Biomaterials, Current Strategies, and Novel Nano-Technological Approaches for Periodontal Regeneration
Periodontal diseases involve injuries to the supporting structures of the tooth and, if left untreated, can lead to the loss of the tooth. Regenerative periodontal therapies aim, ideally, at healing all the damaged periodontal tissues and represent a significant clinical and societal challenge for t...
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Format: | Article |
Language: | English |
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MDPI AG
2019-01-01
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Series: | Journal of Functional Biomaterials |
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Online Access: | http://www.mdpi.com/2079-4983/10/1/3 |
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author | Giorgio Iviglia Saeid Kargozar Francesco Baino |
author_facet | Giorgio Iviglia Saeid Kargozar Francesco Baino |
author_sort | Giorgio Iviglia |
collection | DOAJ |
description | Periodontal diseases involve injuries to the supporting structures of the tooth and, if left untreated, can lead to the loss of the tooth. Regenerative periodontal therapies aim, ideally, at healing all the damaged periodontal tissues and represent a significant clinical and societal challenge for the current ageing population. This review provides a picture of the currently-used biomaterials for periodontal regeneration, including natural and synthetic polymers, bioceramics (e.g., calcium phosphates and bioactive glasses), and composites. Bioactive materials aim at promoting the regeneration of new healthy tissue. Polymers are often used as barrier materials in guided tissue regeneration strategies and are suitable both to exclude epithelial down-growth and to allow periodontal ligament and alveolar bone cells to repopulate the defect. The problems related to the barrier postoperative collapse can be solved by using a combination of polymeric membranes and grafting materials. Advantages and drawbacks associated with the incorporation of growth factors and nanomaterials in periodontal scaffolds are also discussed, along with the development of multifunctional and multilayer implants. Tissue-engineering strategies based on functionally-graded scaffolds are expected to play an ever-increasing role in the management of periodontal defects. |
first_indexed | 2024-04-11T11:12:14Z |
format | Article |
id | doaj.art-d078ce7ba5424e0e9154754ffe0891bf |
institution | Directory Open Access Journal |
issn | 2079-4983 |
language | English |
last_indexed | 2024-04-11T11:12:14Z |
publishDate | 2019-01-01 |
publisher | MDPI AG |
record_format | Article |
series | Journal of Functional Biomaterials |
spelling | doaj.art-d078ce7ba5424e0e9154754ffe0891bf2022-12-22T04:27:26ZengMDPI AGJournal of Functional Biomaterials2079-49832019-01-01101310.3390/jfb10010003jfb10010003Biomaterials, Current Strategies, and Novel Nano-Technological Approaches for Periodontal RegenerationGiorgio Iviglia0Saeid Kargozar1Francesco Baino2Nobil Bio Ricerche Srl, 14037 Portacomaro d’Asti, ItalyDepartment of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad 917794-8564, IranInstitute of Materials Physics and Engineering, Department of Applied Science and Technology, Politecnico di Torino, 10129 Torino, ItalyPeriodontal diseases involve injuries to the supporting structures of the tooth and, if left untreated, can lead to the loss of the tooth. Regenerative periodontal therapies aim, ideally, at healing all the damaged periodontal tissues and represent a significant clinical and societal challenge for the current ageing population. This review provides a picture of the currently-used biomaterials for periodontal regeneration, including natural and synthetic polymers, bioceramics (e.g., calcium phosphates and bioactive glasses), and composites. Bioactive materials aim at promoting the regeneration of new healthy tissue. Polymers are often used as barrier materials in guided tissue regeneration strategies and are suitable both to exclude epithelial down-growth and to allow periodontal ligament and alveolar bone cells to repopulate the defect. The problems related to the barrier postoperative collapse can be solved by using a combination of polymeric membranes and grafting materials. Advantages and drawbacks associated with the incorporation of growth factors and nanomaterials in periodontal scaffolds are also discussed, along with the development of multifunctional and multilayer implants. Tissue-engineering strategies based on functionally-graded scaffolds are expected to play an ever-increasing role in the management of periodontal defects.http://www.mdpi.com/2079-4983/10/1/3dental materialsperiodontal tissue engineeringdental implantsbioceramicspolymerscompositesbioactivitynanotechnologynanomaterials |
spellingShingle | Giorgio Iviglia Saeid Kargozar Francesco Baino Biomaterials, Current Strategies, and Novel Nano-Technological Approaches for Periodontal Regeneration Journal of Functional Biomaterials dental materials periodontal tissue engineering dental implants bioceramics polymers composites bioactivity nanotechnology nanomaterials |
title | Biomaterials, Current Strategies, and Novel Nano-Technological Approaches for Periodontal Regeneration |
title_full | Biomaterials, Current Strategies, and Novel Nano-Technological Approaches for Periodontal Regeneration |
title_fullStr | Biomaterials, Current Strategies, and Novel Nano-Technological Approaches for Periodontal Regeneration |
title_full_unstemmed | Biomaterials, Current Strategies, and Novel Nano-Technological Approaches for Periodontal Regeneration |
title_short | Biomaterials, Current Strategies, and Novel Nano-Technological Approaches for Periodontal Regeneration |
title_sort | biomaterials current strategies and novel nano technological approaches for periodontal regeneration |
topic | dental materials periodontal tissue engineering dental implants bioceramics polymers composites bioactivity nanotechnology nanomaterials |
url | http://www.mdpi.com/2079-4983/10/1/3 |
work_keys_str_mv | AT giorgioiviglia biomaterialscurrentstrategiesandnovelnanotechnologicalapproachesforperiodontalregeneration AT saeidkargozar biomaterialscurrentstrategiesandnovelnanotechnologicalapproachesforperiodontalregeneration AT francescobaino biomaterialscurrentstrategiesandnovelnanotechnologicalapproachesforperiodontalregeneration |