Effects of Rhythm and Rate-Controlling Drugs in Patients With Permanent His-Bundle Pacing
Introduction: Antiarrhythmic drug therapy can affect pacemaker parameters in both the atrial and ventricular myocardium. It is not known whether antiarrhythmic drugs impact His bundle pacing/sensing parameters and His to ventricle (H-V) intervals following permanent His bundle pacing (HBP). The aims...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-12-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2020.585165/full |
| _version_ | 1818438663598505984 |
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| author | Lan Su Lan Su Xue Xia Xue Xia Dongjie Liang Dongjie Liang Shengjie Wu Shengjie Wu Lei Xu Lei Xu Tiancheng Xu Tiancheng Xu Songjie Wang Songjie Wang Xiao Chen Xiao Chen Weijian Huang Weijian Huang |
| author_facet | Lan Su Lan Su Xue Xia Xue Xia Dongjie Liang Dongjie Liang Shengjie Wu Shengjie Wu Lei Xu Lei Xu Tiancheng Xu Tiancheng Xu Songjie Wang Songjie Wang Xiao Chen Xiao Chen Weijian Huang Weijian Huang |
| author_sort | Lan Su |
| collection | DOAJ |
| description | Introduction: Antiarrhythmic drug therapy can affect pacemaker parameters in both the atrial and ventricular myocardium. It is not known whether antiarrhythmic drugs impact His bundle pacing/sensing parameters and His to ventricle (H-V) intervals following permanent His bundle pacing (HBP). The aims of the study were to prospectively determine the influence of rhythm and rate-controlling drugs on pacing parameters and H-V conduction after His bundle lead implantation and to assess the impact of rhythm and rate-controlling drugs on the safety of HBP.Materials and Methods: Patients (N = 140) with QRS duration < 120 ms who met permanent pacing indications were prospectively enrolled. Propafenone, lidocaine, and adenosine were injected intravenously after implantation of 3,830 lead during the procedure. Metoprolol succinate, amiodarone, and digoxin were taken orally for 1 month. Pacing parameters before and after drug intervention was measured, including His capture threshold, sensing and impedance, H-V interval, and conduction.Results: There were no statistically significant differences in His bundle pacing thresholds, impedance, and sensing after drug intervention at implantation or during a 2-month follow-up (P > 0.05). The HV interval was not affected except in the large-dose propafenone group where HV interval prolonged (P = 0.001). All patients maintained 1:1 H-V conduction following drug administration.Conclusion: There was no adverse impact on the HBP parameters or H-V conduction after the administration of commonly used dosage of rhythm and rate-controlling drugs. The drugs were safe in patients with permanent His bundle pacing. |
| first_indexed | 2024-12-14T17:44:09Z |
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| id | doaj.art-d08548d8b0c9401e969fb139de7d0e9f |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-14T17:44:09Z |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-d08548d8b0c9401e969fb139de7d0e9f2022-12-21T22:52:46ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2020-12-01710.3389/fcvm.2020.585165585165Effects of Rhythm and Rate-Controlling Drugs in Patients With Permanent His-Bundle PacingLan Su0Lan Su1Xue Xia2Xue Xia3Dongjie Liang4Dongjie Liang5Shengjie Wu6Shengjie Wu7Lei Xu8Lei Xu9Tiancheng Xu10Tiancheng Xu11Songjie Wang12Songjie Wang13Xiao Chen14Xiao Chen15Weijian Huang16Weijian Huang17Department of Cardiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaThe Key Lab of Cardiovascular Disease, Science and Technology of Wenzhou, Wenzhou, ChinaDepartment of Cardiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaThe Key Lab of Cardiovascular Disease, Science and Technology of Wenzhou, Wenzhou, ChinaDepartment of Cardiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaThe Key Lab of Cardiovascular Disease, Science and Technology of Wenzhou, Wenzhou, ChinaDepartment of Cardiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaThe Key Lab of Cardiovascular Disease, Science and Technology of Wenzhou, Wenzhou, ChinaDepartment of Cardiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaThe Key Lab of Cardiovascular Disease, Science and Technology of Wenzhou, Wenzhou, ChinaDepartment of Cardiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaThe Key Lab of Cardiovascular Disease, Science and Technology of Wenzhou, Wenzhou, ChinaDepartment of Cardiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaThe Key Lab of Cardiovascular Disease, Science and Technology of Wenzhou, Wenzhou, ChinaDepartment of Cardiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaThe Key Lab of Cardiovascular Disease, Science and Technology of Wenzhou, Wenzhou, ChinaDepartment of Cardiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaThe Key Lab of Cardiovascular Disease, Science and Technology of Wenzhou, Wenzhou, ChinaIntroduction: Antiarrhythmic drug therapy can affect pacemaker parameters in both the atrial and ventricular myocardium. It is not known whether antiarrhythmic drugs impact His bundle pacing/sensing parameters and His to ventricle (H-V) intervals following permanent His bundle pacing (HBP). The aims of the study were to prospectively determine the influence of rhythm and rate-controlling drugs on pacing parameters and H-V conduction after His bundle lead implantation and to assess the impact of rhythm and rate-controlling drugs on the safety of HBP.Materials and Methods: Patients (N = 140) with QRS duration < 120 ms who met permanent pacing indications were prospectively enrolled. Propafenone, lidocaine, and adenosine were injected intravenously after implantation of 3,830 lead during the procedure. Metoprolol succinate, amiodarone, and digoxin were taken orally for 1 month. Pacing parameters before and after drug intervention was measured, including His capture threshold, sensing and impedance, H-V interval, and conduction.Results: There were no statistically significant differences in His bundle pacing thresholds, impedance, and sensing after drug intervention at implantation or during a 2-month follow-up (P > 0.05). The HV interval was not affected except in the large-dose propafenone group where HV interval prolonged (P = 0.001). All patients maintained 1:1 H-V conduction following drug administration.Conclusion: There was no adverse impact on the HBP parameters or H-V conduction after the administration of commonly used dosage of rhythm and rate-controlling drugs. The drugs were safe in patients with permanent His bundle pacing.https://www.frontiersin.org/articles/10.3389/fcvm.2020.585165/fullhis bundle pacing (HBP)antiarrhythmic drugsH-V conductionsafetypacing parametersrhythm and rate-controlling |
| spellingShingle | Lan Su Lan Su Xue Xia Xue Xia Dongjie Liang Dongjie Liang Shengjie Wu Shengjie Wu Lei Xu Lei Xu Tiancheng Xu Tiancheng Xu Songjie Wang Songjie Wang Xiao Chen Xiao Chen Weijian Huang Weijian Huang Effects of Rhythm and Rate-Controlling Drugs in Patients With Permanent His-Bundle Pacing Frontiers in Cardiovascular Medicine his bundle pacing (HBP) antiarrhythmic drugs H-V conduction safety pacing parameters rhythm and rate-controlling |
| title | Effects of Rhythm and Rate-Controlling Drugs in Patients With Permanent His-Bundle Pacing |
| title_full | Effects of Rhythm and Rate-Controlling Drugs in Patients With Permanent His-Bundle Pacing |
| title_fullStr | Effects of Rhythm and Rate-Controlling Drugs in Patients With Permanent His-Bundle Pacing |
| title_full_unstemmed | Effects of Rhythm and Rate-Controlling Drugs in Patients With Permanent His-Bundle Pacing |
| title_short | Effects of Rhythm and Rate-Controlling Drugs in Patients With Permanent His-Bundle Pacing |
| title_sort | effects of rhythm and rate controlling drugs in patients with permanent his bundle pacing |
| topic | his bundle pacing (HBP) antiarrhythmic drugs H-V conduction safety pacing parameters rhythm and rate-controlling |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2020.585165/full |
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