Comprehensive Analysis of Chemotherapeutic Agents That Induce Infectious Neutropenia
Chemotherapy-induced neutropenia (CIN) has been associated with a risk of infections and chemotherapy dose reductions and delays. The chemotherapy regimen remains one of the primary determinants of the risk of neutropenia, with some regimens being more myelotoxic than others. Although a number of cl...
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MDPI AG
2021-07-01
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Online Access: | https://www.mdpi.com/1424-8247/14/7/681 |
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author | Mashiro Okunaka Daisuke Kano Reiko Matsui Toshikatsu Kawasaki Yoshihiro Uesawa |
author_facet | Mashiro Okunaka Daisuke Kano Reiko Matsui Toshikatsu Kawasaki Yoshihiro Uesawa |
author_sort | Mashiro Okunaka |
collection | DOAJ |
description | Chemotherapy-induced neutropenia (CIN) has been associated with a risk of infections and chemotherapy dose reductions and delays. The chemotherapy regimen remains one of the primary determinants of the risk of neutropenia, with some regimens being more myelotoxic than others. Although a number of clinical trials have currently highlighted the risk of CIN with each chemotherapy regimen, only a few ones have comprehensively examined the risk associated with all chemotherapeutic agents. Therefore, this study aimed to investigate the risk factors and characteristics of CIN caused by each neoplastic agent using data from the large voluntary reporting Food and Drug Administration Adverse Event Reporting System database. Initially, univariate analysis showed that an age ≥ 65 years, the female sex, and treatment with chemotherapeutic agents were factors that caused CIN. Then, cluster and component analyses showed that cytotoxic agents (i.e., alkylating agents, antimetabolic agents, antineoplastic antibiotics, platinating agents, and plant-derived alkaloids) were associated with infection following neutropenia. This comprehensive analysis comparing CIN risk suggests that elderly or underweight patients treated with cytotoxic drugs require particularly careful monitoring. |
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issn | 1424-8247 |
language | English |
last_indexed | 2024-03-10T09:29:02Z |
publishDate | 2021-07-01 |
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spelling | doaj.art-d08a6eb53d9b4fc29904014cdf9fbfb32023-11-22T04:40:06ZengMDPI AGPharmaceuticals1424-82472021-07-0114768110.3390/ph14070681Comprehensive Analysis of Chemotherapeutic Agents That Induce Infectious NeutropeniaMashiro Okunaka0Daisuke Kano1Reiko Matsui2Toshikatsu Kawasaki3Yoshihiro Uesawa4Department of Medical Molecular Informatics, Meiji Pharmaceutical University, Kiyose, Tokyo 204-8588, JapanDepartment of Pharmacy, National Cancer Center Hospital East, Kashiwa, Chiba 277-8577, JapanDepartment of Pharmacy, National Cancer Center Hospital East, Kashiwa, Chiba 277-8577, JapanDepartment of Pharmacy, National Cancer Center Hospital East, Kashiwa, Chiba 277-8577, JapanDepartment of Medical Molecular Informatics, Meiji Pharmaceutical University, Kiyose, Tokyo 204-8588, JapanChemotherapy-induced neutropenia (CIN) has been associated with a risk of infections and chemotherapy dose reductions and delays. The chemotherapy regimen remains one of the primary determinants of the risk of neutropenia, with some regimens being more myelotoxic than others. Although a number of clinical trials have currently highlighted the risk of CIN with each chemotherapy regimen, only a few ones have comprehensively examined the risk associated with all chemotherapeutic agents. Therefore, this study aimed to investigate the risk factors and characteristics of CIN caused by each neoplastic agent using data from the large voluntary reporting Food and Drug Administration Adverse Event Reporting System database. Initially, univariate analysis showed that an age ≥ 65 years, the female sex, and treatment with chemotherapeutic agents were factors that caused CIN. Then, cluster and component analyses showed that cytotoxic agents (i.e., alkylating agents, antimetabolic agents, antineoplastic antibiotics, platinating agents, and plant-derived alkaloids) were associated with infection following neutropenia. This comprehensive analysis comparing CIN risk suggests that elderly or underweight patients treated with cytotoxic drugs require particularly careful monitoring.https://www.mdpi.com/1424-8247/14/7/681chemotherapy-induced neutropeniachemotherapeutic agentcancer |
spellingShingle | Mashiro Okunaka Daisuke Kano Reiko Matsui Toshikatsu Kawasaki Yoshihiro Uesawa Comprehensive Analysis of Chemotherapeutic Agents That Induce Infectious Neutropenia Pharmaceuticals chemotherapy-induced neutropenia chemotherapeutic agent cancer |
title | Comprehensive Analysis of Chemotherapeutic Agents That Induce Infectious Neutropenia |
title_full | Comprehensive Analysis of Chemotherapeutic Agents That Induce Infectious Neutropenia |
title_fullStr | Comprehensive Analysis of Chemotherapeutic Agents That Induce Infectious Neutropenia |
title_full_unstemmed | Comprehensive Analysis of Chemotherapeutic Agents That Induce Infectious Neutropenia |
title_short | Comprehensive Analysis of Chemotherapeutic Agents That Induce Infectious Neutropenia |
title_sort | comprehensive analysis of chemotherapeutic agents that induce infectious neutropenia |
topic | chemotherapy-induced neutropenia chemotherapeutic agent cancer |
url | https://www.mdpi.com/1424-8247/14/7/681 |
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