Antifibrotic drugs as therapeutic tools in resistant melanoma
Melanoma is the most aggressive form of skin cancer. Together with the recent advances in immunotherapy, targeted therapy with inhibitors of the Mitogen Activated Protein Kinase (MAPKi) pathway including BRAF and MEK inhibitors has greatly improved the clinical outcome of these patients. Unfortunate...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer Nature
2022-03-01
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| Series: | EMBO Molecular Medicine |
| Online Access: | https://doi.org/10.15252/emmm.202115449 |
| _version_ | 1797287659110924288 |
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| author | Berta Sanchez‐Laorden M Angela Nieto |
| author_facet | Berta Sanchez‐Laorden M Angela Nieto |
| author_sort | Berta Sanchez‐Laorden |
| collection | DOAJ |
| description | Melanoma is the most aggressive form of skin cancer. Together with the recent advances in immunotherapy, targeted therapy with inhibitors of the Mitogen Activated Protein Kinase (MAPKi) pathway including BRAF and MEK inhibitors has greatly improved the clinical outcome of these patients. Unfortunately, due to genetic and non‐genetic events, many patients develop resistance to MAPKi. Melanoma phenotypic plasticity, understood as the ability of melanoma cells to dynamically transition between different states with varying levels of differentiation/dedifferentiation, is key for melanoma progression. Lineage plasticity has also emerged as an important mechanism of non‐genetic adaptive melanoma drug resistance in the clinic (Arozarena & Wellbrock, 2019), highlighting the need for a deeper characterization of the mechanisms that control this process. In this issue of EMBO Molecular Medicine, Diazzi et al (2022) identify a mechanism regulating MAPKi‐induced phenotypic plasticity and resistance, providing evidence to support the use of an anti‐fibrotic drug as a potential novel combinatorial therapeutic approach. |
| first_indexed | 2024-03-07T18:37:38Z |
| format | Article |
| id | doaj.art-d0823d698f464087b9286764f10582a2 |
| institution | Directory Open Access Journal |
| issn | 1757-4676 1757-4684 |
| language | English |
| last_indexed | 2024-03-07T18:37:38Z |
| publishDate | 2022-03-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj.art-d0823d698f464087b9286764f10582a22024-03-02T04:52:15ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842022-03-01143n/an/a10.15252/emmm.202115449Antifibrotic drugs as therapeutic tools in resistant melanomaBerta Sanchez‐Laorden0M Angela Nieto1Instituto de Neurociencias (CSIC‐UMH) Sant Joan d’Alacant SpainInstituto de Neurociencias (CSIC‐UMH) Sant Joan d’Alacant SpainMelanoma is the most aggressive form of skin cancer. Together with the recent advances in immunotherapy, targeted therapy with inhibitors of the Mitogen Activated Protein Kinase (MAPKi) pathway including BRAF and MEK inhibitors has greatly improved the clinical outcome of these patients. Unfortunately, due to genetic and non‐genetic events, many patients develop resistance to MAPKi. Melanoma phenotypic plasticity, understood as the ability of melanoma cells to dynamically transition between different states with varying levels of differentiation/dedifferentiation, is key for melanoma progression. Lineage plasticity has also emerged as an important mechanism of non‐genetic adaptive melanoma drug resistance in the clinic (Arozarena & Wellbrock, 2019), highlighting the need for a deeper characterization of the mechanisms that control this process. In this issue of EMBO Molecular Medicine, Diazzi et al (2022) identify a mechanism regulating MAPKi‐induced phenotypic plasticity and resistance, providing evidence to support the use of an anti‐fibrotic drug as a potential novel combinatorial therapeutic approach.https://doi.org/10.15252/emmm.202115449 |
| spellingShingle | Berta Sanchez‐Laorden M Angela Nieto Antifibrotic drugs as therapeutic tools in resistant melanoma EMBO Molecular Medicine |
| title | Antifibrotic drugs as therapeutic tools in resistant melanoma |
| title_full | Antifibrotic drugs as therapeutic tools in resistant melanoma |
| title_fullStr | Antifibrotic drugs as therapeutic tools in resistant melanoma |
| title_full_unstemmed | Antifibrotic drugs as therapeutic tools in resistant melanoma |
| title_short | Antifibrotic drugs as therapeutic tools in resistant melanoma |
| title_sort | antifibrotic drugs as therapeutic tools in resistant melanoma |
| url | https://doi.org/10.15252/emmm.202115449 |
| work_keys_str_mv | AT bertasanchezlaorden antifibroticdrugsastherapeutictoolsinresistantmelanoma AT mangelanieto antifibroticdrugsastherapeutictoolsinresistantmelanoma |