Urinary Arsenic Concentration and Its Relationship with Bronchial Asthma in Children from Arica, Chile
In the city of Arica, northern Chile, the population has been involuntarily exposed to arsenic of natural and anthropogenic origin. This study aims to evaluate the association between urinary arsenic concentration and bronchial asthma diagnosis in the children of Arica. A cross-sectional analysis of...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-10-01
|
| Series: | Toxics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2305-6304/10/10/625 |
| _version_ | 1797469802226253824 |
|---|---|
| author | María Pía Muñoz Verónica Iglesias Marta Saavedra Gina Saavedra Karla Yohannessen Paulina Pino |
| author_facet | María Pía Muñoz Verónica Iglesias Marta Saavedra Gina Saavedra Karla Yohannessen Paulina Pino |
| author_sort | María Pía Muñoz |
| collection | DOAJ |
| description | In the city of Arica, northern Chile, the population has been involuntarily exposed to arsenic of natural and anthropogenic origin. This study aims to evaluate the association between urinary arsenic concentration and bronchial asthma diagnosis in the children of Arica. A cross-sectional analysis of a database of 1892 subjects under 18 years of age enrolled in the Environmental Health Centre between 2009 and 2021 was carried out. Arsenic exposure was obtained from a urine sample and bronchial asthma diagnosis from the database of the system for the management of explicit health guarantees. Logistic regression models were used to assess the association between inorganic arsenic and asthma. The median inorganic arsenic was 15 μg/L, and the prevalence of asthma was 7.4%. After adjusting for sex, age, ethnicity, and urinary creatinine, children with the highest tertile of urinary arsenic concentration (≥21.4 μg/L) had a greater chance of developing asthma (odds ratio (OR) 1.90; 95% confidence interval (CI) [1.13–3.18]). When exploring the modifying effect of ethnicity, the association increased among children belonging to any ethnic group (OR 3.51, 95%CI [1.43–8.65]). These findings suggest a relationship between arsenic exposure and bronchial asthma in children. While further studies are needed to assess the impact of arsenic on respiratory health, mitigation efforts to reduce arsenic exposure should be maintained. |
| first_indexed | 2024-03-09T19:26:16Z |
| format | Article |
| id | doaj.art-d082452575cf4fca86401d7d42cd5c6c |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-09T19:26:16Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-d082452575cf4fca86401d7d42cd5c6c2023-11-24T02:58:15ZengMDPI AGToxics2305-63042022-10-01101062510.3390/toxics10100625Urinary Arsenic Concentration and Its Relationship with Bronchial Asthma in Children from Arica, ChileMaría Pía Muñoz0Verónica Iglesias1Marta Saavedra2Gina Saavedra3Karla Yohannessen4Paulina Pino5Programa Doctorado en Salud Pública, Escuela de Salud Pública, Facultad de Medicina, Universidad de Chile, Independencia 939, Santiago 8380453, ChilePrograma de Epidemiología, Escuela de Salud Pública, Facultad de Medicina, Universidad de Chile, Independencia 939, Santiago 8380453, ChileDepartamento de Salud Pública, Secretaría Regional Ministerial de Salud Arica y Parinacota, Maipú 410, Arica 1000426, ChileDepartamento de Salud Pública, Secretaría Regional Ministerial de Salud Arica y Parinacota, Maipú 410, Arica 1000426, ChilePrograma de Epidemiología, Escuela de Salud Pública, Facultad de Medicina, Universidad de Chile, Independencia 939, Santiago 8380453, ChilePrograma de Epidemiología, Escuela de Salud Pública, Facultad de Medicina, Universidad de Chile, Independencia 939, Santiago 8380453, ChileIn the city of Arica, northern Chile, the population has been involuntarily exposed to arsenic of natural and anthropogenic origin. This study aims to evaluate the association between urinary arsenic concentration and bronchial asthma diagnosis in the children of Arica. A cross-sectional analysis of a database of 1892 subjects under 18 years of age enrolled in the Environmental Health Centre between 2009 and 2021 was carried out. Arsenic exposure was obtained from a urine sample and bronchial asthma diagnosis from the database of the system for the management of explicit health guarantees. Logistic regression models were used to assess the association between inorganic arsenic and asthma. The median inorganic arsenic was 15 μg/L, and the prevalence of asthma was 7.4%. After adjusting for sex, age, ethnicity, and urinary creatinine, children with the highest tertile of urinary arsenic concentration (≥21.4 μg/L) had a greater chance of developing asthma (odds ratio (OR) 1.90; 95% confidence interval (CI) [1.13–3.18]). When exploring the modifying effect of ethnicity, the association increased among children belonging to any ethnic group (OR 3.51, 95%CI [1.43–8.65]). These findings suggest a relationship between arsenic exposure and bronchial asthma in children. While further studies are needed to assess the impact of arsenic on respiratory health, mitigation efforts to reduce arsenic exposure should be maintained.https://www.mdpi.com/2305-6304/10/10/625bronchial asthmachildenvironmental exposureethnicitypopulation surveillanceurinary arsenic |
| spellingShingle | María Pía Muñoz Verónica Iglesias Marta Saavedra Gina Saavedra Karla Yohannessen Paulina Pino Urinary Arsenic Concentration and Its Relationship with Bronchial Asthma in Children from Arica, Chile Toxics bronchial asthma child environmental exposure ethnicity population surveillance urinary arsenic |
| title | Urinary Arsenic Concentration and Its Relationship with Bronchial Asthma in Children from Arica, Chile |
| title_full | Urinary Arsenic Concentration and Its Relationship with Bronchial Asthma in Children from Arica, Chile |
| title_fullStr | Urinary Arsenic Concentration and Its Relationship with Bronchial Asthma in Children from Arica, Chile |
| title_full_unstemmed | Urinary Arsenic Concentration and Its Relationship with Bronchial Asthma in Children from Arica, Chile |
| title_short | Urinary Arsenic Concentration and Its Relationship with Bronchial Asthma in Children from Arica, Chile |
| title_sort | urinary arsenic concentration and its relationship with bronchial asthma in children from arica chile |
| topic | bronchial asthma child environmental exposure ethnicity population surveillance urinary arsenic |
| url | https://www.mdpi.com/2305-6304/10/10/625 |
| work_keys_str_mv | AT mariapiamunoz urinaryarsenicconcentrationanditsrelationshipwithbronchialasthmainchildrenfromaricachile AT veronicaiglesias urinaryarsenicconcentrationanditsrelationshipwithbronchialasthmainchildrenfromaricachile AT martasaavedra urinaryarsenicconcentrationanditsrelationshipwithbronchialasthmainchildrenfromaricachile AT ginasaavedra urinaryarsenicconcentrationanditsrelationshipwithbronchialasthmainchildrenfromaricachile AT karlayohannessen urinaryarsenicconcentrationanditsrelationshipwithbronchialasthmainchildrenfromaricachile AT paulinapino urinaryarsenicconcentrationanditsrelationshipwithbronchialasthmainchildrenfromaricachile |