Estudo químico de Sinningia allagophylla guiado por testes de atividade antiproliferativa

Estudo químico de Sinningia allagophylla guiado por testes de atividade antiproliferativa

Activity guided fractionation of Sinningia allagophylla (Mart.) Wiehler ethanolic extract yielded a new benzochromene 8-methoxylapachenol, besides seven known compounds: lapachenol, sitosteryl oleate, sitosteryl linoleate, stigmasteryl oleate, stigmasteryl linoleate, dunniol and tectoquinone. Extrac...

Full description

Bibliographic Details
Main Authors: Dilamara Riva, Andersson Barison, Maria Élida Alves Stefanello, Clarisse Bolfe Poliquesi, Ana Lúcia Tasca Goes Ruiz, João Ernesto de Carvalho, Marcos José Salvador
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2012-01-01
Series:Química Nova
Subjects:
Sinningia allagophylla
Gesneriaceae
antiproliferative activity
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000500020&lng=en&tlng=en
Description
Summary:Activity guided fractionation of Sinningia allagophylla (Mart.) Wiehler ethanolic extract yielded a new benzochromene 8-methoxylapachenol, besides seven known compounds: lapachenol, sitosteryl oleate, sitosteryl linoleate, stigmasteryl oleate, stigmasteryl linoleate, dunniol and tectoquinone. Extract, fractions, and compounds lapachenol, 8-methoxylapachenol, and dunniol were tested in vitro against human cancer cell lines U251 (glioma, CNS), MCF-7 (breast), NCI-ADR/RES (drug-resistant ovarian), 786-0 (kidney), NCI-H460 (lung, no small cells), PC-3 (prostate), OVCAR-3 (ovarian), HT-29 (colon), K562 (leukemia) and against VERO, a normal cell line. The most active compound was dunniol, which inhibited the growth of U251, MCF-7, NCI-ADR/RES, OVCAR-3 and K562 cell lines.
ISSN:1678-7064

Similar Items