Insulin‐Like Growth Factor 1 Receptor Deficiency Alleviates Angiotensin II–Induced Cardiac Fibrosis Through the Protein Kinase B/Extracellular Signal‐Regulated Kinase/Nuclear Factor‐κB Pathway

Insulin‐Like Growth Factor 1 Receptor Deficiency Alleviates Angiotensin II–Induced Cardiac Fibrosis Through the Protein Kinase B/Extracellular Signal‐Regulated Kinase/Nuclear Factor‐κB Pathway

Background The renin‐angiotensin system plays a crucial role in the development of heart failure, and Ang II (angiotensin II) acts as the critical effector of the renin‐angiotensin system in regulating cardiac fibrosis. However, the mechanisms of cardiac fibrosis are complex and still not fully unde...

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Bibliographic Details
Main Authors: Jiafeng Zhu, Qian Li, Yan Sun, Shiyu Zhang, Ruiyan Pan, Yanguang Xie, Jinyan Chen, Lihong Shi, Yanbo Chen, Zhipeng Sun, Lane Zhang
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
angiotensin II
cardiac fibrosis
G‐protein–coupled receptor kinase 5
insulin‐like growth factor 1 receptor
protein kinase B/extracellular signal‐regulated kinase/nuclear factor‐κB pathway
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.123.029631

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https://www.ahajournals.org/doi/10.1161/JAHA.123.029631

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