A Reliable and Simple Method for Fabricating a Poly(Dimethylsiloxane) Electrospray Ionization Chip with a Corner-Integrated Emitter
Monolithically integrated emitters have been increasingly applied to microfluidic devices that are coupled to mass spectrometers (MS) as electrospray ionization sources (ESI). A new method was developed to fabricate a duplicable structure which integrated the emitter into a poly(dimethylsiloxane) ch...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-04-01
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| Series: | Sensors |
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| Online Access: | http://www.mdpi.com/1424-8220/15/4/8931 |
| _version_ | 1797999840834093056 |
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| author | Xiang Qian Jie Xu Cilong Yu Yan Chen Quan Yu Kai Ni Xiaohao Wang |
| author_facet | Xiang Qian Jie Xu Cilong Yu Yan Chen Quan Yu Kai Ni Xiaohao Wang |
| author_sort | Xiang Qian |
| collection | DOAJ |
| description | Monolithically integrated emitters have been increasingly applied to microfluidic devices that are coupled to mass spectrometers (MS) as electrospray ionization sources (ESI). A new method was developed to fabricate a duplicable structure which integrated the emitter into a poly(dimethylsiloxane) chip corner. Two photoresist layers containing a raised base which guaranteed the precise integration of the electrospray tip emitter and ensured that the cutting out of the tip exerted no influence even during repeated prototyping were used to ease the operation of the process. Highly stable ESI-MS performance was obtained and the results were compared with those of a commercial fused-silica capillary source. Furthermore, chip-to-chip and run-to-run results indicated both reliability and reproducibility during repeated fabrication. These results reveal that the proposed chip can provide an ideal ion source for MS across many applications, especially with the perspective to be widely used in portable MS during on-site analysis. |
| first_indexed | 2024-04-11T11:11:09Z |
| format | Article |
| id | doaj.art-d0826c9a09e84a80a07479eaba49a2dc |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-11T11:11:09Z |
| publishDate | 2015-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-d0826c9a09e84a80a07479eaba49a2dc2022-12-22T04:27:28ZengMDPI AGSensors1424-82202015-04-011548931894410.3390/s150408931s150408931A Reliable and Simple Method for Fabricating a Poly(Dimethylsiloxane) Electrospray Ionization Chip with a Corner-Integrated EmitterXiang Qian0Jie Xu1Cilong Yu2Yan Chen3Quan Yu4Kai Ni5Xiaohao Wang6Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, ChinaGraduate School at Shenzhen, Tsinghua University, Shenzhen 518055, ChinaGraduate School at Shenzhen, Tsinghua University, Shenzhen 518055, ChinaShenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaGraduate School at Shenzhen, Tsinghua University, Shenzhen 518055, ChinaGraduate School at Shenzhen, Tsinghua University, Shenzhen 518055, ChinaGraduate School at Shenzhen, Tsinghua University, Shenzhen 518055, ChinaMonolithically integrated emitters have been increasingly applied to microfluidic devices that are coupled to mass spectrometers (MS) as electrospray ionization sources (ESI). A new method was developed to fabricate a duplicable structure which integrated the emitter into a poly(dimethylsiloxane) chip corner. Two photoresist layers containing a raised base which guaranteed the precise integration of the electrospray tip emitter and ensured that the cutting out of the tip exerted no influence even during repeated prototyping were used to ease the operation of the process. Highly stable ESI-MS performance was obtained and the results were compared with those of a commercial fused-silica capillary source. Furthermore, chip-to-chip and run-to-run results indicated both reliability and reproducibility during repeated fabrication. These results reveal that the proposed chip can provide an ideal ion source for MS across many applications, especially with the perspective to be widely used in portable MS during on-site analysis.http://www.mdpi.com/1424-8220/15/4/8931microfluidic chipmulti-layer soft lithographyelectrospray ionization |
| spellingShingle | Xiang Qian Jie Xu Cilong Yu Yan Chen Quan Yu Kai Ni Xiaohao Wang A Reliable and Simple Method for Fabricating a Poly(Dimethylsiloxane) Electrospray Ionization Chip with a Corner-Integrated Emitter Sensors microfluidic chip multi-layer soft lithography electrospray ionization |
| title | A Reliable and Simple Method for Fabricating a Poly(Dimethylsiloxane) Electrospray Ionization Chip with a Corner-Integrated Emitter |
| title_full | A Reliable and Simple Method for Fabricating a Poly(Dimethylsiloxane) Electrospray Ionization Chip with a Corner-Integrated Emitter |
| title_fullStr | A Reliable and Simple Method for Fabricating a Poly(Dimethylsiloxane) Electrospray Ionization Chip with a Corner-Integrated Emitter |
| title_full_unstemmed | A Reliable and Simple Method for Fabricating a Poly(Dimethylsiloxane) Electrospray Ionization Chip with a Corner-Integrated Emitter |
| title_short | A Reliable and Simple Method for Fabricating a Poly(Dimethylsiloxane) Electrospray Ionization Chip with a Corner-Integrated Emitter |
| title_sort | reliable and simple method for fabricating a poly dimethylsiloxane electrospray ionization chip with a corner integrated emitter |
| topic | microfluidic chip multi-layer soft lithography electrospray ionization |
| url | http://www.mdpi.com/1424-8220/15/4/8931 |
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