Cationic Geminoid Peptide Amphiphiles Inhibit DENV2 Protease, Furin, and Viral Replication

Cationic Geminoid Peptide Amphiphiles Inhibit DENV2 Protease, Furin, and Viral Replication

Dengue is an important arboviral infectious disease for which there is currently no specific cure. We report gemini-like (geminoid) alkylated amphiphilic peptides containing lysines in combination with glycines or alanines (C<sub>15</sub>H<sub>31</sub>C(O)-Lys-(Gly or Ala)<...

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Bibliographic Details
Main Authors: Mark Damen, Mario A. Izidoro, Debora N. Okamoto, Lilian C. G. Oliveira, Helene I. V. Amatdjais-Groenen, Stijn F. M. van Dongen, Koen W. R. van Cleef, Ronald P. van Rij, Cindy E. J. Dieteren, Daniel Gironés, Bernd N. M. van Buuren, Byron E. E. Martina, Albert D. M. E. Osterhaus, Luiz Juliano, Bob J. Scholte, Martin C. Feiters
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Molecules
Subjects:
amphiphiles
drug discovery
inhibitors
membrane proteins
peptides
Online Access:https://www.mdpi.com/1420-3049/27/10/3217

Internet

https://www.mdpi.com/1420-3049/27/10/3217

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