RUNX2 prompts triple negative breast cancer drug resistance through TGF-β pathway regulating breast cancer stem cells

RUNX2 prompts triple negative breast cancer drug resistance through TGF-β pathway regulating breast cancer stem cells

Triple-negative breast cancer (TNBC) stands out as the most aggressive subtype within the spectrum of breast cancer. The current clinical guidelines propose treatment strategies involving cytotoxic agents like epirubicin or paclitaxel. However, the emergence of acquired resistance frequently precipi...

Full beskrivning

Bibliografiska uppgifter
Huvudupphovsmän:	Fengxu Lv, Wentao Si, Xiaodan Xu, Xiaogang He, Ying Wang, Yetian Li, Feifei Li
Materialtyp:	Artikel
Språk:	English
Publicerad:	Elsevier 2024-02-01
Serie:	Neoplasia: An International Journal for Oncology Research
Ämnen:	Triple negative breast cancer Chemoresistance Cancer stem cells RUNX2 TGF-β
Länkar:	http://www.sciencedirect.com/science/article/pii/S1476558624000046

Liknande verk

RUNX2 facilitates aggressiveness and chemoresistance of triple negative breast cancer cells via activating MMP1
av: Wentao Si, et al.
Publicerad: (2022-11-01)

RUNX1 Is Regulated by Androgen Receptor to Promote Cancer Stem Markers and Chemotherapy Resistance in Triple Negative Breast Cancer
av: Natalia B. Fernández, et al.
Publicerad: (2023-01-01)

Profiling molecular regulators of recurrence in chemorefractory triple-negative breast cancers
av: Bradley A. Hancock, et al.
Publicerad: (2019-08-01)

Comprehensive Analysis of RUNX and TGF-β Mediated Regulation of Immune Cell Infiltration in Breast Cancer
av: Liang Gao, et al.
Publicerad: (2021-08-01)

TGF-β induced reprogramming and drug resistance in triple-negative breast cells
av: Guoyu Wu, et al.
Publicerad: (2022-04-01)

CIB1 depletion with docetaxel or TRAIL enhances triple-negative breast cancer cell death
av: Alexander H. Chung, et al.
Publicerad: (2019-02-01)

DNA methylation affects metastasis of renal cancer and is associated with TGF-β/RUNX3 inhibition
av: Jianbo Zheng, et al.
Publicerad: (2018-04-01)

Atractylenolide-I Sensitizes Triple-Negative Breast Cancer Cells to Paclitaxel by Blocking CTGF Expression and Fibroblast Activation
av: Meng Wang, et al.
Publicerad: (2021-10-01)

Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers
av: Anuradha Illendula, et al.
Publicerad: (2016-06-01)

Drug resistance profiling of a new triple negative breast cancer patient-derived xenograft model
av: Margarite D. Matossian, et al.
Publicerad: (2019-03-01)

Data mining analysis of miR-638 and key genes interaction in cisplatin resistant triple-negative breast cancer
av: Adam Hermawan, et al.
Publicerad: (2019-12-01)

The RUNX/CBFβ Complex in Breast Cancer: A Conundrum of Context
av: Adiba S. Khan, et al.
Publicerad: (2023-02-01)

Doxorubicin-polyglycerol-nanodiamond conjugate is a cytostatic agent that evades chemoresistance and reverses cancer-induced immunosuppression in triple-negative breast cancer
av: Shen-Jun Yuan, et al.
Publicerad: (2019-10-01)

B7-H4 overexpression contributes to poor prognosis and drug-resistance in triple-negative breast cancer
av: Ling Wang, et al.
Publicerad: (2018-07-01)

A review of biological targets and therapeutic approaches in the management of triple-negative breast cancer
av: Hitesh Kumar, et al.
Publicerad: (2023-12-01)

miR-613 Suppresses Chemoresistance and Stemness in Triple-Negative Breast Cancer by Targeting FAM83A
av: Liu C, et al.
Publicerad: (2020-12-01)

A clinicopathologic study of triple negative breast cancer
av: Vandana L Gaopande, et al.
Publicerad: (2015-01-01)

IL-17A Increases Doxorubicin Efficacy in Triple Negative Breast Cancer
av: Nicholas R. Hum, et al.
Publicerad: (2022-07-01)

Clinically Translatable Approaches of Inhibiting TGF-β to Target Cancer Stem Cells in TNBC
av: Andrew Sulaiman, et al.
Publicerad: (2021-10-01)

CXCR2 Small-Molecule Antagonist Combats Chemoresistance and Enhances Immunotherapy in Triple-Negative Breast Cancer
av: Alaa M. Ghallab, et al.
Publicerad: (2022-04-01)

Discovery of a natural small-molecule compound that suppresses tumor EMT, stemness and metastasis by inhibiting TGFβ/BMP signaling in triple-negative breast cancer
av: Lei Di, et al.
Publicerad: (2019-03-01)

TUFT1 promotes metastasis and chemoresistance in triple negative breast cancer through the TUFT1/Rab5/Rac1 pathway
av: Weiguang Liu, et al.
Publicerad: (2019-09-01)

RUNX regulated immune-associated genes predicts prognosis in breast cancer
av: Jingyue Fu, et al.
Publicerad: (2022-08-01)

M6A demethylase ALKBH5 regulates FOXO1 mRNA stability and chemoresistance in triple-negative breast cancer
av: Xi Liu, et al.
Publicerad: (2024-02-01)

CD74-AKT Axis Is a Potential Therapeutic Target in Triple-Negative Breast Cancer
av: Jingchao Wang, et al.
Publicerad: (2024-06-01)

Role of eIF4A1 in triple‐negative breast cancer stem‐like cell‐mediated drug resistance
av: Dayanidhi Raman, et al.
Publicerad: (2022-12-01)

Cyclodextrin Diethyldithiocarbamate Copper II Inclusion Complexes: A Promising Chemotherapeutic Delivery System against Chemoresistant Triple Negative Breast Cancer Cell Lines
av: Ammar Said Suliman, et al.
Publicerad: (2021-01-01)

Kinome-Wide siRNA Screening Identifies Src-Enhanced Resistance of Chemotherapeutic Drugs in Triple-Negative Breast Cancer Cells
av: Yen-Dun Tony Tzeng, et al.
Publicerad: (2018-11-01)

TUFT1 Promotes Triple Negative Breast Cancer Metastasis, Stemness, and Chemoresistance by Up-Regulating the Rac1/β-Catenin Pathway
av: Weiguang Liu, et al.
Publicerad: (2019-07-01)

Current approaches in treatment of triple-negative breast cancer
av: Hanan Ahmed Wahba, et al.
Publicerad: (2015-06-01)

Triple-Negative Breast Cancer Survival in Iranian Patients
av: Mahdi Aghili, et al.
Publicerad: (2013-08-01)

Platinum chemotherapy for early triple-negative breast cancer
av: Sofia RE. Mason, et al.
Publicerad: (2024-06-01)

Does triple negative breast cancer subtype carry poorer prognosis as compared to non-triple negative breast cancer lesion - A study from a tertiary hospital
av: Srijan Basu, et al.
Publicerad: (2023-11-01)

Is breast conservation superior to mastectomy in early stage triple negative breast cancer?
av: Omran Saifi, et al.
Publicerad: (2022-04-01)

USP7 Induces Chemoresistance in Triple-Negative Breast Cancer via Deubiquitination and Stabilization of ABCB1
av: Yueh-Te Lin, et al.
Publicerad: (2022-10-01)

Immunotherapy Treatment for Triple Negative Breast Cancer
av: Elizabeth R. Berger, et al.
Publicerad: (2021-08-01)

Immunohistochemical evaluation of osteopontin expression in triple-negative breast cancer
av: Magdalena Niedolistek, et al.
Publicerad: (2020-04-01)

Tissue Inhibitor of Metalloproteinases-1 Overexpression Mediates Chemoresistance in Triple-Negative Breast Cancer Cells
av: Lisa Agnello, et al.
Publicerad: (2023-07-01)

Metastatic Triple Negative Breast Cancer: The New Era of Thinking
av: Mohammed Amrallah A., et al.
Publicerad: (2021-05-01)

The Adipokine Visfatin Modulates Cancer Stem Cell Properties in Triple-Negative Breast Cancer
av: Yi-Fen Chiang, et al.
Publicerad: (2023-01-01)