Elevation of BSF-2 Level in Serum of Patients with Hepatitis B Virus
Background: Hepatitis B is the main infection of the injured liver for humans. Inflammation of the liver is caused by hepatitis viruses may lead to cirrhosis and hepatocellular carcinoma. The B-cell stimulatory factor 2 (BSF-2) is one of the cytokines that affect the regulation and differentiation o...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2021-03-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/2091 |
| _version_ | 1797197910983573504 |
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| author | Ali A. Dawood Mahmood A. A. Altobje Zeyad T. Alrassam |
| author_facet | Ali A. Dawood Mahmood A. A. Altobje Zeyad T. Alrassam |
| author_sort | Ali A. Dawood |
| collection | DOAJ |
| description | Background: Hepatitis B is the main infection of the injured liver for humans. Inflammation of the liver is caused by hepatitis viruses may lead to cirrhosis and hepatocellular carcinoma. The B-cell stimulatory factor 2 (BSF-2) is one of the cytokines that affect the regulation and differentiation of the human immune response. Objective: this report aims to estimate the BSF-2, GPT, and GOT levels in patients’ serum with different stages of hepatitis B compared with healthy control. Methods: This study assessed 52 patients presumably with acute and chronic cases who have HBsAg positive. BSF-2 was detected using ELISA assay. Biochemical parameters were determined using kits of an automated analyzer. SPSS version-16 software was used for statistical analysis. Results: Acute hepatitis B patients had shown elevation in BSF-2 level more than of chronic hepatitis B. GPT and GOT levels elevated in the acute hepatitis group more than of the chronic hepatitis group. We reported a significant value between BSF-2, GOT, and GPT levels. We didn’t score an association between patient’s age and cases groups of hepatitis. Conclusion: our data confirmed increasing of BSF-2 levels with the increase of GOT level more than GPT level with acute hepatitis B. BSF-2, GPT and GOT levels are varied in different courses of acute and chronic HBV. We surmised that the elevation of BSF-2 levels designates liver injury of patients with acute HBV. |
| first_indexed | 2024-03-08T05:48:08Z |
| format | Article |
| id | doaj.art-d08b5f1330c6481a8eed548316af0320 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:51:29Z |
| publishDate | 2021-03-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-d08b5f1330c6481a8eed548316af03202024-04-22T13:07:46ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2021-03-01231879410.15789/1563-0625-EOB-20911362Elevation of BSF-2 Level in Serum of Patients with Hepatitis B VirusAli A. Dawood0Mahmood A. A. Altobje1Zeyad T. Alrassam2College of Medicine, University of MosulCollege of Medicine, University of MosulCollege of Medicine, University of MosulBackground: Hepatitis B is the main infection of the injured liver for humans. Inflammation of the liver is caused by hepatitis viruses may lead to cirrhosis and hepatocellular carcinoma. The B-cell stimulatory factor 2 (BSF-2) is one of the cytokines that affect the regulation and differentiation of the human immune response. Objective: this report aims to estimate the BSF-2, GPT, and GOT levels in patients’ serum with different stages of hepatitis B compared with healthy control. Methods: This study assessed 52 patients presumably with acute and chronic cases who have HBsAg positive. BSF-2 was detected using ELISA assay. Biochemical parameters were determined using kits of an automated analyzer. SPSS version-16 software was used for statistical analysis. Results: Acute hepatitis B patients had shown elevation in BSF-2 level more than of chronic hepatitis B. GPT and GOT levels elevated in the acute hepatitis group more than of the chronic hepatitis group. We reported a significant value between BSF-2, GOT, and GPT levels. We didn’t score an association between patient’s age and cases groups of hepatitis. Conclusion: our data confirmed increasing of BSF-2 levels with the increase of GOT level more than GPT level with acute hepatitis B. BSF-2, GPT and GOT levels are varied in different courses of acute and chronic HBV. We surmised that the elevation of BSF-2 levels designates liver injury of patients with acute HBV.https://www.mimmun.ru/mimmun/article/view/2091elisagptgotbsf-2hbsag |
| spellingShingle | Ali A. Dawood Mahmood A. A. Altobje Zeyad T. Alrassam Elevation of BSF-2 Level in Serum of Patients with Hepatitis B Virus Медицинская иммунология elisa gpt got bsf-2 hbsag |
| title | Elevation of BSF-2 Level in Serum of Patients with Hepatitis B Virus |
| title_full | Elevation of BSF-2 Level in Serum of Patients with Hepatitis B Virus |
| title_fullStr | Elevation of BSF-2 Level in Serum of Patients with Hepatitis B Virus |
| title_full_unstemmed | Elevation of BSF-2 Level in Serum of Patients with Hepatitis B Virus |
| title_short | Elevation of BSF-2 Level in Serum of Patients with Hepatitis B Virus |
| title_sort | elevation of bsf 2 level in serum of patients with hepatitis b virus |
| topic | elisa gpt got bsf-2 hbsag |
| url | https://www.mimmun.ru/mimmun/article/view/2091 |
| work_keys_str_mv | AT aliadawood elevationofbsf2levelinserumofpatientswithhepatitisbvirus AT mahmoodaaaltobje elevationofbsf2levelinserumofpatientswithhepatitisbvirus AT zeyadtalrassam elevationofbsf2levelinserumofpatientswithhepatitisbvirus |