Near‐infrared light‐responsive Nitric oxide microcarrier for multimodal tumor therapy
Abstract Nitric oxide (NO) has shown great potential in tumor therapy, and the development of a platform for precise and controllable NO release still needs to be explored. Herein, a microfluidic electrospray strategy is proposed for the fabrication of hydrogel microspheres encapsulating NO donors (...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2023-08-01
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| Series: | Smart Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/SMMD.20230016 |
| _version_ | 1827856667885174784 |
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| author | Danna Liang Gaizhen Kuang Xiang Chen Jianhua Lu Luoran Shang Weijian Sun |
| author_facet | Danna Liang Gaizhen Kuang Xiang Chen Jianhua Lu Luoran Shang Weijian Sun |
| author_sort | Danna Liang |
| collection | DOAJ |
| description | Abstract Nitric oxide (NO) has shown great potential in tumor therapy, and the development of a platform for precise and controllable NO release still needs to be explored. Herein, a microfluidic electrospray strategy is proposed for the fabrication of hydrogel microspheres encapsulating NO donors (S‐nitrosoglutathione, GSNO) together with black phosphorus (BP) and chemotherapeutic doxorubicin (DOX) as microcarriers for tumor therapy. Based on the excellent photothermal property of BP and thermal sensitivity of GSNO, the microcarriers exhibit a near‐infrared light (NIR)‐responsive NO release behavior. Besides, the photothermal performance of the microcarriers accelerates the release of DOX. All these contribute to the excellent tumor‐killing effect of the microcarriers by combining multiple therapeutic strategies including NO therapy, photothermal therapy, and chemotherapy. Moreover, it was demonstrated that the NIR‐responsive NO delivery microcarriers could significantly inhibit tumor growth without apparent side effects in vivo. Therefore, it is believed that the novel NIR‐responsive NO microcarriers are promising candidates in clinical tumor therapy applications. |
| first_indexed | 2024-03-12T12:29:06Z |
| format | Article |
| id | doaj.art-d08016c654464fccb37d0e833b69b695 |
| institution | Directory Open Access Journal |
| issn | 2751-1871 |
| language | English |
| last_indexed | 2024-03-12T12:29:06Z |
| publishDate | 2023-08-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Smart Medicine |
| spelling | doaj.art-d08016c654464fccb37d0e833b69b6952023-08-29T17:51:25ZengWiley-VCHSmart Medicine2751-18712023-08-0123n/an/a10.1002/SMMD.20230016Near‐infrared light‐responsive Nitric oxide microcarrier for multimodal tumor therapyDanna Liang0Gaizhen Kuang1Xiang Chen2Jianhua Lu3Luoran Shang4Weijian Sun5Department of Gastrointestinal Surgery The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou Zhejiang ChinaOujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health) Wenzhou Institute University of Chinese Academy of Sciences Wenzhou Zhejiang ChinaDepartment of Gastrointestinal Surgery The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou Zhejiang ChinaDepartment of Gastrointestinal Surgery The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou Zhejiang ChinaDepartment of Gastrointestinal Surgery The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou Zhejiang ChinaDepartment of Gastrointestinal Surgery The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou Zhejiang ChinaAbstract Nitric oxide (NO) has shown great potential in tumor therapy, and the development of a platform for precise and controllable NO release still needs to be explored. Herein, a microfluidic electrospray strategy is proposed for the fabrication of hydrogel microspheres encapsulating NO donors (S‐nitrosoglutathione, GSNO) together with black phosphorus (BP) and chemotherapeutic doxorubicin (DOX) as microcarriers for tumor therapy. Based on the excellent photothermal property of BP and thermal sensitivity of GSNO, the microcarriers exhibit a near‐infrared light (NIR)‐responsive NO release behavior. Besides, the photothermal performance of the microcarriers accelerates the release of DOX. All these contribute to the excellent tumor‐killing effect of the microcarriers by combining multiple therapeutic strategies including NO therapy, photothermal therapy, and chemotherapy. Moreover, it was demonstrated that the NIR‐responsive NO delivery microcarriers could significantly inhibit tumor growth without apparent side effects in vivo. Therefore, it is believed that the novel NIR‐responsive NO microcarriers are promising candidates in clinical tumor therapy applications.https://doi.org/10.1002/SMMD.20230016gas therapymicrocarriersmicrofluidic electrospraymultimodal tumor therapynitric oxide |
| spellingShingle | Danna Liang Gaizhen Kuang Xiang Chen Jianhua Lu Luoran Shang Weijian Sun Near‐infrared light‐responsive Nitric oxide microcarrier for multimodal tumor therapy Smart Medicine gas therapy microcarriers microfluidic electrospray multimodal tumor therapy nitric oxide |
| title | Near‐infrared light‐responsive Nitric oxide microcarrier for multimodal tumor therapy |
| title_full | Near‐infrared light‐responsive Nitric oxide microcarrier for multimodal tumor therapy |
| title_fullStr | Near‐infrared light‐responsive Nitric oxide microcarrier for multimodal tumor therapy |
| title_full_unstemmed | Near‐infrared light‐responsive Nitric oxide microcarrier for multimodal tumor therapy |
| title_short | Near‐infrared light‐responsive Nitric oxide microcarrier for multimodal tumor therapy |
| title_sort | near infrared light responsive nitric oxide microcarrier for multimodal tumor therapy |
| topic | gas therapy microcarriers microfluidic electrospray multimodal tumor therapy nitric oxide |
| url | https://doi.org/10.1002/SMMD.20230016 |
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