Pembrolizumab related Guillain barre syndrome, a rare presentation in a patient with a history of lupus and bladder cancer
Immune checkpoint inhibitor-related neurotoxicity causing Guillain Barre Syndrome is relatively uncommon. We discussed an 80-year-old patient with known systemic lupus erythematosus who presented with lower extremity weakness, areflexia and then progressed to respiratory muscle and upper extremity w...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Greater Baltimore Medical Center
2021-05-01
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| Series: | Journal of Community Hospital Internal Medicine Perspectives |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/20009666.2021.1903133 |
| _version_ | 1797970677135835136 |
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| author | Vikram Sangani Mytri Pokal Mamtha Balla Ganesh Prasad Merugu Sreedhar Adapa Srikanth Naramala Venu Madhav Konala |
| author_facet | Vikram Sangani Mytri Pokal Mamtha Balla Ganesh Prasad Merugu Sreedhar Adapa Srikanth Naramala Venu Madhav Konala |
| author_sort | Vikram Sangani |
| collection | DOAJ |
| description | Immune checkpoint inhibitor-related neurotoxicity causing Guillain Barre Syndrome is relatively uncommon. We discussed an 80-year-old patient with known systemic lupus erythematosus who presented with lower extremity weakness, areflexia and then progressed to respiratory muscle and upper extremity weakness after receiving immunotherapy with checkpoint inhibitors for metastatic bladder cancer. With the increasing use of immunotherapy for the management of cancer, awareness of neurological autoimmune side effects is essential. Immune checkpoint inhibitor-mediated GBS can be severe and fatal if not diagnosed promptly. The hospitalists, neurologists, and oncologists should be aware of neurotoxicity related to immune checkpoint inhibitor therapy requiring a multidisciplinary approach to patient care. Prompt initiation of immunosuppressive therapy is required for the management of immune checkpoint inhibitor-related neurotoxicity. |
| first_indexed | 2024-04-11T03:20:50Z |
| format | Article |
| id | doaj.art-d080f93bd3be45199281b0883e2c75ff |
| institution | Directory Open Access Journal |
| issn | 2000-9666 |
| language | English |
| last_indexed | 2024-04-11T03:20:50Z |
| publishDate | 2021-05-01 |
| publisher | Greater Baltimore Medical Center |
| record_format | Article |
| series | Journal of Community Hospital Internal Medicine Perspectives |
| spelling | doaj.art-d080f93bd3be45199281b0883e2c75ff2023-01-02T09:08:44ZengGreater Baltimore Medical CenterJournal of Community Hospital Internal Medicine Perspectives2000-96662021-05-0111338839210.1080/20009666.2021.19031331903133Pembrolizumab related Guillain barre syndrome, a rare presentation in a patient with a history of lupus and bladder cancerVikram Sangani0Mytri Pokal1Mamtha Balla2Ganesh Prasad Merugu3Sreedhar Adapa4Srikanth Naramala5Venu Madhav Konala6Quantum HCQuantum HCUniversity of Toledo and Promedica Toledo HospitalUniversity of ToledoAdventist Medical CenterAdventist Medical CenterAshland Bellefonte Cancer CenterImmune checkpoint inhibitor-related neurotoxicity causing Guillain Barre Syndrome is relatively uncommon. We discussed an 80-year-old patient with known systemic lupus erythematosus who presented with lower extremity weakness, areflexia and then progressed to respiratory muscle and upper extremity weakness after receiving immunotherapy with checkpoint inhibitors for metastatic bladder cancer. With the increasing use of immunotherapy for the management of cancer, awareness of neurological autoimmune side effects is essential. Immune checkpoint inhibitor-mediated GBS can be severe and fatal if not diagnosed promptly. The hospitalists, neurologists, and oncologists should be aware of neurotoxicity related to immune checkpoint inhibitor therapy requiring a multidisciplinary approach to patient care. Prompt initiation of immunosuppressive therapy is required for the management of immune checkpoint inhibitor-related neurotoxicity.http://dx.doi.org/10.1080/20009666.2021.1903133keytrudapembrolizumabguillain barre syndromeimmune checkpoint inhibitorneurological complicationspd 1 antibody |
| spellingShingle | Vikram Sangani Mytri Pokal Mamtha Balla Ganesh Prasad Merugu Sreedhar Adapa Srikanth Naramala Venu Madhav Konala Pembrolizumab related Guillain barre syndrome, a rare presentation in a patient with a history of lupus and bladder cancer Journal of Community Hospital Internal Medicine Perspectives keytruda pembrolizumab guillain barre syndrome immune checkpoint inhibitor neurological complications pd 1 antibody |
| title | Pembrolizumab related Guillain barre syndrome, a rare presentation in a patient with a history of lupus and bladder cancer |
| title_full | Pembrolizumab related Guillain barre syndrome, a rare presentation in a patient with a history of lupus and bladder cancer |
| title_fullStr | Pembrolizumab related Guillain barre syndrome, a rare presentation in a patient with a history of lupus and bladder cancer |
| title_full_unstemmed | Pembrolizumab related Guillain barre syndrome, a rare presentation in a patient with a history of lupus and bladder cancer |
| title_short | Pembrolizumab related Guillain barre syndrome, a rare presentation in a patient with a history of lupus and bladder cancer |
| title_sort | pembrolizumab related guillain barre syndrome a rare presentation in a patient with a history of lupus and bladder cancer |
| topic | keytruda pembrolizumab guillain barre syndrome immune checkpoint inhibitor neurological complications pd 1 antibody |
| url | http://dx.doi.org/10.1080/20009666.2021.1903133 |
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