Genetic variation in folate metabolism is associated with the risk of conotruncal heart defects in a Chinese population

Genetic variation in folate metabolism is associated with the risk of conotruncal heart defects in a Chinese population

Abstract Background Conotruncal heart defects (CTDs) are a subgroup of congenital heart defects that are considered to be the most common type of birth defect worldwide. Genetic disturbances in folate metabolism may increase the risk of CTDs. Methods We evaluated five single-nucleotide polymorphisms...

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Bibliographic Details
Main Authors: Xike Wang, Haitao Wei, Ying Tian, Yue Wu, Lei Luo
Format: Article
Language:English
Published: BMC 2018-08-01
Series:BMC Pediatrics
Subjects:
Conotruncal heart defect
Single-nucleotide polymorphism
Methionine synthase
Methylenetetrahydrofolate reductase
Solute carrier family 19
Online Access:http://link.springer.com/article/10.1186/s12887-018-1266-9

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