Gene–gene interaction and association of Wnt/Β-catenin signalling pathway gene polymorphisms with ankylosing spondylitis susceptibility in the Chinese Han population
Objectives: To explore the genetic interaction between Wnt/β-catenin signalling pathway genes and ankylosing spondylitis (AS) in the Chinese population. Methods: Six single-nucleotide polymorphisms (SNPs) in DKK1, LRP5, LRP6, and SOST genes were genotyped in 673 AS patients and 687 healthy controls...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-11-01
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| Series: | Autoimmunity |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/08916934.2019.1681984 |
| _version_ | 1797684765551230976 |
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| author | Rui Liu Xu Zhang Guangming Jiang Yubo Ma Jiajia Yang Meng Wu Renfang Han Mengya Chen Yaping Yuan Xingxing Hu Meijuan Pan Shengqian Xu Jianhua Xu Zongwen Shuai Yanfeng Zou Guixia Pan Faming Pan |
| author_facet | Rui Liu Xu Zhang Guangming Jiang Yubo Ma Jiajia Yang Meng Wu Renfang Han Mengya Chen Yaping Yuan Xingxing Hu Meijuan Pan Shengqian Xu Jianhua Xu Zongwen Shuai Yanfeng Zou Guixia Pan Faming Pan |
| author_sort | Rui Liu |
| collection | DOAJ |
| description | Objectives: To explore the genetic interaction between Wnt/β-catenin signalling pathway genes and ankylosing spondylitis (AS) in the Chinese population. Methods: Six single-nucleotide polymorphisms (SNPs) in DKK1, LRP5, LRP6, and SOST genes were genotyped in 673 AS patients and 687 healthy controls by using SNPs can Technic. Single marker genetic association analysis was performed. Haplotypes were constructed after linkage disequilibrium analysis; additive, multiplicative, and higher-order interactions were analysed. Results: The DKK1 gene rs1569198 polymorphism was significantly associated with AS susceptibility in females (χ2 = 4.55, p = .03), but the association disappeared after Bonferroni correction. Moreover, a haplotype (T-G) in the DKK1 gene showed a protective role in AS susceptibility in females (p = .04). Significant additive interactions were observed between DKK1: rs1896368 and LRP5: rs3736228, relative excess risk due to interaction (RERI) = 0.40, 95% CI = 0.08 – 0.71; attributable proportion due to interaction (AP) = 51%, 95% CI = 0.07 – 0.94, DKK1: rs1569198 and LRP5: rs3736228 (RERI = 0.49, 95% CI = 0.12 – 0.86; AP = 49%, 95% CI = 0.17 – 0.82), LRP5: rs3736228 and SOST: rs4792909 (RERI = 0.33, 95% CI = 0.002 – 0.65; AP = 41%, 95% CI = 0.01 – 0.81) in the dominant model. Conclusions: Our research implies a potential gene–gene interaction, thus revealing the importance of the Wnt/β-catenin signalling pathway for understanding the genetic architecture of AS. |
| first_indexed | 2024-03-12T00:34:31Z |
| format | Article |
| id | doaj.art-d08a814e0b4d4ef7a0432d9e3d03c57e |
| institution | Directory Open Access Journal |
| issn | 0891-6934 1607-842X |
| language | English |
| last_indexed | 2024-03-12T00:34:31Z |
| publishDate | 2019-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Autoimmunity |
| spelling | doaj.art-d08a814e0b4d4ef7a0432d9e3d03c57e2023-09-15T10:01:08ZengTaylor & Francis GroupAutoimmunity0891-69341607-842X2019-11-01527-828128810.1080/08916934.2019.16819841681984Gene–gene interaction and association of Wnt/Β-catenin signalling pathway gene polymorphisms with ankylosing spondylitis susceptibility in the Chinese Han populationRui Liu0Xu Zhang1Guangming Jiang2Yubo Ma3Jiajia Yang4Meng Wu5Renfang Han6Mengya Chen7Yaping Yuan8Xingxing Hu9Meijuan Pan10Shengqian Xu11Jianhua Xu12Zongwen Shuai13Yanfeng Zou14Guixia Pan15Faming Pan16Anhui Medical UniversityAnhui Medical UniversityAnhui Medical UniversityAnhui Medical UniversityAnhui Medical UniversityAnhui Medical UniversityAnhui Medical UniversityAnhui Medical UniversityAnhui Medical UniversityAnhui Medical UniversityThe First Affiliated Hospital of Anhui Medical UniversityThe First Affiliated Hospital of Anhui Medical UniversityThe First Affiliated Hospital of Anhui Medical UniversityThe First Affiliated Hospital of Anhui Medical UniversityAnhui Medical UniversityAnhui Medical UniversityAnhui Medical UniversityObjectives: To explore the genetic interaction between Wnt/β-catenin signalling pathway genes and ankylosing spondylitis (AS) in the Chinese population. Methods: Six single-nucleotide polymorphisms (SNPs) in DKK1, LRP5, LRP6, and SOST genes were genotyped in 673 AS patients and 687 healthy controls by using SNPs can Technic. Single marker genetic association analysis was performed. Haplotypes were constructed after linkage disequilibrium analysis; additive, multiplicative, and higher-order interactions were analysed. Results: The DKK1 gene rs1569198 polymorphism was significantly associated with AS susceptibility in females (χ2 = 4.55, p = .03), but the association disappeared after Bonferroni correction. Moreover, a haplotype (T-G) in the DKK1 gene showed a protective role in AS susceptibility in females (p = .04). Significant additive interactions were observed between DKK1: rs1896368 and LRP5: rs3736228, relative excess risk due to interaction (RERI) = 0.40, 95% CI = 0.08 – 0.71; attributable proportion due to interaction (AP) = 51%, 95% CI = 0.07 – 0.94, DKK1: rs1569198 and LRP5: rs3736228 (RERI = 0.49, 95% CI = 0.12 – 0.86; AP = 49%, 95% CI = 0.17 – 0.82), LRP5: rs3736228 and SOST: rs4792909 (RERI = 0.33, 95% CI = 0.002 – 0.65; AP = 41%, 95% CI = 0.01 – 0.81) in the dominant model. Conclusions: Our research implies a potential gene–gene interaction, thus revealing the importance of the Wnt/β-catenin signalling pathway for understanding the genetic architecture of AS.http://dx.doi.org/10.1080/08916934.2019.1681984ankylosing spondylitispolymorphisminteractiongenewnt/β-catenin |
| spellingShingle | Rui Liu Xu Zhang Guangming Jiang Yubo Ma Jiajia Yang Meng Wu Renfang Han Mengya Chen Yaping Yuan Xingxing Hu Meijuan Pan Shengqian Xu Jianhua Xu Zongwen Shuai Yanfeng Zou Guixia Pan Faming Pan Gene–gene interaction and association of Wnt/Β-catenin signalling pathway gene polymorphisms with ankylosing spondylitis susceptibility in the Chinese Han population Autoimmunity ankylosing spondylitis polymorphism interaction gene wnt/β-catenin |
| title | Gene–gene interaction and association of Wnt/Β-catenin signalling pathway gene polymorphisms with ankylosing spondylitis susceptibility in the Chinese Han population |
| title_full | Gene–gene interaction and association of Wnt/Β-catenin signalling pathway gene polymorphisms with ankylosing spondylitis susceptibility in the Chinese Han population |
| title_fullStr | Gene–gene interaction and association of Wnt/Β-catenin signalling pathway gene polymorphisms with ankylosing spondylitis susceptibility in the Chinese Han population |
| title_full_unstemmed | Gene–gene interaction and association of Wnt/Β-catenin signalling pathway gene polymorphisms with ankylosing spondylitis susceptibility in the Chinese Han population |
| title_short | Gene–gene interaction and association of Wnt/Β-catenin signalling pathway gene polymorphisms with ankylosing spondylitis susceptibility in the Chinese Han population |
| title_sort | gene gene interaction and association of wnt beta catenin signalling pathway gene polymorphisms with ankylosing spondylitis susceptibility in the chinese han population |
| topic | ankylosing spondylitis polymorphism interaction gene wnt/β-catenin |
| url | http://dx.doi.org/10.1080/08916934.2019.1681984 |
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