Pattern of Non Motor Symptoms in Parkinson’s Disease: A Prospective Observational Study from a Tertiary Care Centre, Bihar, India
Introduction: Non motor symptoms are highly prevalent in Parkinson’s Disease (PD) but are often overshadowed by the dominance of motor symptoms. Aim: To assess non motor symptoms in patients with Parkinson’s disease. Materials and Methods: In this prospective observational study, patients of PD fu...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2022-09-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/16845/56861_CE(OM)_F[SK]_PF1(SC_OM)_PFA(SC_KM)_PN(KM).pdf |
| _version_ | 1797900453681299456 |
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| author | Anand Kumar Rai Abhay Ranjan Sanaullah Mudassir Ashok Kumar |
| author_facet | Anand Kumar Rai Abhay Ranjan Sanaullah Mudassir Ashok Kumar |
| author_sort | Anand Kumar Rai |
| collection | DOAJ |
| description | Introduction: Non motor symptoms are highly prevalent in Parkinson’s Disease (PD) but are often overshadowed by the dominance of motor symptoms.
Aim: To assess non motor symptoms in patients with Parkinson’s disease.
Materials and Methods: In this prospective observational study, patients of PD fulfilling United Kingdom Parkinson’s Disease Society Brain Bank (UKPDSBB) criteria were recruited, between August 2019 to July 2021, in the Neurology Department of Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India. The pattern of Non Motor Symptoms (NMS) in PD was studied using detailed questionnaire and association of NMS with age, gender and modified Hoehn and Yahr stage were assessed. Chi-square test and Student’s t-test was calculated where required.
Results: Total 102 patients were included, with male constituting 73.5% patients. The mean age was 60.14±13.55 years. Constipation 74 (72.55%) was the most common NMS. Most of the patients belonged to mild stage (52.94%) followed by moderate (40.20%) and severe (6.86%) stages, according to modified Hoehn and Yahr classification. Rapid Eye Movement (REM) sleep behaviour disorder (n=15) and sexual dysfunction (n=28) were significantly more prevalent in male patients. Depression, REM sleep behaviour disorder, olfactory disturbance, visual disturbance, urinary urgency, sweating abnormality, constipation, vomiting and visual blurring were significantly common in patients with earlier disease stages while psychosis in patients with advanced stage.
Conclusion: This study showed the high prevalence of NMS in PD patient which is consistent with other studies, but there are differences in the frequency of individual symptoms which may relate to cultural and geographic differences. |
| first_indexed | 2024-04-10T08:46:15Z |
| format | Article |
| id | doaj.art-d08ea6a3fab94a18902e10722add685f |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-10T08:46:15Z |
| publishDate | 2022-09-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-d08ea6a3fab94a18902e10722add685f2023-02-22T08:38:56ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2022-09-01169OM01OM0410.7860/JCDR/2022/56861.16845Pattern of Non Motor Symptoms in Parkinson’s Disease: A Prospective Observational Study from a Tertiary Care Centre, Bihar, IndiaAnand Kumar Rai 0Abhay Ranjan1Sanaullah Mudassir2Ashok Kumar3Assistant Professor, Department of Neurology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.Associate Professor, Department of Neurology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.Senior Resident, Department of Neurology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.Professor, Department of Neurology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.Introduction: Non motor symptoms are highly prevalent in Parkinson’s Disease (PD) but are often overshadowed by the dominance of motor symptoms. Aim: To assess non motor symptoms in patients with Parkinson’s disease. Materials and Methods: In this prospective observational study, patients of PD fulfilling United Kingdom Parkinson’s Disease Society Brain Bank (UKPDSBB) criteria were recruited, between August 2019 to July 2021, in the Neurology Department of Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India. The pattern of Non Motor Symptoms (NMS) in PD was studied using detailed questionnaire and association of NMS with age, gender and modified Hoehn and Yahr stage were assessed. Chi-square test and Student’s t-test was calculated where required. Results: Total 102 patients were included, with male constituting 73.5% patients. The mean age was 60.14±13.55 years. Constipation 74 (72.55%) was the most common NMS. Most of the patients belonged to mild stage (52.94%) followed by moderate (40.20%) and severe (6.86%) stages, according to modified Hoehn and Yahr classification. Rapid Eye Movement (REM) sleep behaviour disorder (n=15) and sexual dysfunction (n=28) were significantly more prevalent in male patients. Depression, REM sleep behaviour disorder, olfactory disturbance, visual disturbance, urinary urgency, sweating abnormality, constipation, vomiting and visual blurring were significantly common in patients with earlier disease stages while psychosis in patients with advanced stage. Conclusion: This study showed the high prevalence of NMS in PD patient which is consistent with other studies, but there are differences in the frequency of individual symptoms which may relate to cultural and geographic differences.https://jcdr.net/articles/PDF/16845/56861_CE(OM)_F[SK]_PF1(SC_OM)_PFA(SC_KM)_PN(KM).pdfconstipationdepressionmodified hoehn and yahr stagingsleep behaviour disorderurinary urgency |
| spellingShingle | Anand Kumar Rai Abhay Ranjan Sanaullah Mudassir Ashok Kumar Pattern of Non Motor Symptoms in Parkinson’s Disease: A Prospective Observational Study from a Tertiary Care Centre, Bihar, India Journal of Clinical and Diagnostic Research constipation depression modified hoehn and yahr staging sleep behaviour disorder urinary urgency |
| title | Pattern of Non Motor Symptoms in Parkinson’s Disease: A Prospective Observational Study from a Tertiary Care Centre, Bihar, India |
| title_full | Pattern of Non Motor Symptoms in Parkinson’s Disease: A Prospective Observational Study from a Tertiary Care Centre, Bihar, India |
| title_fullStr | Pattern of Non Motor Symptoms in Parkinson’s Disease: A Prospective Observational Study from a Tertiary Care Centre, Bihar, India |
| title_full_unstemmed | Pattern of Non Motor Symptoms in Parkinson’s Disease: A Prospective Observational Study from a Tertiary Care Centre, Bihar, India |
| title_short | Pattern of Non Motor Symptoms in Parkinson’s Disease: A Prospective Observational Study from a Tertiary Care Centre, Bihar, India |
| title_sort | pattern of non motor symptoms in parkinson s disease a prospective observational study from a tertiary care centre bihar india |
| topic | constipation depression modified hoehn and yahr staging sleep behaviour disorder urinary urgency |
| url | https://jcdr.net/articles/PDF/16845/56861_CE(OM)_F[SK]_PF1(SC_OM)_PFA(SC_KM)_PN(KM).pdf |
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