Site-selective C-H hydroxylation of pentacyclic triterpenoids directed by transient chiral pyridine-imino groups
Pentacyclic triterpenoids (PTs) functionalized at the D/E rings possess a wide spectrum of biological activities but are poorly accessible. Here, the authors report a site-selective C-H hydroxylation at the D/E rings of PTs by exploiting transient pyridine-imino directing groups and disclose the syn...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18138-9 |
| _version_ | 1818852691716079616 |
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| author | Tong Mu Bingcheng Wei Dapeng Zhu Biao Yu |
| author_facet | Tong Mu Bingcheng Wei Dapeng Zhu Biao Yu |
| author_sort | Tong Mu |
| collection | DOAJ |
| description | Pentacyclic triterpenoids (PTs) functionalized at the D/E rings possess a wide spectrum of biological activities but are poorly accessible. Here, the authors report a site-selective C-H hydroxylation at the D/E rings of PTs by exploiting transient pyridine-imino directing groups and disclose the synthesis of related natural products. |
| first_indexed | 2024-12-19T07:24:57Z |
| format | Article |
| id | doaj.art-d07d846c1edc4ef99870d29e0afea441 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T07:24:57Z |
| publishDate | 2020-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d07d846c1edc4ef99870d29e0afea4412022-12-21T20:30:52ZengNature PortfolioNature Communications2041-17232020-09-011111810.1038/s41467-020-18138-9Site-selective C-H hydroxylation of pentacyclic triterpenoids directed by transient chiral pyridine-imino groupsTong Mu0Bingcheng Wei1Dapeng Zhu2Biao Yu3State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of SciencesState Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of SciencesState Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of SciencesState Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of SciencesPentacyclic triterpenoids (PTs) functionalized at the D/E rings possess a wide spectrum of biological activities but are poorly accessible. Here, the authors report a site-selective C-H hydroxylation at the D/E rings of PTs by exploiting transient pyridine-imino directing groups and disclose the synthesis of related natural products.https://doi.org/10.1038/s41467-020-18138-9 |
| spellingShingle | Tong Mu Bingcheng Wei Dapeng Zhu Biao Yu Site-selective C-H hydroxylation of pentacyclic triterpenoids directed by transient chiral pyridine-imino groups Nature Communications |
| title | Site-selective C-H hydroxylation of pentacyclic triterpenoids directed by transient chiral pyridine-imino groups |
| title_full | Site-selective C-H hydroxylation of pentacyclic triterpenoids directed by transient chiral pyridine-imino groups |
| title_fullStr | Site-selective C-H hydroxylation of pentacyclic triterpenoids directed by transient chiral pyridine-imino groups |
| title_full_unstemmed | Site-selective C-H hydroxylation of pentacyclic triterpenoids directed by transient chiral pyridine-imino groups |
| title_short | Site-selective C-H hydroxylation of pentacyclic triterpenoids directed by transient chiral pyridine-imino groups |
| title_sort | site selective c h hydroxylation of pentacyclic triterpenoids directed by transient chiral pyridine imino groups |
| url | https://doi.org/10.1038/s41467-020-18138-9 |
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