Functionalized Self-Assembled Monolayers: Versatile Strategies to Combat Bacterial Biofilm Formation
Bacterial infections due to biofilms account for up to 80% of bacterial infections in humans. With the increased use of antibiotic treatments, indwelling medical devices, disinfectants, and longer hospital stays, antibiotic resistant infections are sharply increasing. Annual deaths are predicted to...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/14/8/1613 |
| _version_ | 1797408400360865792 |
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| author | Pamela M. Lundin Briana L. Fiser Meghan S. Blackledge Hannah L. Pickett Abigail L. Copeland |
| author_facet | Pamela M. Lundin Briana L. Fiser Meghan S. Blackledge Hannah L. Pickett Abigail L. Copeland |
| author_sort | Pamela M. Lundin |
| collection | DOAJ |
| description | Bacterial infections due to biofilms account for up to 80% of bacterial infections in humans. With the increased use of antibiotic treatments, indwelling medical devices, disinfectants, and longer hospital stays, antibiotic resistant infections are sharply increasing. Annual deaths are predicted to outpace cancer and diabetes combined by 2050. In the past two decades, both chemical and physical strategies have arisen to combat biofilm formation on surfaces. One such promising chemical strategy is the formation of a self-assembled monolayer (SAM), due to its small layer thickness, strong covalent bonds, typically facile synthesis, and versatility. With the goal of combating biofilm formation, the SAM could be used to tether an antibacterial agent such as a small-molecule antibiotic, nanoparticle, peptide, or polymer to the surface, and limit the agent’s release into its environment. This review focuses on the use of SAMs to inhibit biofilm formation, both on their own and by covalent grafting of a biocidal agent, with the potential to be used in indwelling medical devices. We conclude with our perspectives on ongoing challenges and future directions for this field. |
| first_indexed | 2024-03-09T03:58:53Z |
| format | Article |
| id | doaj.art-d0792ec2ce16459ca44cac25726b622b |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T03:58:53Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-d0792ec2ce16459ca44cac25726b622b2023-12-03T14:17:16ZengMDPI AGPharmaceutics1999-49232022-08-01148161310.3390/pharmaceutics14081613Functionalized Self-Assembled Monolayers: Versatile Strategies to Combat Bacterial Biofilm FormationPamela M. Lundin0Briana L. Fiser1Meghan S. Blackledge2Hannah L. Pickett3Abigail L. Copeland4Department of Chemistry, High Point University, High Point, NC 27268, USADepartment of Physics, High Point University, High Point, NC 27268, USADepartment of Chemistry, High Point University, High Point, NC 27268, USADepartment of Biology, High Point University, High Point, NC 27268, USADepartment of Biology, High Point University, High Point, NC 27268, USABacterial infections due to biofilms account for up to 80% of bacterial infections in humans. With the increased use of antibiotic treatments, indwelling medical devices, disinfectants, and longer hospital stays, antibiotic resistant infections are sharply increasing. Annual deaths are predicted to outpace cancer and diabetes combined by 2050. In the past two decades, both chemical and physical strategies have arisen to combat biofilm formation on surfaces. One such promising chemical strategy is the formation of a self-assembled monolayer (SAM), due to its small layer thickness, strong covalent bonds, typically facile synthesis, and versatility. With the goal of combating biofilm formation, the SAM could be used to tether an antibacterial agent such as a small-molecule antibiotic, nanoparticle, peptide, or polymer to the surface, and limit the agent’s release into its environment. This review focuses on the use of SAMs to inhibit biofilm formation, both on their own and by covalent grafting of a biocidal agent, with the potential to be used in indwelling medical devices. We conclude with our perspectives on ongoing challenges and future directions for this field.https://www.mdpi.com/1999-4923/14/8/1613biofilmsantimicrobialbactericidalindwelling medical devicesself-assembled monolayerssurface modification |
| spellingShingle | Pamela M. Lundin Briana L. Fiser Meghan S. Blackledge Hannah L. Pickett Abigail L. Copeland Functionalized Self-Assembled Monolayers: Versatile Strategies to Combat Bacterial Biofilm Formation Pharmaceutics biofilms antimicrobial bactericidal indwelling medical devices self-assembled monolayers surface modification |
| title | Functionalized Self-Assembled Monolayers: Versatile Strategies to Combat Bacterial Biofilm Formation |
| title_full | Functionalized Self-Assembled Monolayers: Versatile Strategies to Combat Bacterial Biofilm Formation |
| title_fullStr | Functionalized Self-Assembled Monolayers: Versatile Strategies to Combat Bacterial Biofilm Formation |
| title_full_unstemmed | Functionalized Self-Assembled Monolayers: Versatile Strategies to Combat Bacterial Biofilm Formation |
| title_short | Functionalized Self-Assembled Monolayers: Versatile Strategies to Combat Bacterial Biofilm Formation |
| title_sort | functionalized self assembled monolayers versatile strategies to combat bacterial biofilm formation |
| topic | biofilms antimicrobial bactericidal indwelling medical devices self-assembled monolayers surface modification |
| url | https://www.mdpi.com/1999-4923/14/8/1613 |
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