The gut microbiota in breast cancer development and treatment: The good, the bad, and the useful!
ABSTRACTRegardless of the global progress in early diagnosis and novel therapeutic regimens, breast carcinoma poses a devastating threat, and the advances are somewhat marred by high mortality rates. Breast cancer risk prediction models based on the known risk factors are extremely useful, but a lar...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
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| Series: | Gut Microbes |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2023.2221452 |
| _version_ | 1797236680938225664 |
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| author | Deeptashree Nandi Sheetal Parida Dipali Sharma |
| author_facet | Deeptashree Nandi Sheetal Parida Dipali Sharma |
| author_sort | Deeptashree Nandi |
| collection | DOAJ |
| description | ABSTRACTRegardless of the global progress in early diagnosis and novel therapeutic regimens, breast carcinoma poses a devastating threat, and the advances are somewhat marred by high mortality rates. Breast cancer risk prediction models based on the known risk factors are extremely useful, but a large number of breast cancers develop in women with no/low known risk. The gut microbiome exerts a profound impact on the host health and physiology and has emerged as a pivotal frontier in breast cancer pathogenesis. Progress in metagenomic analysis has enabled the identification of specific changes in the host microbial signature. In this review, we discuss the microbial and metabolomic changes associated with breast cancer initiation and metastatic progression. We summarize the bidirectional impact of various breast cancer-related therapies on gut microbiota and vice-versa. Finally, we discuss the strategies to modulate the gut microbiota toward a more favorable state that confers anticancer effects. |
| first_indexed | 2024-03-11T14:19:40Z |
| format | Article |
| id | doaj.art-d08ad7a8bb87467b8adf7680c7b0d23d |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-04-24T17:07:43Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-d08ad7a8bb87467b8adf7680c7b0d23d2024-03-28T22:38:20ZengTaylor & Francis GroupGut Microbes1949-09761949-09842023-12-0115110.1080/19490976.2023.2221452The gut microbiota in breast cancer development and treatment: The good, the bad, and the useful!Deeptashree Nandi0Sheetal Parida1Dipali Sharma2Dept. of Oncology, Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USADept. of Oncology, Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USADept. of Oncology, Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USAABSTRACTRegardless of the global progress in early diagnosis and novel therapeutic regimens, breast carcinoma poses a devastating threat, and the advances are somewhat marred by high mortality rates. Breast cancer risk prediction models based on the known risk factors are extremely useful, but a large number of breast cancers develop in women with no/low known risk. The gut microbiome exerts a profound impact on the host health and physiology and has emerged as a pivotal frontier in breast cancer pathogenesis. Progress in metagenomic analysis has enabled the identification of specific changes in the host microbial signature. In this review, we discuss the microbial and metabolomic changes associated with breast cancer initiation and metastatic progression. We summarize the bidirectional impact of various breast cancer-related therapies on gut microbiota and vice-versa. Finally, we discuss the strategies to modulate the gut microbiota toward a more favorable state that confers anticancer effects.https://www.tandfonline.com/doi/10.1080/19490976.2023.2221452Microbiomegut microbiotabreast cancerdysbiosisanticancertherapy |
| spellingShingle | Deeptashree Nandi Sheetal Parida Dipali Sharma The gut microbiota in breast cancer development and treatment: The good, the bad, and the useful! Gut Microbes Microbiome gut microbiota breast cancer dysbiosis anticancer therapy |
| title | The gut microbiota in breast cancer development and treatment: The good, the bad, and the useful! |
| title_full | The gut microbiota in breast cancer development and treatment: The good, the bad, and the useful! |
| title_fullStr | The gut microbiota in breast cancer development and treatment: The good, the bad, and the useful! |
| title_full_unstemmed | The gut microbiota in breast cancer development and treatment: The good, the bad, and the useful! |
| title_short | The gut microbiota in breast cancer development and treatment: The good, the bad, and the useful! |
| title_sort | gut microbiota in breast cancer development and treatment the good the bad and the useful |
| topic | Microbiome gut microbiota breast cancer dysbiosis anticancer therapy |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2023.2221452 |
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