Non-linear association of birth weight with lung function and risk of asthma: A population-based study
BackgroundThe impact of birth weight on lung function and risk of asthma remains contentious. Our aim was to investigate the specific association of birth weight with lung function and the risk of asthma in children.MethodsWe performed cross-sectional analyses of 3,295 children aged 6–15 years who p...
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| Format: | Article |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.999602/full |
| _version_ | 1811215078539657216 |
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| author | Meng Yang Hong Mei Juan Du Linling Yu Liqin Hu Han Xiao |
| author_facet | Meng Yang Hong Mei Juan Du Linling Yu Liqin Hu Han Xiao |
| author_sort | Meng Yang |
| collection | DOAJ |
| description | BackgroundThe impact of birth weight on lung function and risk of asthma remains contentious. Our aim was to investigate the specific association of birth weight with lung function and the risk of asthma in children.MethodsWe performed cross-sectional analyses of 3,295 children aged 6–15 years who participated in the 2007–2012 National Health and Nutrition Examination Survey (NHANES). After controlling for potential covariates other than gestational diabetes, maternal asthma and obesity, the linear and non-linear associations of birth weight with lung function metrics and the risk of asthma were evaluated by a generalized linear model and generalized additive model, respectively.ResultsWe observed a non-linear association of birth weight with FEV1 %predicted, FEV1/FVC %predicted and FEF25 − 75 %predicted (P for non-linearity was 0.0069, 0.0057, and 0.0027, respectively). Further threshold effect analysis of birth weight on lung function detected the turning point for birth weight was 3.6 kg. When the birth weight was < 3.6 kg, birth weight was significantly positively associated with all pulmonary function metrics. However, negative associations were found in FEV1 %predicted, FEV1/FVC %predicted and FEF25 − 75 %predicted when the birth weight was ≥3.6 kg. These results were consistent in the stratified and sensitivity analyses. Additionally, a possible non-linear relationship was also detected between birth weight and the risk of asthma.ConclusionAlthough not all maternal factors were accounted for, our findings provided new insight into the association of birth weight with lung function. Future studies are warranted to confirm the present findings and understand the clinical significance. |
| first_indexed | 2024-04-12T06:15:20Z |
| format | Article |
| id | doaj.art-d07cbad1a8984bb1a570ff6266150898 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-12T06:15:20Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-d07cbad1a8984bb1a570ff62661508982022-12-22T03:44:30ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-11-011010.3389/fpubh.2022.999602999602Non-linear association of birth weight with lung function and risk of asthma: A population-based studyMeng Yang0Hong Mei1Juan Du2Linling Yu3Liqin Hu4Han Xiao5Institute of Maternal and Child Health, Wuhan Maternal and Child Health Care Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Maternal and Child Health, Wuhan Maternal and Child Health Care Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Maternal and Child Health, Wuhan Maternal and Child Health Care Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Maternal and Child Health, Wuhan Maternal and Child Health Care Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Maternal and Child Health, Wuhan Maternal and Child Health Care Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaBackgroundThe impact of birth weight on lung function and risk of asthma remains contentious. Our aim was to investigate the specific association of birth weight with lung function and the risk of asthma in children.MethodsWe performed cross-sectional analyses of 3,295 children aged 6–15 years who participated in the 2007–2012 National Health and Nutrition Examination Survey (NHANES). After controlling for potential covariates other than gestational diabetes, maternal asthma and obesity, the linear and non-linear associations of birth weight with lung function metrics and the risk of asthma were evaluated by a generalized linear model and generalized additive model, respectively.ResultsWe observed a non-linear association of birth weight with FEV1 %predicted, FEV1/FVC %predicted and FEF25 − 75 %predicted (P for non-linearity was 0.0069, 0.0057, and 0.0027, respectively). Further threshold effect analysis of birth weight on lung function detected the turning point for birth weight was 3.6 kg. When the birth weight was < 3.6 kg, birth weight was significantly positively associated with all pulmonary function metrics. However, negative associations were found in FEV1 %predicted, FEV1/FVC %predicted and FEF25 − 75 %predicted when the birth weight was ≥3.6 kg. These results were consistent in the stratified and sensitivity analyses. Additionally, a possible non-linear relationship was also detected between birth weight and the risk of asthma.ConclusionAlthough not all maternal factors were accounted for, our findings provided new insight into the association of birth weight with lung function. Future studies are warranted to confirm the present findings and understand the clinical significance.https://www.frontiersin.org/articles/10.3389/fpubh.2022.999602/fulllung functionasthmathreshold effectbirth weightpublic health |
| spellingShingle | Meng Yang Hong Mei Juan Du Linling Yu Liqin Hu Han Xiao Non-linear association of birth weight with lung function and risk of asthma: A population-based study Frontiers in Public Health lung function asthma threshold effect birth weight public health |
| title | Non-linear association of birth weight with lung function and risk of asthma: A population-based study |
| title_full | Non-linear association of birth weight with lung function and risk of asthma: A population-based study |
| title_fullStr | Non-linear association of birth weight with lung function and risk of asthma: A population-based study |
| title_full_unstemmed | Non-linear association of birth weight with lung function and risk of asthma: A population-based study |
| title_short | Non-linear association of birth weight with lung function and risk of asthma: A population-based study |
| title_sort | non linear association of birth weight with lung function and risk of asthma a population based study |
| topic | lung function asthma threshold effect birth weight public health |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.999602/full |
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