M6A-mediated upregulation of circMDK promotes tumorigenesis and acts as a nanotherapeutic target in hepatocellular carcinoma

M6A-mediated upregulation of circMDK promotes tumorigenesis and acts as a nanotherapeutic target in hepatocellular carcinoma

Abstract Background Emerging evidence suggest the critical role of circular RNAs (circRNAs) in disease development especially in various cancers. However, the oncogenic role of circRNAs in hepatocellular carcinoma (HCC) is still largely unknown. Methods RNA sequencing was performed to identify signi...

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Bibliographic Details
Main Authors: Ashuai Du, Shiqin Li, Yuzheng Zhou, Cyrollah Disoma, Yujie Liao, Yongxing Zhang, Zongpeng Chen, Qinglong Yang, Pinjia Liu, Sixu Liu, Zijun Dong, Aroona Razzaq, Siyi Tao, Xuan Chen, Yuxin Liu, Lunan Xu, Qianjun Zhang, Shanni Li, Jian Peng, Zanxian Xia
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Molecular Cancer
Subjects:
Hepatocellular carcinoma (HCC)
circRNA
N6-methyladenosine (m6A)
IGF2BP1
ATG16L1
Apoptosis
Online Access:https://doi.org/10.1186/s12943-022-01575-z

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