Ionic Liquids as Potential and Synergistic Permeation Enhancers for Transdermal Drug Delivery
Transdermal drug delivery systems (TDDS) show clear advantages over conventional routes of drug administration. Nonetheless, there are limitations to current TDDS which warrant further research to improve current TDD platforms. Spurred by the synthesis of novel biodegradable ionic liquids (ILs) and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-02-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/11/2/96 |
| _version_ | 1798024370887589888 |
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| author | Zainul Sidat Thashree Marimuthu Pradeep Kumar Lisa C. du Toit Pierre P. D. Kondiah Yahya E. Choonara Viness Pillay |
| author_facet | Zainul Sidat Thashree Marimuthu Pradeep Kumar Lisa C. du Toit Pierre P. D. Kondiah Yahya E. Choonara Viness Pillay |
| author_sort | Zainul Sidat |
| collection | DOAJ |
| description | Transdermal drug delivery systems (TDDS) show clear advantages over conventional routes of drug administration. Nonetheless, there are limitations to current TDDS which warrant further research to improve current TDD platforms. Spurred by the synthesis of novel biodegradable ionic liquids (ILs) and favorable cytotoxicity studies, ILs were shown to be a possible solution to overcome these challenges. Their favorable application in overcoming challenges ranging from synthesis, manufacture, and even therapeutic benefits were documented. In this review, said ILs are highlighted and their role in TDDS is reviewed in terms of (a) ILs as permeation enhancers (single agents or combined), (b) ILs in drug modification, and (c) ILs as active pharmaceutical ingredients. Furthermore, future combination of ILs with other chemical permeation enhancers (CPEs) is proposed and discussed. |
| first_indexed | 2024-04-11T18:01:23Z |
| format | Article |
| id | doaj.art-d0842830b1544879961b6eae73e8c896 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-11T18:01:23Z |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-d0842830b1544879961b6eae73e8c8962022-12-22T04:10:29ZengMDPI AGPharmaceutics1999-49232019-02-011129610.3390/pharmaceutics11020096pharmaceutics11020096Ionic Liquids as Potential and Synergistic Permeation Enhancers for Transdermal Drug DeliveryZainul Sidat0Thashree Marimuthu1Pradeep Kumar2Lisa C. du Toit3Pierre P. D. Kondiah4Yahya E. Choonara5Viness Pillay6Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown 2193, South AfricaWits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown 2193, South AfricaWits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown 2193, South AfricaWits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown 2193, South AfricaWits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown 2193, South AfricaWits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown 2193, South AfricaWits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown 2193, South AfricaTransdermal drug delivery systems (TDDS) show clear advantages over conventional routes of drug administration. Nonetheless, there are limitations to current TDDS which warrant further research to improve current TDD platforms. Spurred by the synthesis of novel biodegradable ionic liquids (ILs) and favorable cytotoxicity studies, ILs were shown to be a possible solution to overcome these challenges. Their favorable application in overcoming challenges ranging from synthesis, manufacture, and even therapeutic benefits were documented. In this review, said ILs are highlighted and their role in TDDS is reviewed in terms of (a) ILs as permeation enhancers (single agents or combined), (b) ILs in drug modification, and (c) ILs as active pharmaceutical ingredients. Furthermore, future combination of ILs with other chemical permeation enhancers (CPEs) is proposed and discussed.https://www.mdpi.com/1999-4923/11/2/96ionic liquidstransdermalsynergypermeation enhancerchemicalphysicalTransdermal drug delivery systems |
| spellingShingle | Zainul Sidat Thashree Marimuthu Pradeep Kumar Lisa C. du Toit Pierre P. D. Kondiah Yahya E. Choonara Viness Pillay Ionic Liquids as Potential and Synergistic Permeation Enhancers for Transdermal Drug Delivery Pharmaceutics ionic liquids transdermal synergy permeation enhancer chemical physical Transdermal drug delivery systems |
| title | Ionic Liquids as Potential and Synergistic Permeation Enhancers for Transdermal Drug Delivery |
| title_full | Ionic Liquids as Potential and Synergistic Permeation Enhancers for Transdermal Drug Delivery |
| title_fullStr | Ionic Liquids as Potential and Synergistic Permeation Enhancers for Transdermal Drug Delivery |
| title_full_unstemmed | Ionic Liquids as Potential and Synergistic Permeation Enhancers for Transdermal Drug Delivery |
| title_short | Ionic Liquids as Potential and Synergistic Permeation Enhancers for Transdermal Drug Delivery |
| title_sort | ionic liquids as potential and synergistic permeation enhancers for transdermal drug delivery |
| topic | ionic liquids transdermal synergy permeation enhancer chemical physical Transdermal drug delivery systems |
| url | https://www.mdpi.com/1999-4923/11/2/96 |
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