Systematic Review and Meta-Analysis |
| title_full | Altered MiRNA Expression in Gastric Cancer: a Systematic Review and Meta-Analysis |
| title_fullStr | Altered MiRNA Expression in Gastric Cancer: a Systematic Review and Meta-Analysis |
| title_full_unstemmed | Altered MiRNA Expression in Gastric Cancer: a Systematic Review and Meta-Analysis |
| title_short | Altered MiRNA Expression in Gastric Cancer: a Systematic Review and Meta-Analysis |
| title_sort | altered mirna expression in gastric cancer a systematic review and meta analysis |
| topic | Diagnosis Gastric cancer MiRNA Microarray Biomarker |
| url | http://www.karger.com/Article/FullText/369750 |
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