Quantification of Anterior Chamber Particles Using Anterior Segment Optical Coherence Tomography in Angle-Closure Glaucoma Patients after Laser Iridotomy
Purpose: To determine whether the degree of particle density in the anterior chamber can be evaluated objectively and quantitatively by anterior segment optical coherence tomography (AS-OCT) in cases after laser iridotomy (LI). Methods: This was a retrospective observational study. All of the subjec...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/15/4379 |
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| author | Naoya Yoshihara Hiroto Terasaki Hideki Shiihara Ryoh Funatsu Takehiro Yamashita Taiji Sakamoto |
| author_facet | Naoya Yoshihara Hiroto Terasaki Hideki Shiihara Ryoh Funatsu Takehiro Yamashita Taiji Sakamoto |
| author_sort | Naoya Yoshihara |
| collection | DOAJ |
| description | Purpose: To determine whether the degree of particle density in the anterior chamber can be evaluated objectively and quantitatively by anterior segment optical coherence tomography (AS-OCT) in cases after laser iridotomy (LI). Methods: This was a retrospective observational study. All of the subjects who received LI for angle-closure glaucoma between January 2018 and May 2019 at Kagoshima University Hospital were studied. AS-OCT recordings were made before, immediately after, and one week after LI in 22 eyes of 14 consecutive patients. The anterior chamber particle (ACP) index was defined as the ratio of the number of particles in the anterior chamber to the total area of the anterior chamber. The ACP index was determined by binarization of the AS-OCT images and analysis with the ImageJ program. Results: The mean age of the participants was 75.4 ± 8.9 years, with a range of 61–91 years. The ACP index before the LI was 0.78 ± 0.68, and it was significantly increased to 7.72 ± 2.64 immediately after the LI (paired <i>t</i>-test, <i>p</i> < 0.01). The ACP index returned to the pre-LI density of 0.92 ± 0.48 one week after the LI. Conclusions: We successfully quantified the degree of anterior chamber particles accumulation by analyzing images obtained by AS-OCT. This simple and repeatable technique should be useful because the particles, including inflammatory cells, in the anterior chamber can be evaluated non-invasively and objectively. |
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| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T12:28:07Z |
| publishDate | 2022-07-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-d08bb069b3e7427e9e3e12ab8ee9d0712023-11-30T22:32:44ZengMDPI AGJournal of Clinical Medicine2077-03832022-07-011115437910.3390/jcm11154379Quantification of Anterior Chamber Particles Using Anterior Segment Optical Coherence Tomography in Angle-Closure Glaucoma Patients after Laser IridotomyNaoya Yoshihara0Hiroto Terasaki1Hideki Shiihara2Ryoh Funatsu3Takehiro Yamashita4Taiji Sakamoto5Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, JapanDepartment of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, JapanDepartment of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, JapanDepartment of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, JapanDepartment of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, JapanDepartment of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, JapanPurpose: To determine whether the degree of particle density in the anterior chamber can be evaluated objectively and quantitatively by anterior segment optical coherence tomography (AS-OCT) in cases after laser iridotomy (LI). Methods: This was a retrospective observational study. All of the subjects who received LI for angle-closure glaucoma between January 2018 and May 2019 at Kagoshima University Hospital were studied. AS-OCT recordings were made before, immediately after, and one week after LI in 22 eyes of 14 consecutive patients. The anterior chamber particle (ACP) index was defined as the ratio of the number of particles in the anterior chamber to the total area of the anterior chamber. The ACP index was determined by binarization of the AS-OCT images and analysis with the ImageJ program. Results: The mean age of the participants was 75.4 ± 8.9 years, with a range of 61–91 years. The ACP index before the LI was 0.78 ± 0.68, and it was significantly increased to 7.72 ± 2.64 immediately after the LI (paired <i>t</i>-test, <i>p</i> < 0.01). The ACP index returned to the pre-LI density of 0.92 ± 0.48 one week after the LI. Conclusions: We successfully quantified the degree of anterior chamber particles accumulation by analyzing images obtained by AS-OCT. This simple and repeatable technique should be useful because the particles, including inflammatory cells, in the anterior chamber can be evaluated non-invasively and objectively.https://www.mdpi.com/2077-0383/11/15/4379anterior segment optical coherence tomographyanterior chamberobjective quantificationlaser iridotomy |
| spellingShingle | Naoya Yoshihara Hiroto Terasaki Hideki Shiihara Ryoh Funatsu Takehiro Yamashita Taiji Sakamoto Quantification of Anterior Chamber Particles Using Anterior Segment Optical Coherence Tomography in Angle-Closure Glaucoma Patients after Laser Iridotomy Journal of Clinical Medicine anterior segment optical coherence tomography anterior chamber objective quantification laser iridotomy |
| title | Quantification of Anterior Chamber Particles Using Anterior Segment Optical Coherence Tomography in Angle-Closure Glaucoma Patients after Laser Iridotomy |
| title_full | Quantification of Anterior Chamber Particles Using Anterior Segment Optical Coherence Tomography in Angle-Closure Glaucoma Patients after Laser Iridotomy |
| title_fullStr | Quantification of Anterior Chamber Particles Using Anterior Segment Optical Coherence Tomography in Angle-Closure Glaucoma Patients after Laser Iridotomy |
| title_full_unstemmed | Quantification of Anterior Chamber Particles Using Anterior Segment Optical Coherence Tomography in Angle-Closure Glaucoma Patients after Laser Iridotomy |
| title_short | Quantification of Anterior Chamber Particles Using Anterior Segment Optical Coherence Tomography in Angle-Closure Glaucoma Patients after Laser Iridotomy |
| title_sort | quantification of anterior chamber particles using anterior segment optical coherence tomography in angle closure glaucoma patients after laser iridotomy |
| topic | anterior segment optical coherence tomography anterior chamber objective quantification laser iridotomy |
| url | https://www.mdpi.com/2077-0383/11/15/4379 |
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